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Details

Stereochemistry ABSOLUTE
Molecular Formula C36H30O16
Molecular Weight 718.6138
Optical Activity UNSPECIFIED
Defined Stereocenters 4 / 4
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of SALVIANOLIC ACID B

SMILES

OC(=O)[C@@H](CC1=CC=C(O)C(O)=C1)OC(=O)\C=C\C2=C3[C@@H]([C@H](OC3=C(O)C=C2)C4=CC=C(O)C(O)=C4)C(=O)O[C@H](CC5=CC=C(O)C(O)=C5)C(O)=O

InChI

InChIKey=SNKFFCBZYFGCQN-VWUOOIFGSA-N
InChI=1S/C36H30O16/c37-20-6-1-16(11-24(20)41)13-27(34(45)46)50-29(44)10-5-18-3-9-23(40)33-30(18)31(32(52-33)19-4-8-22(39)26(43)15-19)36(49)51-28(35(47)48)14-17-2-7-21(38)25(42)12-17/h1-12,15,27-28,31-32,37-43H,13-14H2,(H,45,46)(H,47,48)/b10-5+/t27-,28-,31+,32-/m1/s1

HIDE SMILES / InChI

Description

Salvianolic acid B is a bioactive molecule isolated from Radix Salviae Miltiorrhizae. The compound shows high antioxidant and free radical scavenging activities. It is a major component of the commercial Fufang Danshen products (Compound Danshen Dripping Pill, the Danshen Pian, and the Danshen Injection, ICP), used for the treatment of angina pectoris, and other heart diseases.

CNS Activity

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
ICP

PubMed

Sample Use Guides

In Vivo Use Guide
Oral or sublingual application, 2 capsules (ICP) each time, 1 to 2 times daily before meals. Sublingual administration of all the pills from inside the capsule to relieve acute angina pectoris.
Route of Administration: Oral
In Vitro Use Guide
When salvianolic acid B concentration is 2.5, 5, and 10 mg/l, cell viability, and superoxide dismutase (SOD) activity are enhanced, and the formation of malondialdehyde (MDA) in human umbilical vein endothelial cells (ECV304) is inhibited.