U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C36H28N6O10
Molecular Weight 704.6417
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLUNICATE

SMILES

O=C(N[C@H]1[C@H](OC(=O)C2=CC=CN=C2)O[C@H](COC(=O)C3=CC=CN=C3)[C@@H](OC(=O)C4=CC=CN=C4)[C@@H]1OC(=O)C5=CC=CN=C5)C6=CC=CN=C6

InChI

InChIKey=ZLNMZWDQJJAEAM-QPBDZWBWSA-N
InChI=1S/C36H28N6O10/c43-31(22-6-1-11-37-16-22)42-28-30(51-34(46)25-9-4-14-40-19-25)29(50-33(45)24-8-3-13-39-18-24)27(21-48-32(44)23-7-2-12-38-17-23)49-36(28)52-35(47)26-10-5-15-41-20-26/h1-20,27-30,36H,21H2,(H,42,43)/t27-,28-,29-,30-,36+/m1/s1

HIDE SMILES / InChI
Glunicate (LG 13979) is a long-acting nicotinic acid derivative that can lower plasma triglyceride levels, while leaving other lipoprotein parameters unaffected. It exerts a dose‐dependent reduction of plasma triglycerides and cholesterol. In rabbits, glunicate provided dose-dependent protection of the arterial wall from atheromatous lesions and from cholesterol and collagen accumulation. It has been shown that glunicate has prolonged activity on plasma free fatty acids and triglycerides, with long lasting and intense activity on plasma cholesterol.

Approval Year

Patents

Patents

Name Type Language
GLUNICATE
INN   MART.  
INN  
Official Name English
glunicate [INN]
Common Name English
2-DEOXY-2-NICOTINAMIDO-.BETA.-D-GLUCOPYRANOSE 1,3,4,6-TETRANICOTINATE
Common Name English
GLUNICATE [MART.]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C98151
Created by admin on Fri Dec 15 16:08:45 GMT 2023 , Edited by admin on Fri Dec 15 16:08:45 GMT 2023
Code System Code Type Description
SMS_ID
100000084209
Created by admin on Fri Dec 15 16:08:45 GMT 2023 , Edited by admin on Fri Dec 15 16:08:45 GMT 2023
PRIMARY
FDA UNII
C62ZH19B0L
Created by admin on Fri Dec 15 16:08:45 GMT 2023 , Edited by admin on Fri Dec 15 16:08:45 GMT 2023
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EVMPD
SUB07942MIG
Created by admin on Fri Dec 15 16:08:45 GMT 2023 , Edited by admin on Fri Dec 15 16:08:45 GMT 2023
PRIMARY
ChEMBL
CHEMBL2106431
Created by admin on Fri Dec 15 16:08:45 GMT 2023 , Edited by admin on Fri Dec 15 16:08:45 GMT 2023
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EPA CompTox
DTXSID201001487
Created by admin on Fri Dec 15 16:08:45 GMT 2023 , Edited by admin on Fri Dec 15 16:08:45 GMT 2023
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NCI_THESAURUS
C87632
Created by admin on Fri Dec 15 16:08:45 GMT 2023 , Edited by admin on Fri Dec 15 16:08:45 GMT 2023
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CAS
80763-86-6
Created by admin on Fri Dec 15 16:08:45 GMT 2023 , Edited by admin on Fri Dec 15 16:08:45 GMT 2023
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PUBCHEM
6917785
Created by admin on Fri Dec 15 16:08:45 GMT 2023 , Edited by admin on Fri Dec 15 16:08:45 GMT 2023
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INN
5483
Created by admin on Fri Dec 15 16:08:45 GMT 2023 , Edited by admin on Fri Dec 15 16:08:45 GMT 2023
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MESH
C038986
Created by admin on Fri Dec 15 16:08:45 GMT 2023 , Edited by admin on Fri Dec 15 16:08:45 GMT 2023
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