TIARAMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H18ClN3O3S
Molecular Weight	355.84
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OCCN1CCN(CC1)C(=O)CN2C(=O)SC3=C2C=C(Cl)C=C3

InChI

InChIKey=HTJXMOGUGMSZOG-UHFFFAOYSA-N

InChI=1S/C15H18ClN3O3S/c16-11-1-2-13-12(9-11)19(15(22)23-13)10-14(21)18-5-3-17(4-6-18)7-8-20/h1-2,9,20H,3-8,10H2

HIDE SMILES / InChI

Description
Sources: https://www.astellas.com/en/csr/pdf/astellas_csr2011v3_eg.pdf | http://image.packageinsert.jp/pdf.php?mode=1&yjcode=1148001F1059

Tiaramide is an anti-inflammatory and analgesic drug, which was developed by Fujisawa Pharmaceutical (now Astellas pharma) and used in Japan under the name Solantol for the treatment of different pain and inflammatory disorders. Later on, Astellas recalled the product by reasons other than safety. The mechanism of tiaramide action is unknown.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 619 Sources: http://image.packageinsert.jp/pdf.php?mode=1&yjcode=1148001F1059	Primary		Approved 8583	SOLANTAL Approved Use Pain management after surgery, tooth extraction and trauma, pain relief in arthritis, low back pain, cervical shoulder arm syndrome, pelvic inflammation, birth canal injuries, breast engorgement, herpes zoster, polymorphic exudative erythema, cystitis, epididymitis, uveitis, pericoronitis, acute upper respiratory tract inflammation. Launch Date 1974
Inflammatory diseases 15 Sources: http://image.packageinsert.jp/pdf.php?mode=1&yjcode=1148001F1059	Palliative		Approved 8583	SOLANTOL Approved Use Pain management after surgery, tooth extraction and trauma, pain relief in arthritis, low back pain, cervical shoulder arm syndrome, pelvic inflammation, birth canal injuries, breast engorgement, herpes zoster, polymorphic exudative erythema, cystitis, epididymitis, uveitis, pericoronitis, acute upper respiratory tract inflammation. Launch Date 1974

C_max

Value	Dose	Co-administered	Analyte	Population
1.79 μg/mL OTHER GOV'T https://www.info.pmda.go.jp/go/interview/3/171911_1148001F1059_3_003_1F.pdf#page=18	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:		TIARAMIDE serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
1.7 μg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6125356/	200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered:		TIARAMIDE serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
5.36 μg × h/mL OTHER GOV'T https://www.info.pmda.go.jp/go/interview/3/171911_1148001F1059_3_003_1F.pdf#page=18	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:		TIARAMIDE serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN

T_1/2

Value	Dose	Co-administered	Analyte	Population
1.59 h OTHER GOV'T https://www.info.pmda.go.jp/go/interview/3/171911_1148001F1059_3_003_1F.pdf#page=18	300 mg single, oral dose: 300 mg route of administration: Oral experiment type: SINGLE co-administered:		TIARAMIDE serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
1.34 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/6125356/	200 mg single, oral dose: 200 mg route of administration: Oral experiment type: SINGLE co-administered:		TIARAMIDE serum	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

F_unbound

Value	Dose	Co-administered	Analyte	Population
51% OTHER GOV'T https://www.info.pmda.go.jp/go/interview/3/171911_1148001F1059_3_003_1F.pdf#page=21			TIARAMIDE plasma	Homo sapiens

Doses

Dose	Population	Adverse events
500 mg 2 times / day multiple, oral Highest studied dose Dose: 500 mg, 2 times / day Route: oral Route: multiple Dose: 500 mg, 2 times / day Sources: https://www.sciencedirect.com/science/article/abs/pii/S037860808380021X	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M Food Status: UNKNOWN Sources: https://www.sciencedirect.com/science/article/abs/pii/S037860808380021X	Disc. AE: Loss of consciousness... Other AEs: Seizures... AEs leading to discontinuation/dose reduction: Loss of consciousness Other AEs: Seizures Sources: https://www.sciencedirect.com/science/article/abs/pii/S037860808380021X
200 mg 4 times / day multiple, oral Recommended Dose: 200 mg, 4 times / day Route: oral Route: multiple Dose: 200 mg, 4 times / day Sources: https://www.sciencedirect.com/science/article/abs/pii/S037860808380021X	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://www.sciencedirect.com/science/article/abs/pii/S037860808380021X	Disc. AE: Convulsion... Other AEs: Loss of consciousness... AEs leading to discontinuation/dose reduction: Convulsion Other AEs: Loss of consciousness Sources: https://www.sciencedirect.com/science/article/abs/pii/S037860808380021X

AEs

AE	Significance	Dose	Population
Seizures		500 mg 2 times / day multiple, oral Highest studied dose Dose: 500 mg, 2 times / day Route: oral Route: multiple Dose: 500 mg, 2 times / day Sources: https://www.sciencedirect.com/science/article/abs/pii/S037860808380021X	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M Food Status: UNKNOWN Sources: https://www.sciencedirect.com/science/article/abs/pii/S037860808380021X
Loss of consciousness	Disc. AE	500 mg 2 times / day multiple, oral Highest studied dose Dose: 500 mg, 2 times / day Route: oral Route: multiple Dose: 500 mg, 2 times / day Sources: https://www.sciencedirect.com/science/article/abs/pii/S037860808380021X	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: M Food Status: UNKNOWN Sources: https://www.sciencedirect.com/science/article/abs/pii/S037860808380021X
Loss of consciousness		200 mg 4 times / day multiple, oral Recommended Dose: 200 mg, 4 times / day Route: oral Route: multiple Dose: 200 mg, 4 times / day Sources: https://www.sciencedirect.com/science/article/abs/pii/S037860808380021X	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://www.sciencedirect.com/science/article/abs/pii/S037860808380021X
Convulsion	Disc. AE	200 mg 4 times / day multiple, oral Recommended Dose: 200 mg, 4 times / day Route: oral Route: multiple Dose: 200 mg, 4 times / day Sources: https://www.sciencedirect.com/science/article/abs/pii/S037860808380021X	unhealthy, ADULT Health Status: unhealthy Age Group: ADULT Sex: F Food Status: UNKNOWN Sources: https://www.sciencedirect.com/science/article/abs/pii/S037860808380021X

PubMed

Title	Date	PubMed
Evaluation of the interaction between nonsteroidal anti-inflammatory drugs and methotrexate using human organic anion transporter 3-transfected cells.	2008-10-31	18789319
Synthesis and anti-inflammatory activity of certain piperazinylthienylpyridazine derivatives.	2007-07	17703729
Safety of selective cyclooxygenase-2 inhibitors and a basic non-steroidal anti-inflammatory drug (NSAID) in Japanese patients with NSAID-induced urticaria and/or angioedema: Comparison of meloxicam, etodolac and tiaramide.	2007-03	17291297
Strategy for structure elucidation of drug metabolites derived from protonated molecules and (MS)n fragmentation of zotepine, tiaramide and their metabolites.	2002	15618683

Patents

Sample Use Guides

In Vivo Use Guide

The recommended dose is 1 tablet (100 mg) once daily. In patients with acute upper respiratory tract inflammation the dose may be increased up to 3 tablets.

Route of Administration: Oral

In Vitro Use Guide

Tiaramide in 10(-4) and 10(-5)M inhibited effectively the platelet aggregation caused by ADP.

Name

Type

Language

RHC 2592A

Preferred Name

English

TIARAMIDE

Official Name

English

1-PIPERAZINEETHANOL, 4-((5-CHLORO-2-OXO-3(2H)-BENZOTHIAZOLYL)ACETYL)

Common Name

English

2(3H)-BENZOTHIAZOLONE, 5-CHLORO-3-(2-(4-(2-HYDROXYETHYL)-1-PIPERAZINYL)-2-OXOETHYL)-

Systematic Name

English

TIARAMIDE [MI]

Common Name

English

Tiaramide [WHO-DD]

Common Name

English

RHC-2592A

Code

English

tiaramide [INN]

Common Name

English

TIALAMIDE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C319