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Details

Stereochemistry ACHIRAL
Molecular Formula C10H8O5
Molecular Weight 208.1675
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FRAXETIN

SMILES

COC1=C(O)C(O)=C2OC(=O)C=CC2=C1

InChI

InChIKey=HAVWRBANWNTOJX-UHFFFAOYSA-N
InChI=1S/C10H8O5/c1-14-6-4-5-2-3-7(11)15-10(5)9(13)8(6)12/h2-4,12-13H,1H3

HIDE SMILES / InChI

Approval Year

PubMed

PubMed

TitleDatePubMed
Antioxidant activity of Fraxetin: in vivo and ex vivo parameters in normal situation versus induced stress.
2001 Jul
Mono- and dinuclear ruthenium carbonyl complexes with redox-active dioxolene ligands: electrochemical and spectroscopic studies and the properties of the mixed-valence complexes.
2003 Dec 1
Suppression of lipid hydroperoxide-induced oxidative damage to cellular DNA by esculetin.
2003 Jun
Neuroprotective effect of fraxetin and myricetin against rotenone-induced apoptosis in neuroblastoma cells.
2004 May 29
Isolation and purification of coumarin compounds from Cortex fraxinus by high-speed counter-current chromatography.
2005 Apr 29
Bone morphogenetic protein-2 and -4 (BMP-2 and -4) mediates fraxetin-induced maturation and differentiation in human osteoblast-like cell lines.
2006 Jan
Fraxetin inhibits the induction of anti-Fas IgM, tumor necrosis factor-alpha and interleukin-1beta-mediated apoptosis by Fas pathway inhibition in human osteoblastic cell line MG-63.
2006 Jul
Metabolic fate of fraxin administered orally to rats.
2006 May
A new C9 nor-isoprenoid glucoside from Rantherium suaveolens.
2007 Aug
[Studies on chemical constituents of Sarcandra glabra].
2008 Apr
[Studies on chemical constituents from stem barks of Fraxinus paxiana].
2008 Aug
An in vitro screening cascade to identify neuroprotective antioxidants in ALS.
2009 Apr 15
Dual anti-oxidative effects of fraxetin isolated from Fraxinus rhinchophylla.
2009 Sep
Inhibitory effects of coumarins from the stem barks of Fraxinus rhynchophylla on adipocyte differentiation in 3T3-L1 cells.
2010
Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model.
2010 Apr 30
Antioxidant activities of coumarins from Korean medicinal plants and their structure-activity relationships.
2010 Jan
Patents
Name Type Language
FRAXETIN
MI  
Common Name English
7,8-DIHYDROXY-6-METHOXY-2H-1-BENZOPYRAN-2-ONE
Systematic Name English
FRAXETIN [MI]
Common Name English
7,8-DIHYDROXY-6-METHOXYCOUMARIN
Systematic Name English
Code System Code Type Description
MESH
C105671
Created by admin on Fri Dec 15 18:36:10 GMT 2023 , Edited by admin on Fri Dec 15 18:36:10 GMT 2023
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PUBCHEM
5273569
Created by admin on Fri Dec 15 18:36:10 GMT 2023 , Edited by admin on Fri Dec 15 18:36:10 GMT 2023
PRIMARY
CAS
574-84-5
Created by admin on Fri Dec 15 18:36:10 GMT 2023 , Edited by admin on Fri Dec 15 18:36:10 GMT 2023
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EPA CompTox
DTXSID00205992
Created by admin on Fri Dec 15 18:36:10 GMT 2023 , Edited by admin on Fri Dec 15 18:36:10 GMT 2023
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CHEBI
5169
Created by admin on Fri Dec 15 18:36:10 GMT 2023 , Edited by admin on Fri Dec 15 18:36:10 GMT 2023
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FDA UNII
CD3GD44O3K
Created by admin on Fri Dec 15 18:36:10 GMT 2023 , Edited by admin on Fri Dec 15 18:36:10 GMT 2023
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ECHA (EC/EINECS)
209-376-2
Created by admin on Fri Dec 15 18:36:10 GMT 2023 , Edited by admin on Fri Dec 15 18:36:10 GMT 2023
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MERCK INDEX
m5564
Created by admin on Fri Dec 15 18:36:10 GMT 2023 , Edited by admin on Fri Dec 15 18:36:10 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
Fraxetin
Created by admin on Fri Dec 15 18:36:10 GMT 2023 , Edited by admin on Fri Dec 15 18:36:10 GMT 2023
PRIMARY