Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C23H19Cl2N3O4 |
Molecular Weight | 472.321 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@@H](CC1=CC(Cl)=C(OCC2=C3OC(=NC3=CC(N)=C2)C4=CC=CC=C4)C(Cl)=C1)C(O)=O
InChI
InChIKey=XNRZJPQTMQZBCE-SFHVURJKSA-N
InChI=1S/C23H19Cl2N3O4/c24-16-6-12(8-18(27)23(29)30)7-17(25)21(16)31-11-14-9-15(26)10-19-20(14)32-22(28-19)13-4-2-1-3-5-13/h1-7,9-10,18H,8,11,26-27H2,(H,29,30)/t18-/m0/s1
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: Q01650 Gene ID: 8140.0 Gene Symbol: SLC7A5 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/24492461 |
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Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
872522
Created by
admin on Sat Dec 16 12:02:10 GMT 2023 , Edited by admin on Sat Dec 16 12:02:10 GMT 2023
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Code System | Code | Type | Description | ||
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JPH-203
Created by
admin on Sat Dec 16 12:02:10 GMT 2023 , Edited by admin on Sat Dec 16 12:02:10 GMT 2023
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PRIMARY | MedKoo CAT#: 406760; CAS#: 1037592-40-7;Description: JPH203, also known as KYT-0353, is a potent and selective LAT1 selective ( L-type amino acid transporter 1) inhibitor. JPH203 can very potently inhibit l-leucine uptake. JPH203 inhibits YD-38 cell growth. JPH203 up-regulated the population of apoptotic YD-38 cells through the activation of apoptotic factors, including caspases and PARP. (last updated: 7/13/2016). | ||
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300000032239
Created by
admin on Sat Dec 16 12:02:10 GMT 2023 , Edited by admin on Sat Dec 16 12:02:10 GMT 2023
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24853505
Created by
admin on Sat Dec 16 12:02:10 GMT 2023 , Edited by admin on Sat Dec 16 12:02:10 GMT 2023
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C179105
Created by
admin on Sat Dec 16 12:02:10 GMT 2023 , Edited by admin on Sat Dec 16 12:02:10 GMT 2023
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CEDO9QXYZK
Created by
admin on Sat Dec 16 12:02:10 GMT 2023 , Edited by admin on Sat Dec 16 12:02:10 GMT 2023
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1037592-40-7
Created by
admin on Sat Dec 16 12:02:10 GMT 2023 , Edited by admin on Sat Dec 16 12:02:10 GMT 2023
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11602
Created by
admin on Sat Dec 16 12:02:10 GMT 2023 , Edited by admin on Sat Dec 16 12:02:10 GMT 2023
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PRIMARY | INN |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)