GLYCYCLAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H20N2O3S
Molecular Weight	296.385
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC2CCCCC2

InChI

InChIKey=RIGBPMDIGYBTBJ-UHFFFAOYSA-N

InChI=1S/C14H20N2O3S/c1-11-7-9-13(10-8-11)20(18,19)16-14(17)15-12-5-3-2-4-6-12/h7-10,12H,2-6H2,1H3,(H2,15,16,17)

HIDE SMILES / InChI

Description
Sources: http://www.drugfuture.com/chemdata/tolcyclamide.html | https://books.google.ru/books?id=FC9pDtB_tz0C&pg=PA201&lpg=PA201&dq=GLYCYCLAMIDE retrieved from Progress in Medicinal Chemistry, Volume 18, p.202

Glycyclamide (Tolcyclamide) isn a cyclohexyl-containing sulfonylurea compound with antihyperglycemic activity. Tolcyclamide is closely related to tolbutamide, with a cyclohexyl ring in place of the butyl group. It is much less potent than glipizide, being active at a daily dose of 1000 mg.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Type 2 diabetes mellitus 259 Sources: http://diabetes.diabetesjournals.org/content/10/4/325 https://www.ncbi.nlm.nih.gov/pubmed/13733497	Primary		Approved 8429	Diaboral Approved Use Treatment of type 2 diabetes mellitus

PubMed

Title	Date	PubMed
Synthesis, characterization, antioxidant activity, and DNA-binding studies of 1-cyclohexyl-3-tosylurea and its Nd(III), Eu(III) complexes.	2008 Apr	18379105
Synthesis of a high-purity chemical library reveals a potent inducer of oxidative stress.	2010 Jun 14	20461745

Patents

Sample Use Guides

In Vivo Use Guide

Daily dose for diabetes treatment is 500-1500 mg

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

GLYCYCLAMIDE

Official Name

English

K-386

Code

English

TOLCYCLAMIDE [MI]

Common Name

English

Glycyclamide [WHO-DD]

Common Name

English

K-38

Code

English

1-CYCLOHEXYL-3-P-TOLYLSULFONYLUREA

Common Name

English

GLYCYCLAMIDE [MART.]

Common Name

English

NSC-142661

Code

English

glycyclamide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C97936