Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C36H30O16 |
| Molecular Weight | 718.6138 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)[C@@H](CC1=CC=C(O)C(O)=C1)OC(=O)\C=C\C2=C3[C@@H]([C@H](OC3=C(O)C=C2)C4=CC=C(O)C(O)=C4)C(=O)O[C@H](CC5=CC=C(O)C(O)=C5)C(O)=O
InChI
InChIKey=SNKFFCBZYFGCQN-VWUOOIFGSA-N
InChI=1S/C36H30O16/c37-20-6-1-16(11-24(20)41)13-27(34(45)46)50-29(44)10-5-18-3-9-23(40)33-30(18)31(32(52-33)19-4-8-22(39)26(43)15-19)36(49)51-28(35(47)48)14-17-2-7-21(38)25(42)12-17/h1-12,15,27-28,31-32,37-43H,13-14H2,(H,45,46)(H,47,48)/b10-5+/t27-,28-,31+,32-/m1/s1
Salvianolic acid B is a bioactive molecule isolated from Radix Salviae Miltiorrhizae. The compound shows high antioxidant and free radical scavenging activities. It is a major component of the commercial Fufang Danshen products (Compound Danshen Dripping Pill, the Danshen Pian, and the Danshen Injection, ICP), used for the treatment of angina pectoris, and other heart diseases.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Effects of salvianolic acid B on expressions of TGF-beta1 and its receptors in liver of rats with dimethylnitrosamine-induced hepatic fibrosis]. | 2005 Jul |
|
| In vitro anti-fibrotic activities of herbal compounds and herbs. | 2009 Oct |
|
| Salvianolic acid B protects SH-SY5Y neuroblastoma cells from 1-methyl-4-phenylpyridinium-induced apoptosis. | 2010 |
|
| Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats. | 2010 Jan 15 |
|
| Salvianolic acid B inhibits the TLR4-NFκB-TNFα pathway and attenuates neonatal rat cardiomyocyte injury induced by lipopolysaccharide. | 2011 Oct |
|
| Direct stimulation of adult neural stem/progenitor cells in vitro and neurogenesis in vivo by salvianolic acid B. | 2012 |
|
| Cardioprotective effect of salvianolic acid B against arsenic trioxide-induced injury in cardiac H9c2 cells via the PI3K/Akt signal pathway. | 2013 Feb 4 |
|
| Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats. | 2014 Jul 15 |
Patents
Sample Use Guides
Oral or sublingual application, 2 capsules (ICP) each time, 1 to 2 times daily before meals. Sublingual administration of all the pills from inside the capsule to relieve acute angina pectoris.
Route of Administration:
Oral
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SUBSTANCE RECORD
