Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C23H19Cl2N3O4 |
| Molecular Weight | 472.321 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@@H](CC1=CC(Cl)=C(OCC2=CC(N)=CC3=C2OC(=N3)C4=CC=CC=C4)C(Cl)=C1)C(O)=O
InChI
InChIKey=XNRZJPQTMQZBCE-SFHVURJKSA-N
InChI=1S/C23H19Cl2N3O4/c24-16-6-12(8-18(27)23(29)30)7-17(25)21(16)31-11-14-9-15(26)10-19-20(14)32-22(28-19)13-4-2-1-3-5-13/h1-7,9-10,18H,8,11,26-27H2,(H,29,30)/t18-/m0/s1
Approval Year
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
463.1 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32198649/ |
12 mg/m² single, intravenous dose: 12 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered: |
JPH-203 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
887.8 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32198649/ |
25 mg/m² single, intravenous dose: 25 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered: |
JPH-203 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
1460.5 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32198649/ |
40 mg/m² single, intravenous dose: 40 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered: |
JPH-203 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
2094.3 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32198649/ |
60 mg/m² single, intravenous dose: 60 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered: |
JPH-203 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
|
3022.5 ng × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/32198649/ |
85 mg/m² single, intravenous dose: 85 mg/m² route of administration: Intravenous experiment type: SINGLE co-administered: |
JPH-203 plasma | Homo sapiens population: UNHEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN |
| Name | Type | Language | ||
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Official Name | English | ||
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Preferred Name | English | ||
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Code | English | ||
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Common Name | English | ||
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| Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
872522
Created by
admin on Tue Apr 01 17:48:50 GMT 2025 , Edited by admin on Tue Apr 01 17:48:50 GMT 2025
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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JPH-203
Created by
admin on Tue Apr 01 17:48:50 GMT 2025 , Edited by admin on Tue Apr 01 17:48:50 GMT 2025
|
PRIMARY | MedKoo CAT#: 406760; CAS#: 1037592-40-7;Description: JPH203, also known as KYT-0353, is a potent and selective LAT1 selective ( L-type amino acid transporter 1) inhibitor. JPH203 can very potently inhibit l-leucine uptake. JPH203 inhibits YD-38 cell growth. JPH203 up-regulated the population of apoptotic YD-38 cells through the activation of apoptotic factors, including caspases and PARP. (last updated: 7/13/2016). | ||
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300000032239
Created by
admin on Tue Apr 01 17:48:50 GMT 2025 , Edited by admin on Tue Apr 01 17:48:50 GMT 2025
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PRIMARY | |||
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24853505
Created by
admin on Tue Apr 01 17:48:50 GMT 2025 , Edited by admin on Tue Apr 01 17:48:50 GMT 2025
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PRIMARY | |||
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C179105
Created by
admin on Tue Apr 01 17:48:50 GMT 2025 , Edited by admin on Tue Apr 01 17:48:50 GMT 2025
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PRIMARY | |||
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CEDO9QXYZK
Created by
admin on Tue Apr 01 17:48:50 GMT 2025 , Edited by admin on Tue Apr 01 17:48:50 GMT 2025
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PRIMARY | |||
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1037592-40-7
Created by
admin on Tue Apr 01 17:48:50 GMT 2025 , Edited by admin on Tue Apr 01 17:48:50 GMT 2025
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PRIMARY | |||
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11602
Created by
admin on Tue Apr 01 17:48:50 GMT 2025 , Edited by admin on Tue Apr 01 17:48:50 GMT 2025
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PRIMARY | INN |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
