Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C10H8O5 |
| Molecular Weight | 208.1675 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=C(OC(=O)C=C2)C(O)=C1O
InChI
InChIKey=HAVWRBANWNTOJX-UHFFFAOYSA-N
InChI=1S/C10H8O5/c1-14-6-4-5-2-3-7(11)15-10(5)9(13)8(6)12/h2-4,12-13H,1H3
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Maple syrup phytochemicals include lignans, coumarins, a stilbene, and other previously unreported antioxidant phenolic compounds. | 2010-11-24 |
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| Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model. | 2010-04-30 |
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| Antioxidant activities of coumarins from Korean medicinal plants and their structure-activity relationships. | 2010-01 |
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| Inhibitory effects of coumarins from the stem barks of Fraxinus rhynchophylla on adipocyte differentiation in 3T3-L1 cells. | 2010 |
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| Natural coumarins as a novel class of neuroprotective agents. | 2009-10 |
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| Dual anti-oxidative effects of fraxetin isolated from Fraxinus rhinchophylla. | 2009-09 |
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| An in vitro screening cascade to identify neuroprotective antioxidants in ALS. | 2009-04-15 |
|
| [Studies on chemical constituents from stem barks of Fraxinus paxiana]. | 2008-08 |
|
| [Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity]. | 2008-07 |
|
| Simultaneous analysis of coumarins and secoiridoids in Cortex Fraxini by high-performance liquid chromatography-diode array detection-electrospray ionization tandem mass spectrometry. | 2008-05-12 |
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| [Studies on chemical constituents of Sarcandra glabra]. | 2008-04 |
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| A new C9 nor-isoprenoid glucoside from Rantherium suaveolens. | 2007-08 |
|
| Fraxetin inhibits the induction of anti-Fas IgM, tumor necrosis factor-alpha and interleukin-1beta-mediated apoptosis by Fas pathway inhibition in human osteoblastic cell line MG-63. | 2006-07 |
|
| Antifungal and antibacterial activities of Mexican tarragon (Tagetes lucida). | 2006-05-17 |
|
| Metabolic fate of fraxin administered orally to rats. | 2006-05 |
|
| Bone morphogenetic protein-2 and -4 (BMP-2 and -4) mediates fraxetin-induced maturation and differentiation in human osteoblast-like cell lines. | 2006-01 |
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| Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine. | 2005-12-15 |
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| Fraxetin prevents rotenone-induced apoptosis by induction of endogenous glutathione in human neuroblastoma cells. | 2005-09 |
|
| Fatality after deliberate ingestion of the pesticide rotenone: a case report. | 2005-06 |
|
| Isolation and purification of coumarin compounds from Cortex fraxinus by high-speed counter-current chromatography. | 2005-04-29 |
|
| Neuroprotective effect of fraxetin and myricetin against rotenone-induced apoptosis in neuroblastoma cells. | 2004-05-29 |
|
| Natural and synthetic coumarin derivatives with anti-inflammatory/ antioxidant activities. | 2004 |
|
| Mono- and dinuclear ruthenium carbonyl complexes with redox-active dioxolene ligands: electrochemical and spectroscopic studies and the properties of the mixed-valence complexes. | 2003-12-01 |
|
| Effect of fraxetin and myricetin on rotenone-induced cytotoxicity in SH-SY5Y cells: comparison with N-acetylcysteine. | 2003-07-04 |
|
| Suppression of lipid hydroperoxide-induced oxidative damage to cellular DNA by esculetin. | 2003-06 |
|
| Protection of coumarins against linoleic acid hydroperoxide-induced cytotoxicity. | 2003-01-06 |
|
| HIV gp41 binding phenolic components from Fraxinus sieboldiana var. angustata. | 2002-11 |
|
| Antioxidant activity of Fraxetin: in vivo and ex vivo parameters in normal situation versus induced stress. | 2001-07 |
| Name | Type | Language | ||
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Common Name | English | ||
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Preferred Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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C105671
Created by
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5273569
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574-84-5
Created by
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DTXSID00205992
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5169
Created by
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CD3GD44O3K
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209-376-2
Created by
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m5564
Created by
admin on Mon Mar 31 19:16:22 GMT 2025 , Edited by admin on Mon Mar 31 19:16:22 GMT 2025
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PRIMARY | Merck Index | ||
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Fraxetin
Created by
admin on Mon Mar 31 19:16:22 GMT 2025 , Edited by admin on Mon Mar 31 19:16:22 GMT 2025
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SUBSTANCE RECORD
