FRAXETIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H8O5
Molecular Weight	208.1675
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=C(O)C(O)=C2OC(=O)C=CC2=C1

InChI

InChIKey=HAVWRBANWNTOJX-UHFFFAOYSA-N

InChI=1S/C10H8O5/c1-14-6-4-5-2-3-7(11)15-10(5)9(13)8(6)12/h2-4,12-13H,1H3

HIDE SMILES / InChI

Approval Year

PubMed

Title	Date	PubMed
Antioxidant activity of Fraxetin: in vivo and ex vivo parameters in normal situation versus induced stress.	2001 Jul	11456117
HIV gp41 binding phenolic components from Fraxinus sieboldiana var. angustata.	2002 Nov	12451497
Protection of coumarins against linoleic acid hydroperoxide-induced cytotoxicity.	2003 Jan 6	12453663
Effect of fraxetin and myricetin on rotenone-induced cytotoxicity in SH-SY5Y cells: comparison with N-acetylcysteine.	2003 Jul 4	12860476
Suppression of lipid hydroperoxide-induced oxidative damage to cellular DNA by esculetin.	2003 Jun	12808296
Isolation and purification of coumarin compounds from Cortex fraxinus by high-speed counter-current chromatography.	2005 Apr 29	15887488
Effect of fraxetin on antioxidant defense and stress proteins in human neuroblastoma cell model of rotenone neurotoxicity. Comparative study with myricetin and N-acetylcysteine.	2005 Dec 15	15904944
Fatality after deliberate ingestion of the pesticide rotenone: a case report.	2005 Jun	15987402
Bone morphogenetic protein-2 and -4 (BMP-2 and -4) mediates fraxetin-induced maturation and differentiation in human osteoblast-like cell lines.	2006 Jan	16394523
Metabolic fate of fraxin administered orally to rats.	2006 May	16724835
Antifungal and antibacterial activities of Mexican tarragon (Tagetes lucida).	2006 May 17	19127719
A new C9 nor-isoprenoid glucoside from Rantherium suaveolens.	2007 Aug	17680498
[Studies on chemical constituents of Sarcandra glabra].	2008 Apr	18619347
[Studies on chemical constituents from stem barks of Fraxinus paxiana].	2008 Aug	19086636
[Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity].	2008 Jul	18841773
An in vitro screening cascade to identify neuroprotective antioxidants in ALS.	2009 Apr 15	19439221
Natural coumarins as a novel class of neuroprotective agents.	2009 Oct	19929804
Dual anti-oxidative effects of fraxetin isolated from Fraxinus rhinchophylla.	2009 Sep	19721227
Inhibitory effects of coumarins from the stem barks of Fraxinus rhynchophylla on adipocyte differentiation in 3T3-L1 cells.	2010	20823583
Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model.	2010 Apr 30	20433710
Antioxidant activities of coumarins from Korean medicinal plants and their structure-activity relationships.	2010 Jan	19468986
Maple syrup phytochemicals include lignans, coumarins, a stilbene, and other previously unreported antioxidant phenolic compounds.	2010 Nov 24	21033720

Patents

Name

Type

Language

FRAXETIN

Common Name

English

7,8-DIHYDROXY-6-METHOXY-2H-1-BENZOPYRAN-2-ONE

Systematic Name

English

FRAXETIN [MI]

Common Name

English

7,8-DIHYDROXY-6-METHOXYCOUMARIN

Systematic Name

English

Code System Code Type Description

MESH

C105671