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Details

Stereochemistry ACHIRAL
Molecular Formula C8H5NO3
Molecular Weight 163.1302
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of N-Hydroxyphthalimide

SMILES

ON1C(=O)C2=C(C=CC=C2)C1=O

InChI

InChIKey=CFMZSMGAMPBRBE-UHFFFAOYSA-N
InChI=1S/C8H5NO3/c10-7-5-3-1-2-4-6(5)8(11)9(7)12/h1-4,12H

HIDE SMILES / InChI

Approval Year

PubMed

PubMed

TitleDatePubMed
A metal-free aerobic oxidation of nitrotoluenes catalyzed by N,N',N″-trihydroxyisocyanuric acid (THICA) and a novel approach to the catalyst.
2010-12-15
Fluorous tagged N-hydroxy phthalimide for the parallel synthesis of O-aryloxyamines.
2010-09-13
Novel convenient synthesis of biologically active esters of hydroxylamine.
2010-02
Reactivity and applications of new amine reactive cross-linkers for mass spectrometric detection of protein-protein complexes.
2010-01-01
Mild and selective oxidation of cellulose fibers in the presence of N-hydroxyphthalimide.
2009-08-10
Electron-transfer properties of short-lived N-oxyl radicals. Kinetic study of the reactions of benzotriazole-N-oxyl radicals with ferrocenes. Comparison with the phthalimide-N-oxyl radical.
2009-08-07
The chiral auxiliary N-1-(1'-naphthyl)ethyl-O-tert-butylhydroxylamine: a chiral Weinreb amide equivalent.
2009-08-06
Anthrone-derived NHPI analogues as catalysts in reactions using oxygen as an oxidant.
2008-11-21
Engineering and Applications of fungal laccases for organic synthesis.
2008-11-20
Crystal growth and characterization of N-hydroxyphthalimide (C8H5NO3) crystal.
2008-11-01
Cu-facilitated C-O bond formation using N-hydroxyphthalimide: efficient and selective functionalization of benzyl and allylic C-H bonds.
2008-06-25
Pronounced non-Arrhenius behaviour of hydrogen-abstractions from toluene and derivatives by phthalimide-N-oxyl radicals: a theoretical study.
2008-02-28
Synthesis of N-alkoxyphthalimides under ultrasound irradiation.
2008-01
A kinetic study of the electron-transfer reaction of the phthalimide-N-oxyl radical (PINO) with ferrocenes.
2007-11-09
N-hydroxyimides as efficient ligands for the copper-catalyzed N-arylation of pyrrole, imidazole, and indole.
2007-11-09
Occupational contact dermatitis (drug-induced medicamentosa): six case reports.
2007-11-07
Free radical functionalization of organic compounds catalyzed by N-hydroxyphthalimide.
2007-09
Alpha and beta L-Fucopyranosyl oxyamines: key intermediates for the preparation of fucose-containing glycoconjugates by oxime ligation.
2007-05-21
Elusive forms and structures of N-hydroxyphthalimide: the colorless and yellow crystal forms of N-hydroxyphthalimide.
2007-04-05
Variable C2-symmetric analogues of N-hydroxyphthalimide as enantioselective catalysts for aerobic oxidation: kinetic resolution of oxazolidines.
2007
One-pot synthesis of lactams from cycloalkanes and tert-butyl nitrite by using N-hydroxyphthalimide as key catalyst.
2006-11-20
[Hydroxyphthalimide induced medicamentosa-like dermatitis in five patients].
2006-10
Kinetic study of the hydrogen abstraction reaction of the benzotriazole-N-oxyl radical (BTNO) with H-donor substrates.
2005-11-11
A new supported reagent for the parallel synthesis of primary and secondary O-alkyl hydroxylamines through a base-catalyzed Mitsunobu reaction.
2005-08-05
Application of a dual linker with a reference cleavage site to discover a new reaction between amines and N-hydroxyphthalimide.
2005-07-12
Electron-transfer mechanism in the N-demethylation of N,N-dimethylanilines by the phthalimide-N-oxyl radical.
2005-06-24
Mechanisms of reaction of aminoxyl (nitroxide), iminoxyl, and imidoxyl radicals with alkenes and evidence that in the presence of lead tetraacetate, N-hydroxyphthalimide reacts with alkenes by both radical and nonradical mechanisms.
2005-06-10
Selective organocatalytic oxygenation of hydrocarbons by dioxygen using anthraquinones and N-hydroxyphthalimide.
2005-01-20
Kinetics of self-decomposition and hydrogen atom transfer reactions of substituted phthalimide N-oxyl radicals in acetic acid.
2005-01-07
Reactivity of phthalimide N-oxyl radical (PINO) toward the phenolic O-H bond. A kinetic study.
2004-12-10
Biomimetic catalytic system driven by electron transfer for selective oxygenation of hydrocarbon.
2004-09-01
Novel method for efficient aerobic oxidation of silyl ethers to carbonyl compounds catalyzed with N-hydroxyphthalimide (NHPI) and lipophilic Co(II) complexes.
2004-08-19
Mechanism of the catalytic oxidation of hydrocarbons by N-hydroxyphthalimide: a theoretical study.
2004-05-07
A new route to lactam precursors from cycloalkanes: direct production of nitrosocycloalkanes or cycloalkanone oximes by using tert-butyl nitrite and N-hydroxyphthalimide.
2004-02-20
New efficient aerobic oxidation of some alcohols with dioxygen catalysed by N-hydroxyphtalimide with vanadium co-catalysts.
2004-01-21
Kinetic study of the phthalimide N-oxyl radical in acetic acid. Hydrogen abstraction from substituted toluenes, benzaldehydes, and benzyl alcohols.
2003-11-28
Synthesis of a new heterobifunctional linker, N-[4-(aminooxy)butyl]maleimide, for facile access to a thiol-reactive 18F-labeling agent.
2003-11-20
Controlling mode selectivity in palladium-catalyzed bisdiene carbocyclizations: optimizing for cyclization-trapping over cycloisomerization.
2003-10-02
Oxidation of substituted toluenes with molecular oxygen in the presence of N,N',N' '-trihydroxyisocyanuric acid as a key catalyst.
2003-08-22
Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors.
2003-03-27
Hydroxylamines as oxidation catalysts: thermochemical and kinetic studies.
2003-03-07
Oxidation of phenols by laccase and laccase-mediator systems.
2002-11
An efficient nitration of light alkanes and the alkyl side-chain of aromatic compounds with nitrogen dioxide and nitric acid catalyzed by N-hydroxyphthalimide.
2002-08-09
Aerobic oxidation of N-alkylamides catalyzed by N-hydroxyphthalimide under mild conditions. Polar and enthalpic effects.
2002-04-19
A new, highly selective synthesis of aromatic aldehydes by aerobic free-radical oxidation of benzylic alcohols, catalysed by n-hydroxyphthalimide under mild conditions. Polar and enthalpic effects.
2002-04-07
First Ritter-type reaction of alkylbenzenes using N-hydroxyphthalimide as a key catalyst.
2002-03-07
The radical-chain addition of aldehydes to alkenes by the use of N-hydroxyphthalimide (NHPI) as a polarity-reversal catalyst.
2001-11-21
Catalytic oxyalkylation of alkenes with alkanes and molecular oxygen via a radical process using N-hydroxyphthalimide.
2001-09-21
The copper-mediated cross-coupling of phenylboronic acids and N-hydroxyphthalimide at room temperature: synthesis of aryloxyamines.
2001-01-11
Patents
Name Type Language
N-Hydroxyphthalimide
MI  
Systematic Name English
NSC-770
Preferred Name English
2-HYDROXY-1H-ISOINDOLE-1,3(2H)-DIONE
Systematic Name English
N-HYDROXYPHTHALIMIDE [MI]
Common Name English
2-HYDROXYPHTHALIMIDE
Systematic Name English
PHTHALIMIDE, N-HYDROXY-
Systematic Name English
N-HYDROXYPHTHALAMIDE
Systematic Name English
2-HYDROXYISOINDOLINE-1,3-DIONE
Systematic Name English
2-HYDROXYISOINDOLE-1,3-DIONE
Systematic Name English
Code System Code Type Description
PUBCHEM
10665
Created by admin on Mon Mar 31 21:13:19 GMT 2025 , Edited by admin on Mon Mar 31 21:13:19 GMT 2025
PRIMARY
WIKIPEDIA
N-Hydroxyphthalimide
Created by admin on Mon Mar 31 21:13:19 GMT 2025 , Edited by admin on Mon Mar 31 21:13:19 GMT 2025
PRIMARY
EPA CompTox
DTXSID7060170
Created by admin on Mon Mar 31 21:13:19 GMT 2025 , Edited by admin on Mon Mar 31 21:13:19 GMT 2025
PRIMARY
FDA UNII
BXI99M81X0
Created by admin on Mon Mar 31 21:13:19 GMT 2025 , Edited by admin on Mon Mar 31 21:13:19 GMT 2025
PRIMARY
MESH
C037437
Created by admin on Mon Mar 31 21:13:19 GMT 2025 , Edited by admin on Mon Mar 31 21:13:19 GMT 2025
PRIMARY
ECHA (EC/EINECS)
208-358-1
Created by admin on Mon Mar 31 21:13:19 GMT 2025 , Edited by admin on Mon Mar 31 21:13:19 GMT 2025
PRIMARY
NSC
770
Created by admin on Mon Mar 31 21:13:19 GMT 2025 , Edited by admin on Mon Mar 31 21:13:19 GMT 2025
PRIMARY
CAS
524-38-9
Created by admin on Mon Mar 31 21:13:19 GMT 2025 , Edited by admin on Mon Mar 31 21:13:19 GMT 2025
PRIMARY
MERCK INDEX
m6146
Created by admin on Mon Mar 31 21:13:19 GMT 2025 , Edited by admin on Mon Mar 31 21:13:19 GMT 2025
PRIMARY Merck Index