Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C22H23FN4O2 |
| Molecular Weight | 394.442 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@H](C1=NOC(NC(=N)N2CCOCC2)=C1)C3=CC=C(C(F)=C3)C4=CC=CC=C4
InChI
InChIKey=MYTIJGWONQOOLC-HNNXBMFYSA-N
InChI=1S/C22H23FN4O2/c1-15(17-7-8-18(19(23)13-17)16-5-3-2-4-6-16)20-14-21(29-26-20)25-22(24)27-9-11-28-12-10-27/h2-8,13-15H,9-12H2,1H3,(H2,24,25)/t15-/m0/s1
Rimacalib (SMP 114) is a prostaglandin E2 antagonist that has been evaluated for use in rheumatoid arthritis. This orally bioavailable compound is a CaMKII inhibitor developed for human use. A phase II clinical trial to compare the effects of rimacalib to placebo in patients with rheumatoid arthritis has been terminated in 2009. Rimacalib also reduces SR Ca2+ leak and was therefore suggested as a candidate drug to treat proarrhythmogenic events in human atrial cardiomyocytes and cardiomyocytes from patients with heart failure.
Originator
Approval Year
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NCI_THESAURUS |
C257
Created by
admin on Mon Mar 31 18:44:15 GMT 2025 , Edited by admin on Mon Mar 31 18:44:15 GMT 2025
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CHEMBL2107772
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8597
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C87325
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DTXSID401351185
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215174-50-8
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BZ76J3N815
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9800765
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DB12571
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100000175055
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ACTIVE MOIETY
