Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | Cr2O7.2Na |
| Molecular Weight | 261.9675 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[Na+].[O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O
InChI
InChIKey=KIEOKOFEPABQKJ-UHFFFAOYSA-N
InChI=1S/2Cr.2Na.7O/q;;2*+1;;;;;;2*-1
Sodium dichromate is an inorganic compound, containing hexavalent chromium. It is highly corrosive and is a strong oxidizing agent. Sodium dichromate is mainly used to produce other chromium compounds but is also used in drilling muds, in metal treatments, in wood preservatives, in the production of dyes and organic chemicals and as a corrosion inhibitor. Sodium dichromate primarily affects the respiratory system causing ulcerations, shortness of breath, bronchitis, pneumonia, and asthma but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Hepatoprotective effect of Taraxacum officinale leaf extract on sodium dichromate-induced liver injury in rats. | 2016-03 |
|
| Human bronchial epithelial BEAS-2B cells, an appropriate in vitro model to study heavy metals induced carcinogenesis. | 2015-09-15 |
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| Temporal changes in rat liver gene expression after acute cadmium and chromium exposure. | 2015 |
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| Whole adult organism transcriptional profiling of acute metal exposures in male zebrafish. | 2014-03-10 |
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| Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelia. | 2012-07-15 |
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| Long-term exposure to hexavalent chromium inhibits expression of tumor suppressor genes in cultured cells and in mice. | 2012-06 |
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| Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90days of exposure to hexavalent chromium in drinking water. | 2012-02-15 |
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| Comparison of the effects of hexavalent chromium in the alimentary canal of F344 rats and B6C3F1 mice following exposure in drinking water: implications for carcinogenic modes of action. | 2012-01 |
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| Inhibitory effect of SJSZ glycoprotein (38 kDa) on expression of heat shock protein 27 and 70 in chromium (VI)-treated hepatocytes. | 2012-01 |
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| Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium. | 2011-09 |
|
| Transcriptional responses in neonate and adult Daphnia magna in relation to relative susceptibility to genotoxicants. | 2011-08 |
|
| The dual roles of c-Jun NH2-terminal kinase signaling in Cr(VI)-induced apoptosis in JB6 cells. | 2011-02 |
|
| Hexavalent chromium inhibited the expression of RKIP of heart in vivo and in vitro. | 2011-02 |
|
| Exposure to nickel, chromium, or cadmium causes distinct changes in the gene expression patterns of a rat liver derived cell line. | 2011 |
|
| Cr(VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells. | 2010-06-01 |
|
| Nitric oxide-mediated bcl-2 stabilization potentiates malignant transformation of human lung epithelial cells. | 2010-05 |
|
| Comparison of the preventive effect of vitamin C and E on hexavalent chromium induced pulmonary fibrosis in rat. | 2008-08 |
|
| Superoxide-mediated proteasomal degradation of Bcl-2 determines cell susceptibility to Cr(VI)-induced apoptosis. | 2008-08 |
|
| Identification of human cell responses to hexavalent chromium. | 2007-10 |
|
| NTP toxicity studies of sodium dichromate dihydrate (CAS No. 7789-12-0) administered in drinking water to male and female F344/N rats and B6C3F1 mice and male BALB/c and am3-C57BL/6 mice. | 2007-01 |
|
| Interindividual variability in response to sodium dichromate-induced oxidative DNA damage: role of the Ser326Cys polymorphism in the DNA-repair protein of 8-oxo-7,8-dihydro-2'-deoxyguanosine DNA glycosylase 1. | 2005-02 |
|
| Genomic and proteomic profiling of responses to toxic metals in human lung cells. | 2003-05 |
|
| Selective induction of gene expression in rat lung by hexavalent chromium. | 2002-10 |
|
| Induction of apoptosis in the lung but not in the liver of rats receiving intra-tracheal instillations of chromium(VI). | 2002-04 |
|
| Down-regulation of the DNA-repair endonuclease 8-oxo-guanine DNA glycosylase 1 (hOGG1) by sodium dichromate in cultured human A549 lung carcinoma cells. | 2002-01 |
|
| LLU-alpha, an endogenous metabolite of gamma-tocopherol, is more effective against metal nephrotoxicity in rats than gamma-tocopherol. | 2001-07-06 |
|
| Chromium (VI)-induced oxidative stress, apoptotic cell death and modulation of p53 tumor suppressor gene. | 2001-06 |
|
| The role of hydroxyl radical as a messenger in Cr(VI)-induced p53 activation. | 2000-09 |
|
| Thiol-reactive metal compounds inhibit NF-kappa B activation by blocking I kappa B kinase. | 2000-06-01 |
|
| Role of p53 tumor suppressor gene in the toxicity of TCDD, endrin, naphthalene, and chromium (VI) in liver and brain tissues of mice. | 2000-03-15 |
|
| Inhibition of protein synthesis by chromium(VI) differentially affects expression of urokinase and its receptor in human type II pneumocytes. | 1999-08-01 |
|
| Differential effects of arsenic(III) and chromium(VI) on nuclear transcription factor binding. | 1999-07 |
|
| Effects of Cr(VI) on the expression of the oxidative stress genes in human lung cells. | 1998-08 |
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NCI_THESAURUS |
C44357
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EPA PESTICIDE CODE |
68304
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m10014
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C016104
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234-190-3
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DTXSID8021274
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SODIUM DICHROMATE
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C45888
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SUBSTANCE RECORD
