Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C4H6NO4.Na.H2O |
| Molecular Weight | 173.0998 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.[Na+].OC(=O)CNCC([O-])=O
InChI
InChIKey=XMBFRMVQIVTRJX-UHFFFAOYSA-M
InChI=1S/C4H7NO4.Na.H2O/c6-3(7)1-5-2-4(8)9;;/h5H,1-2H2,(H,6,7)(H,8,9);;1H2/q;+1;/p-1
Disodium iminodiacetate is a salt of iminodiacetic acid (IDA). The iminodiacetate anion can act as a tridentate ligand to form a metal complex with two, fused, five-membered chelate rings. Iminodiacetic acid is used to diagnose problems of the liver, gallbladder and bile ducts in an imaging procedure, called as hepatobiliary iminodiacetic acid (HIDA) scan. A nuclear medicine scanner tracks the flow of the tracer from the liver into the gallbladder and small intestine and creates computer images. In addition, iminodiacetate is a part of the iminodiacetate-modified poly-L-lysine dendrimer (IMPLD), a fluorescent bone-imaging agent. IMPLD is used in the diagnosis of bone tumors, or to be used for the delivery of chemotherapy drugs or therapeutic agents. Bones differ from other body tissues in their unique calcium mineral composition, which consists mainly of hydroxyapatite (HA). IDA functionalization could be used as a general approach to bone targeting by increasing affinity for HA, enabling the transport of other molecules or particles to bones.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Removal of metallic impurities from mobile phases in reversed-phase high-performance liquid chromatography by the use of an in-line chelation column. | 2001 Apr 13 |
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| Determination of trace alkaline earth metals in brines using chelation ion chromatography with an iminodiacetic acid bonded silica column. | 2001 Jan 12 |
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| Synthesis of a polymerizable metal-ion-chelating lipid for fluid bilayers. | 2001 Jul 13 |
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| Structural studies of lanthanide (III) complexes with oxydiacetic acid and iminodiacetic acid in aqueous solution by EXAFS. | 2001 Mar 1 |
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| Sensitive and selective ion chromatographic method for the determination of trace beryllium in water samples. | 2001 Mar 2 |
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| Dimeric W3SO3 cluster complexes: synthesis, characterization, and potential applications as X-ray contrast agents. | 2001 Mar 26 |
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| Determination of silver speciation in natural waters. 1. Laboratory tests of Chelex-100 chelating resin as a competing ligand. | 2001 May 15 |
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| Comparison of histidine-tag capture chemistries for purification following chemical extraction. | 2002 Apr 12 |
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| Convection-aided collection of metal ions using chelating porous flat-sheet membranes. | 2002 Apr 19 |
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| Novel resorcinarene-based pH-triggered gelator. | 2002 Dec 7 |
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| Iminodiacetate and nitrilotriacetate degradation by Kluyveromyces marxianus IMB3. | 2002 Jan 18 |
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| Erythropoietin mimetics derived from solution phase combinatorial libraries. | 2002 Jan 30 |
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| Inductively coupled plasma mass spectrometric determination of heavy metals in sea-water samples after pre-treatment with a chelating resin disk by an on-line flow injection method. | 2002 Jun |
|
| A novel series of complexones with bis- or biazole structure as mixed ligands of paramagnetic contrast agents for MRI. | 2003 Dec 1 |
|
| Use of complexing agents for effective ion-exchange separation of Co(II)/Ni(II) from aqueous solutions. | 2003 Feb |
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| Does this patient have acute cholecystitis? | 2003 Jan 1 |
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| Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating succinyl hydroxamate and iminodiacetic acid hydroxamate moieties. | 2003 Jun |
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| A comparative study of two chelating ion-exchange resins for the removal of chromium(III) from aqueous solution. | 2003 Jun 27 |
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| Analysis of protein adsorption on regenerated cellulose-based immobilized copper ion affinity membranes. | 2003 May 9 |
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| Nucleic acid separations utilizing immobilized metal affinity chromatography. | 2003 May-Jun |
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| Immobilized metal-ion chelating capillary microreactor for peptide mapping analysis of proteins by matrix assisted laser desorption/ ionization-time of flight-mass spectrometry. | 2003 Nov |
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| Cd(II) sensing in water using novel aromatic iminodiacetate based fluorescent chemosensors. | 2003 Oct 30 |
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| Hexafluoroacetone as protecting and activating reagent: site-selective functionalization of iminodiacetic acid. | 2004 Dec |
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| Alternative quality control for technetium-99m IDA complexes. | 2004 Dec |
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| Control of peptide structure and recognition by Fe(III)-induced helix destabilization. | 2004 Dec 8 |
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| Chemical extraction and direct adsorptive purification of recombinant human antigen Ro52. | 2004 May |
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| A single-step chromatographic method for the purification of proteins devoid of exposed histidine residues. | 2004 May |
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| Aqua(2,2'-bi-1H-imidazole)chlorocopper(II) chloro(iminodiacetato)copper(II) monohydrate. | 2005 Jan |
|
| Speciation of chromium(III) and cobalt(III) (amino)carboxylate complexes using capillary electrophoresis. | 2005 Jan 1 |
|
| Multivalent carbocyanine molecular probes: synthesis and applications. | 2005 Jan-Feb |
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71586841
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DTXSID10208858
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m6229
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C5JB6OQ1PL
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6011-32-1
Created by
admin on Sat Dec 16 05:42:01 GMT 2023 , Edited by admin on Sat Dec 16 05:42:01 GMT 2023
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