U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C23H19Cl2N3O4
Molecular Weight 472.321
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NANVURANLAT

SMILES

N[C@@H](CC1=CC(Cl)=C(OCC2=C3OC(=NC3=CC(N)=C2)C4=CC=CC=C4)C(Cl)=C1)C(O)=O

InChI

InChIKey=XNRZJPQTMQZBCE-SFHVURJKSA-N
InChI=1S/C23H19Cl2N3O4/c24-16-6-12(8-18(27)23(29)30)7-17(25)21(16)31-11-14-9-15(26)10-19-20(14)32-22(28-19)13-4-2-1-3-5-13/h1-7,9-10,18H,8,11,26-27H2,(H,29,30)/t18-/m0/s1

HIDE SMILES / InChI

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Q01650
Gene ID: 8140.0
Gene Symbol: SLC7A5
Target Organism: Homo sapiens (Human)
Name Type Language
NANVURANLAT
INN  
Official Name English
KYT-0353
Code English
JPH 203
Code English
L-TYROSINE, O-((5-AMINO-2-PHENYL-7-BENZOXAZOLYL)METHYL)-3,5-DICHLORO-
Systematic Name English
nanvuranlat [INN]
Common Name English
(2S)-2-AMINO-3-(4-((5-AMINO-2-PHENYL-1,3-BENZOXAZOL-7-YL)METHOXY)-3,5-DICHLORO-PHENYL)PROPANOIC ACID
Systematic Name English
O-((5-AMINO-2-PHENYL-1,3-BENZOXAZOL-7-YL)METHYL)-3,5- DICHLORO-L-TYROSINE
Systematic Name English
JPH-203
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 872522
Created by admin on Sat Dec 16 12:02:10 GMT 2023 , Edited by admin on Sat Dec 16 12:02:10 GMT 2023
Code System Code Type Description
MANUFACTURER PRODUCT INFORMATION
JPH-203
Created by admin on Sat Dec 16 12:02:10 GMT 2023 , Edited by admin on Sat Dec 16 12:02:10 GMT 2023
PRIMARY MedKoo CAT#: 406760; CAS#: 1037592-40-7;Description: JPH203, also known as KYT-0353, is a potent and selective LAT1 selective ( L-type amino acid transporter 1) inhibitor. JPH203 can very potently inhibit l-leucine uptake. JPH203 inhibits YD-38 cell growth. JPH203 up-regulated the population of apoptotic YD-38 cells through the activation of apoptotic factors, including caspases and PARP. (last updated: 7/13/2016).
SMS_ID
300000032239
Created by admin on Sat Dec 16 12:02:10 GMT 2023 , Edited by admin on Sat Dec 16 12:02:10 GMT 2023
PRIMARY
PUBCHEM
24853505
Created by admin on Sat Dec 16 12:02:10 GMT 2023 , Edited by admin on Sat Dec 16 12:02:10 GMT 2023
PRIMARY
NCI_THESAURUS
C179105
Created by admin on Sat Dec 16 12:02:10 GMT 2023 , Edited by admin on Sat Dec 16 12:02:10 GMT 2023
PRIMARY
FDA UNII
CEDO9QXYZK
Created by admin on Sat Dec 16 12:02:10 GMT 2023 , Edited by admin on Sat Dec 16 12:02:10 GMT 2023
PRIMARY
CAS
1037592-40-7
Created by admin on Sat Dec 16 12:02:10 GMT 2023 , Edited by admin on Sat Dec 16 12:02:10 GMT 2023
PRIMARY
INN
11602
Created by admin on Sat Dec 16 12:02:10 GMT 2023 , Edited by admin on Sat Dec 16 12:02:10 GMT 2023
PRIMARY INN