U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C22H27NO
Molecular Weight 321.4559
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SEQUIFENADINE

SMILES

CC1=C(C=CC=C1)C(O)(C2CN3CCC2CC3)C4=C(C)C=CC=C4

InChI

InChIKey=OXDOWGVJMITMJL-UHFFFAOYSA-N
InChI=1S/C22H27NO/c1-16-7-3-5-9-19(16)22(24,20-10-6-4-8-17(20)2)21-15-23-13-11-18(21)12-14-23/h3-10,18,21,24H,11-15H2,1-2H3

HIDE SMILES / InChI
Sequifenadine is H1- and 5HT-serotonine receptor antagonist. It has an anti-histamine effect, not only blocking histamine receptors, but also reducing the content of histamine in tissues by accelerating its destruction by diamine oxidase. Sequifenadine did not demonstrate any significant sedative effect. It has a pronounced and prolonged antipruritic and antiexudative effect. It is indicated for the treatment of allergic rhinitis and conjunctivitis, pollinosis, urticaria, angioedema, allergic pruritic dermatosis, including atopic dermatitis. Adverse effects are: dry mouth, pain in the epigastric region, dyspepsia, increased appetite, headache, sleepiness.

Approval Year

Sample Use Guides

50-100 mg 2-3 times per day. The course of treatment is 5-15 days.
Route of Administration: Oral
Name Type Language
SEQUIFENADINE
INN   MART.   WHO-DD  
INN  
Official Name English
Sequifenadine [WHO-DD]
Common Name English
SEQUIFENADINE [MART.]
Common Name English
sequifenadine [INN]
Common Name English
Classification Tree Code System Code
WHO-VATC QR06AX32
Created by admin on Sat Dec 16 16:12:51 GMT 2023 , Edited by admin on Sat Dec 16 16:12:51 GMT 2023
NCI_THESAURUS C29578
Created by admin on Sat Dec 16 16:12:51 GMT 2023 , Edited by admin on Sat Dec 16 16:12:51 GMT 2023
WHO-ATC R06AX32
Created by admin on Sat Dec 16 16:12:51 GMT 2023 , Edited by admin on Sat Dec 16 16:12:51 GMT 2023
NCI_THESAURUS C66885
Created by admin on Sat Dec 16 16:12:51 GMT 2023 , Edited by admin on Sat Dec 16 16:12:51 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C73063
Created by admin on Sat Dec 16 16:12:51 GMT 2023 , Edited by admin on Sat Dec 16 16:12:51 GMT 2023
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FDA UNII
C7Q3TBR3FP
Created by admin on Sat Dec 16 16:12:51 GMT 2023 , Edited by admin on Sat Dec 16 16:12:51 GMT 2023
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DRUG BANK
DB13566
Created by admin on Sat Dec 16 16:12:51 GMT 2023 , Edited by admin on Sat Dec 16 16:12:51 GMT 2023
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INN
6039
Created by admin on Sat Dec 16 16:12:51 GMT 2023 , Edited by admin on Sat Dec 16 16:12:51 GMT 2023
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DRUG CENTRAL
4803
Created by admin on Sat Dec 16 16:12:51 GMT 2023 , Edited by admin on Sat Dec 16 16:12:51 GMT 2023
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EVMPD
SUB10488MIG
Created by admin on Sat Dec 16 16:12:51 GMT 2023 , Edited by admin on Sat Dec 16 16:12:51 GMT 2023
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CAS
57734-69-7
Created by admin on Sat Dec 16 16:12:51 GMT 2023 , Edited by admin on Sat Dec 16 16:12:51 GMT 2023
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PUBCHEM
42553
Created by admin on Sat Dec 16 16:12:51 GMT 2023 , Edited by admin on Sat Dec 16 16:12:51 GMT 2023
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SMS_ID
100000084134
Created by admin on Sat Dec 16 16:12:51 GMT 2023 , Edited by admin on Sat Dec 16 16:12:51 GMT 2023
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ChEMBL
CHEMBL2105505
Created by admin on Sat Dec 16 16:12:51 GMT 2023 , Edited by admin on Sat Dec 16 16:12:51 GMT 2023
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