U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C9H11NO3
Molecular Weight 181.1885
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of STYRAMATE

SMILES

NC(=O)OCC(O)C1=CC=CC=C1

InChI

InChIKey=OCSOHUROTFFTFO-UHFFFAOYSA-N
InChI=1S/C9H11NO3/c10-9(12)13-6-8(11)7-4-2-1-3-5-7/h1-5,8,11H,6H2,(H2,10,12)

HIDE SMILES / InChI
Styramate is a nonsedative skeletal muscle relaxant drug, developed by the Armour Pharmaceutical Company in 1952. The drug induces relaxation of skeletal musculus by interruption of nerve transmission in the spinal cord and brain stem rather than by exerting a blocking effect at the junction between the motor nerves and the muscles. In mouse studies styramate was found to exert a selective antagonism to hindleg extensor tonic spasm, induced by maximal electroshock, pentylenetetrazol, and strychnine sulfate. In the clinic, the drug was used in patients with neurologic and neuromuscular disorders, secondary muscular spasms. Styramate is marketed in South Africa under tradename Sinaxamol.

Approval Year

Doses

Doses

DosePopulationAdverse events​
400 mg 3 times / day multiple, oral
Highest studied dose
Dose: 400 mg, 3 times / day
Route: oral
Route: multiple
Dose: 400 mg, 3 times / day
Sources: Page: p.289
unhealthy, 30 - 83
n = 53
Health Status: unhealthy
Condition: Muscle spasm
Age Group: 30 - 83
Sex: M+F
Population Size: 53
Sources: Page: p.289
Sourcing

Sourcing

Vendor/AggregatorIDURL
Name Type Language
STYRAMATE
INN   MART.   MI   VANDF   WHO-DD  
INN  
Official Name English
STYRAMATE [VANDF]
Common Name English
1,2-ETHANEDIOL, 1-PHENYL-, 2-CARBAMATE
Systematic Name English
Styramate [WHO-DD]
Common Name English
MYOSPAZ
Common Name English
SINAXAR
Common Name English
2-HYDROXY-2-PHENYLETHYL CARBAMATE
Common Name English
styramate [INN]
Common Name English
NSC-115889
Code English
LINAXAR
Brand Name English
.BETA.-HYDROXYPHENETHYL CARBAMATE
Common Name English
STYRAMATE [MI]
Common Name English
STYRAMATE [MART.]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C264
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
WHO-ATC M03BA04
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
NCI_THESAURUS C29696
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
WHO-VATC QM03BA04
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
Code System Code Type Description
FDA UNII
CBK7Y28SP3
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
PRIMARY
CAS
94-35-9
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
PRIMARY
PUBCHEM
7186
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
PRIMARY
NCI_THESAURUS
C152442
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
PRIMARY
EPA CompTox
DTXSID40861692
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
PRIMARY
NSC
115889
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
PRIMARY
EVMPD
SUB10660MIG
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
PRIMARY
ECHA (EC/EINECS)
202-326-0
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
PRIMARY
SMS_ID
100000083505
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
PRIMARY
WIKIPEDIA
STYRAMATE
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
PRIMARY
MERCK INDEX
m483
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
PRIMARY Merck Index
INN
874
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
PRIMARY
RXCUI
89818
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
PRIMARY RxNorm
DRUG CENTRAL
2485
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
PRIMARY
ChEMBL
CHEMBL2104534
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
PRIMARY
DRUG BANK
DB13357
Created by admin on Fri Dec 15 18:48:39 GMT 2023 , Edited by admin on Fri Dec 15 18:48:39 GMT 2023
PRIMARY