Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C16H15Cl2N |
| Molecular Weight | 292.203 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@H]1CC[C@@H](C2=CC(Cl)=C(Cl)C=C2)C3=C1C=CC=C3
InChI
InChIKey=SRPXSILJHWNFMK-ZBEGNZNMSA-N
InChI=1S/C16H15Cl2N/c17-14-7-5-10(9-15(14)18)11-6-8-16(19)13-4-2-1-3-12(11)13/h1-5,7,9,11,16H,6,8,19H2/t11-,16-/m0/s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacokinetics of sertraline in relation to genetic polymorphism of CYP2C19. | 2001 Jul |
|
| Platelet inhibition by sertraline and N-desmethylsertraline: a possible missing link between depression, coronary events, and mortality benefits of selective serotonin reuptake inhibitors. | 2001 May |
|
| The selective serotonin reuptake inhibitor sertraline: its profile and use in psychiatric disorders. | 2001 Spring |
|
| Inhibition of P-glycoprotein by newer antidepressants. | 2003 Apr |
|
| The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations. | 2003 Jan |
|
| Effects of an educational compliance enhancement programme and therapeutic drug monitoring on treatment adherence in depressed patients managed by general practitioners. | 2003 Nov |
|
| A novel system for the determination of antidepressant concentrations in human breast milk. | 2004 Feb |
|
| Serum disposition of sertraline, N-desmethylsertraline and paroxetine: a pharmacokinetic evaluation of repeated drug concentration measurements during 6 months of treatment for major depression. | 2004 Jul |
|
| A pilot study of newer antidepressant concentrations in cord and maternal serum and possible effects in the neonate. | 2004 Sep |
|
| Development of a solid phase extraction for 13 'new' generation antidepressants and their active metabolites for gas chromatographic-mass spectrometric analysis. | 2005 Dec 9 |
|
| Determination of select antidepressants in fish from an effluent-dominated stream. | 2005 Feb |
|
| Relationship between release of platelet/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression. | 2005 Jun |
|
| Comparison of electron and chemical ionization modes by validation of a quantitative gas chromatographic-mass spectrometric assay of new generation antidepressants and their active metabolites in plasma. | 2007 Dec 28 |
|
| Addition of risperidone to sertraline improves sertraline-resistant refractory depression without influencing plasma concentrations of sertraline and desmethylsertraline. | 2008 Dec |
|
| Serum concentrations of sertraline and N-desmethyl sertraline in relation to CYP2C19 genotype in psychiatric patients. | 2008 Dec |
|
| Identification of primary care patients at risk of nonadherence to antidepressant treatment. | 2008 Feb 2 |
|
| Analysis of second-generation antidepressant drug, sertraline and its active metabolite, N-desmethyl sertraline in human plasma by a sensitive and selective liquid chromatography-tandem mass spectrometry method. | 2009 Jan 15 |
|
| Determination of antidepressants in human postmortem blood, brain tissue, and hair using gas chromatography-mass spectrometry. | 2009 Nov |
|
| Partial compliance as determined from plasma levels of sertraline and its metabolite in depressed patients in primary care. | 2010 Dec |
Patents
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Systematic Name | English | ||
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Code | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
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114743
Created by
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CJJ71O9BE8
Created by
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SUB112492
Created by
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DB14071
Created by
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Desmethylsertraline
Created by
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87857-41-8
Created by
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DTXSID60236666
Created by
admin on Sat Dec 16 08:34:23 GMT 2023 , Edited by admin on Sat Dec 16 08:34:23 GMT 2023
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100000142067
Created by
admin on Sat Dec 16 08:34:23 GMT 2023 , Edited by admin on Sat Dec 16 08:34:23 GMT 2023
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PRIMARY |
PARENT (METABOLITE LESS ACTIVE)
SUBSTANCE RECORD
