Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H3NO |
| Molecular Weight | 57.0513 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN=C=O
InChI
InChIKey=HAMGRBXTJNITHG-UHFFFAOYSA-N
InChI=1S/C2H3NO/c1-3-2-4/h1H3
Methyl isocyanate (MIC) is a noxious industrial chemical used extensively in the production of carbamate pesticides. This compound is a respiratory toxicant. Recently published studies have shown that methyl isocyanate can lead to epigenetic alterations due to its strong binding with DNA methyltransferase 1 (DNMT1) which is responsible for maintenance of normal methylation, cell growth and survival in mammals.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Sequential respiratory, psychologic, and immunologic studies in relation to methyl isocyanate exposure over two years with model development. | 1992 Jul |
|
| Two rotors potential scans and vibrational assignments for dihalomethylsulfonyl isocyanates. | 2002 Mar 15 |
|
| Exposure to airborne isocyanates and other thermal degradation products at polyurethane-processing workplaces. | 2002 Oct |
|
| Development of a diffusive sampling method for determination of methyl isocyanate in air. | 2002 Oct |
|
| The Bhopal syndrome: persistent questions about acute toxicity and management of gas victims. | 2002 Oct-Dec |
|
| Bhopal's health disaster continues to unfold. | 2002 Sep 14 |
|
| Environmental threats to children's health in Southeast Asia and the Western Pacific. | 2003 Aug |
|
| Diffusive sampling of methyl isocyanate using 4-nitro-7-piperazinobenzo-2-oxa-1,3-diazole (NBDPZ) as derivatizing agent. | 2003 Feb |
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| 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(methylamino)carbonyl]hydrazine (VNP40101M): II. Role of O6-alkylguanine-DNA alkyltransferase in cytotoxicity. | 2004 Apr |
|
| Revisiting the Bhopal tragedy. | 2004 Dec 3 |
|
| Studies on the methyl isocyanate adducts with globin. | 2004 Jun 30 |
|
| The antineoplastic efficacy of the prodrug Cloretazine is produced by the synergistic interaction of carbamoylating and alkylating products of its activation. | 2005 |
|
| Life-threatening intoxication with methylene bis(thiocyanate): clinical picture and pitfalls. A case report. | 2006 Apr 11 |
|
| Determination of airborne isocyanates generated during the thermal degradation of car paint in body repair shops. | 2006 Jun |
|
| Validation of a diffusive sampling method for airborne low-molecular isocyanates using 4-nitro-7-piperazinobenzo-2-oxa-1,3-diazole-impregnated filters and liquid chromatography-tandem mass spectrometry. | 2006 Nov 17 |
|
| Effects of humidity and filter material on diffusive sampling of isocyanates using reagent-coated filters. | 2006 Oct |
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| Identification of potential genomic biomarkers of hepatotoxicity caused by reactive metabolites of N-methylformamide: Application of stable isotope labeled compounds in toxicogenomic studies. | 2006 Oct |
|
| Abstracts of papers presented at the 2007 pittsburgh conference. | 2007 |
|
| Ocular effects of exposure to industrial chemicals: clinical management and proteomic approaches to damage assessment. | 2007 |
|
| Phase II study of Cloretazine for the treatment of adults with recurrent glioblastoma multiforme. | 2007 Jan |
|
| Social determinants of the health of urban populations: methodologic considerations. | 2007 May |
|
| Evaluation and application of the RD50 for determining acceptable exposure levels of airborne sensory irritants for the general public. | 2007 Nov |
|
| Slum health: from understanding to action. | 2007 Oct |
|
| Representation and re-presentation in litigation science. | 2008 Jan |
|
| Overseas experience in global health: travels to Bhopal, India, 20 years after the Union Carbide disaster. | 2008 Jan |
|
| Aftermath of the Bhopal accident. | 2008 Jun 7 |
|
| Validation of transferability of DBA derivatization and LC-MS/MS determination method for isocyanates via an interlaboratory comparison. | 2008 Nov |
|
| A case of isocyanate-induced asthma possibly complicated by food allergy after peanut consumption: a case report. | 2008 Nov 26 |
|
| Isocyanates induces DNA damage, apoptosis, oxidative stress, and inflammation in cultured human lymphocytes. | 2008 Nov-Dec |
|
| Initial testing of VNP40101M (Cloretazine) by the pediatric preclinical testing program. | 2008 Sep |
|
| Identification and fragmentation pathways of caffeine metabolites in urine samples via liquid chromatography with positive electrospray ionization coupled to a hybrid quadrupole linear ion trap (LTQ) and Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry. | 2009 Apr |
|
| Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. | 2009 Apr |
|
| Inflammatory response to isocyanates and onset of genomic instability in cultured human lung fibroblasts. | 2009 Feb 10 |
|
| Laromustine, a sulfonyl hydrolyzing alkylating prodrug for cancer therapy. | 2009 Jan |
|
| Respiratory symptoms and lung function in foundry workers exposed to low molecular weight isocyanates. | 2009 Jun |
|
| Analysis of cellular response to isocyanate using N-succinimidyl N-methylcarbamate exposure in cultured mammalian cells. | 2009 May |
|
| Clinical activity of laromustine (Onrigin™) in hematologic malignancies. | 2009 Oct |
|
| Investigating genetic outcomes following 1984 Toxic Union Carbide disaster in India: epidemiological challenges. | 2010 |
|
| [The Bhopal tragedy 25 (10+15) years after]. | 2010 Apr-Jun |
|
| 25 years after the Bhopal gas tragedy. | 2010 Jan-Feb |
|
| Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures. | 2010 Jul |
|
| Bhopal. India launches new probe of cyanide disaster. | 2010 Jul 2 |
|
| Different experimental approaches in modelling cataractogenesis: An overview of selenite-induced nuclear cataract in rats. | 2010 Mar |
|
| Molecular mechanisms of isocyanate induced oncogenic transformation in ovarian epithelial cells. | 2010 Nov |
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624-83-9
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SUBSTANCE RECORD
