MOXIFLOXACIN HYDROCHLORIDE MONOHYDRATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H24FN3O4.ClH.H2O
Molecular Weight	455.908
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MOXIFLOXACIN HYDROCHLORIDE MONOHYDRATE

Structure Search

SMILES

O.Cl.[H][C@]12CN(C[C@@]1([H])NCCC2)C3=C(OC)C4=C(C=C3F)C(=O)C(=CN4C5CC5)C(O)=O

InChI

InChIKey=SKZIMSDWAIZNDD-WJMOHVQJSA-N

InChI=1S/C21H24FN3O4.ClH.H2O/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24;;/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28);1H;1H2/t11-,16+;;/m0../s1

HIDE SMILES / InChI

Description
Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s061s062,021277s057s058lbl.pdf
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/16337789 | https://www.ncbi.nlm.nih.gov/pubmed/20516287 | https://www.ncbi.nlm.nih.gov/pubmed/25801151 | https://www.ncbi.nlm.nih.gov/pubmed/11600361

Moxifloxacin is a synthetic antibacterial agent developed by Bayer AG (initially called BAY 12-8039) for oral and intravenous administration. Moxifloxacin, a fluoroquinolone, is available as the monohydrochloride salt of 1-cyclopropyl-7-[(S,S)-2,8diazabicyclo[4.3.0]non-8-yl]-6-fluoro-8-methoxy-1,4-dihydro-4-oxo-3 quinoline carboxylic acid. Moxifloxacin is marketed worldwide (as the hydrochloride) under the brand names Avelox, Avalox, and Avalon for oral treatment. In most countries, the drug is also available in the parenteral form for intravenous infusion. Moxifloxacin is also sold in an ophthalmic solution (eye drops) under the brand names Vigamox, and Moxeza for the treatment of conjunctivitis (pink eye). Its antibacterial spectrum includes enteric Gram-(−) rods (Escherichia coli, Proteus species, Klebsiella species), Haemophilus influenzae, atypical bacteria (Mycoplasma, Chlamydia, Legionella), and Streptococcus pneumoniae, and anaerobic bacteria. It differs from earlier antibacterials of the fluoroquinolone class such as levofloxacin and ciprofloxacin in having greater activity against Gram-positive bacteria and anaerobes.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Topoisomerase IV subunit A 7 Target ID: CHEMBL4088 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16337789	Inhibitor 8297		800.0 nM [IC50]
DNA gyrase subunit A 7 Target ID: CHEMBL4165 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20516287	Inhibitor 8297		9200.0 nM [IC50]

Conditions

Condition	Modality	Highest Phase	Product
Community acquired pneumonia 6 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s061s062,021277s057s058lbl.pdf	Curative	Approved 8429	AVELOX Approved Use INDICATIONS AND USAGE AVELOX is a fluoroquinolone antibacterial indicated for treating infections in adults 18 years of age and older caused by designated susceptible bacteria, in the conditions listed below: Community Acquired Pneumonia, Skin and Skin Structure Infections: Uncomplicated and Complicated, Complicated Intra-Abdominal Infections, Plague, Acute Bacterial Sinusitis, Acute Bacterial Exacerbation of Chronic Bronchitis, To reduce the development of drug-resistant bacteria and maintain the effectiveness of AVELOX and other antibacterial drugs. AVELOX should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. Launch Date 1999
Plague 14 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s061s062,021277s057s058lbl.pdf	Curative	Approved 8429	AVELOX Approved Use INDICATIONS AND USAGE AVELOX is a fluoroquinolone antibacterial indicated for treating infections in adults 18 years of age and older caused by designated susceptible bacteria, in the conditions listed below: Community Acquired Pneumonia, Skin and Skin Structure Infections: Uncomplicated and Complicated, Complicated Intra-Abdominal Infections, Plague, Acute Bacterial Sinusitis, Acute Bacterial Exacerbation of Chronic Bronchitis, To reduce the development of drug-resistant bacteria and maintain the effectiveness of AVELOX and other antibacterial drugs. AVELOX should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. Launch Date 1999
Acute bacterial sinusitis 26 Sources: http://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s061s062,021277s057s058lbl.pdf	Curative	Approved 8429	AVELOX Approved Use INDICATIONS AND USAGE AVELOX is a fluoroquinolone antibacterial indicated for treating infections in adults 18 years of age and older caused by designated susceptible bacteria, in the conditions listed below: Community Acquired Pneumonia, Skin and Skin Structure Infections: Uncomplicated and Complicated, Complicated Intra-Abdominal Infections, Plague, Acute Bacterial Sinusitis, Acute Bacterial Exacerbation of Chronic Bronchitis, To reduce the development of drug-resistant bacteria and maintain the effectiveness of AVELOX and other antibacterial drugs. AVELOX should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. Launch Date 1999

C_max

Value	Dose	Analyte	Population
3.1 mg/L DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf	400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered:	MOXIFLOXACIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
4.2 mg/L DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf	400 mg 1 times / day multiple, intravenous dose: 400 mg route of administration: Intravenous experiment type: MULTIPLE co-administered:	MOXIFLOXACIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
3.9 mg/L DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf	400 mg single, intravenous dose: 400 mg route of administration: Intravenous experiment type: SINGLE co-administered:	MOXIFLOXACIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
4.5 mg/L DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf	400 mg 1 times / day multiple, oral dose: 400 mg route of administration: Oral experiment type: MULTIPLE co-administered:	MOXIFLOXACIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
443.07 ng/ml Clinical Trial https://clinicaltrials.gov/ct2/show/NCT01296191	1 drop 4 times / day multiple, ocular dose: 1 drop route of administration: ocular experiment type: multiple co-administered:	MOXIFLOXACIN aqueous humor	Homo sapiens population: unhealthy age: sex: food status:

AUC

Value	Dose	Analyte	Population
36.1 mg × h/L DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf	400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered:	MOXIFLOXACIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
38 mg × h/L DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf	400 mg 1 times / day multiple, intravenous dose: 400 mg route of administration: Intravenous experiment type: MULTIPLE co-administered:	MOXIFLOXACIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
39.3 mg × h/L DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf	400 mg single, intravenous dose: 400 mg route of administration: Intravenous experiment type: SINGLE co-administered:	MOXIFLOXACIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
48 mg × h/L DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf	400 mg 1 times / day multiple, oral dose: 400 mg route of administration: Oral experiment type: MULTIPLE co-administered:	MOXIFLOXACIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
13.55 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf	400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered:	MOXIFLOXACIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
14.8 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf	400 mg 1 times / day multiple, intravenous dose: 400 mg route of administration: Intravenous experiment type: MULTIPLE co-administered:	MOXIFLOXACIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN
11.8 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf	400 mg single, intravenous dose: 400 mg route of administration: Intravenous experiment type: SINGLE co-administered:	MOXIFLOXACIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
12.7 h DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf	400 mg 1 times / day multiple, oral dose: 400 mg route of administration: Oral experiment type: MULTIPLE co-administered:	MOXIFLOXACIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

F_unbound

Value	Dose	Co-administered	Analyte	Population
60% DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf	400 mg single, oral dose: 400 mg route of administration: Oral experiment type: SINGLE co-administered:		MOXIFLOXACIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: UNKNOWN food status: UNKNOWN
60% DRUG LABEL https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf	400 mg single, intravenous dose: 400 mg route of administration: Intravenous experiment type: SINGLE co-administered:		MOXIFLOXACIN plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

Doses

Dose	Population	Adverse events
600 mg 1 times / day multiple, oral Higher than recommended Dose: 600 mg, 1 times / day Route: oral Route: multiple Dose: 600 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/11352436 Page: p.5	healthy, 30±7 n = 7 Health Status: healthy Age Group: 30±7 Sex: M Population Size: 7 Sources: https://pubmed.ncbi.nlm.nih.gov/11352436 Page: p.5	Sources: https://pubmed.ncbi.nlm.nih.gov/11352436 Page: p.5
800 mg single, oral Highest studied dose Dose: 800 mg Route: oral Route: single Dose: 800 mg Sources: https://pubmed.ncbi.nlm.nih.gov/9687407 Page: p.2062	healthy, 33.6 n = 8 Health Status: healthy Age Group: 33.6 Sex: M Population Size: 8 Sources: https://pubmed.ncbi.nlm.nih.gov/9687407 Page: p.2062	Sources: https://pubmed.ncbi.nlm.nih.gov/9687407 Page: p.2062
400 mg 1 times / day multiple, intravenous Recommended Dose: 400 mg, 1 times / day Route: intravenous Route: multiple Dose: 400 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.8.9	unhealthy, 50 Health Status: unhealthy Condition: Bacterial infections Age Group: 50 Sex: M+F Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.8.9	Disc. AE: Rash... AEs leading to discontinuation/dose reduction: Rash Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.8.9
400 mg 1 times / day multiple, oral Recommended Dose: 400 mg, 1 times / day Route: oral Route: multiple Dose: 400 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.8.9	unhealthy, 50 Health Status: unhealthy Condition: Bacterial infections Age Group: 50 Sex: M+F Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.8.9	Disc. AE: Nausea, Diarrhea... AEs leading to discontinuation/dose reduction: Nausea (>0.3) Diarrhea (>0.3) Dizziness (>0.3) Vomiting (>0.3) Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.8.9
800 mg 1 times / day multiple, oral Highest studied dose Dose: 800 mg, 1 times / day Route: oral Route: multiple Dose: 800 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/23343427 Page: p.7	unhealthy, 57.8 n = 5 Health Status: unhealthy Condition: Chronic bronchitis Age Group: 57.8 Sex: M+F Population Size: 5 Sources: https://pubmed.ncbi.nlm.nih.gov/23343427 Page: p.7	Sources: https://pubmed.ncbi.nlm.nih.gov/23343427 Page: p.7
400 mg 1 times / day multiple, oral\|intravenous Recommended Dose: 400 mg, 1 times / day Route: oral\|intravenous Route: multiple Dose: 400 mg, 1 times / day Co-administed with:: Linezolid, IV(600 mg q12h) Sources: https://pubmed.ncbi.nlm.nih.gov/30722059 Page: p.1863	unhealthy, 59.6 n = 273 Health Status: unhealthy Condition: Community-acquired bacterial pneumonia Age Group: 59.6 Sex: M+F Population Size: 273 Sources: https://pubmed.ncbi.nlm.nih.gov/30722059 Page: p.1863	Disc. AE: Erythema, QT interval prolonged... AEs leading to discontinuation/dose reduction: Erythema (0.37%) QT interval prolonged (1%) Angioedema (serious, 0.37%) Sources: https://pubmed.ncbi.nlm.nih.gov/30722059 Page: p.1863
400 mg 1 times / day multiple, oral\|intravenous Recommended Dose: 400 mg, 1 times / day Route: oral\|intravenous Route: multiple Dose: 400 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Bacterial infections Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.1	Disc. AE: Tendinitis, Tendon rupture... AEs leading to discontinuation/dose reduction: Tendinitis Tendon rupture Peripheral neuropathy Central nervous system disorder NOS Myasthenia gravis Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.1

AEs

AE	Significance	Dose	Population
Rash	Disc. AE	400 mg 1 times / day multiple, intravenous Recommended Dose: 400 mg, 1 times / day Route: intravenous Route: multiple Dose: 400 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.8.9	unhealthy, 50 Health Status: unhealthy Condition: Bacterial infections Age Group: 50 Sex: M+F Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.8.9
Diarrhea	>0.3 Disc. AE	400 mg 1 times / day multiple, oral Recommended Dose: 400 mg, 1 times / day Route: oral Route: multiple Dose: 400 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.8.9	unhealthy, 50 Health Status: unhealthy Condition: Bacterial infections Age Group: 50 Sex: M+F Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.8.9
Dizziness	>0.3 Disc. AE	400 mg 1 times / day multiple, oral Recommended Dose: 400 mg, 1 times / day Route: oral Route: multiple Dose: 400 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.8.9	unhealthy, 50 Health Status: unhealthy Condition: Bacterial infections Age Group: 50 Sex: M+F Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.8.9
Nausea	>0.3 Disc. AE	400 mg 1 times / day multiple, oral Recommended Dose: 400 mg, 1 times / day Route: oral Route: multiple Dose: 400 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.8.9	unhealthy, 50 Health Status: unhealthy Condition: Bacterial infections Age Group: 50 Sex: M+F Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.8.9
Vomiting	>0.3 Disc. AE	400 mg 1 times / day multiple, oral Recommended Dose: 400 mg, 1 times / day Route: oral Route: multiple Dose: 400 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.8.9	unhealthy, 50 Health Status: unhealthy Condition: Bacterial infections Age Group: 50 Sex: M+F Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.8.9
Erythema	0.37% Disc. AE	400 mg 1 times / day multiple, oral\|intravenous Recommended Dose: 400 mg, 1 times / day Route: oral\|intravenous Route: multiple Dose: 400 mg, 1 times / day Co-administed with:: Linezolid, IV(600 mg q12h) Sources: https://pubmed.ncbi.nlm.nih.gov/30722059 Page: p.1863	unhealthy, 59.6 n = 273 Health Status: unhealthy Condition: Community-acquired bacterial pneumonia Age Group: 59.6 Sex: M+F Population Size: 273 Sources: https://pubmed.ncbi.nlm.nih.gov/30722059 Page: p.1863
QT interval prolonged	1% Disc. AE	400 mg 1 times / day multiple, oral\|intravenous Recommended Dose: 400 mg, 1 times / day Route: oral\|intravenous Route: multiple Dose: 400 mg, 1 times / day Co-administed with:: Linezolid, IV(600 mg q12h) Sources: https://pubmed.ncbi.nlm.nih.gov/30722059 Page: p.1863	unhealthy, 59.6 n = 273 Health Status: unhealthy Condition: Community-acquired bacterial pneumonia Age Group: 59.6 Sex: M+F Population Size: 273 Sources: https://pubmed.ncbi.nlm.nih.gov/30722059 Page: p.1863
Angioedema	serious, 0.37% Disc. AE	400 mg 1 times / day multiple, oral\|intravenous Recommended Dose: 400 mg, 1 times / day Route: oral\|intravenous Route: multiple Dose: 400 mg, 1 times / day Co-administed with:: Linezolid, IV(600 mg q12h) Sources: https://pubmed.ncbi.nlm.nih.gov/30722059 Page: p.1863	unhealthy, 59.6 n = 273 Health Status: unhealthy Condition: Community-acquired bacterial pneumonia Age Group: 59.6 Sex: M+F Population Size: 273 Sources: https://pubmed.ncbi.nlm.nih.gov/30722059 Page: p.1863
Central nervous system disorder NOS	Disc. AE	400 mg 1 times / day multiple, oral\|intravenous Recommended Dose: 400 mg, 1 times / day Route: oral\|intravenous Route: multiple Dose: 400 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Bacterial infections Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.1
Myasthenia gravis	Disc. AE	400 mg 1 times / day multiple, oral\|intravenous Recommended Dose: 400 mg, 1 times / day Route: oral\|intravenous Route: multiple Dose: 400 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Bacterial infections Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.1
Peripheral neuropathy	Disc. AE	400 mg 1 times / day multiple, oral\|intravenous Recommended Dose: 400 mg, 1 times / day Route: oral\|intravenous Route: multiple Dose: 400 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Bacterial infections Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.1
Tendinitis	Disc. AE	400 mg 1 times / day multiple, oral\|intravenous Recommended Dose: 400 mg, 1 times / day Route: oral\|intravenous Route: multiple Dose: 400 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Bacterial infections Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.1
Tendon rupture	Disc. AE	400 mg 1 times / day multiple, oral\|intravenous Recommended Dose: 400 mg, 1 times / day Route: oral\|intravenous Route: multiple Dose: 400 mg, 1 times / day Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.1	unhealthy Health Status: unhealthy Condition: Bacterial infections Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021085s063lbl.pdf Page: p.1

Sourcing

Vendor/Aggregator	ID	URL
ChEBI	CHEBI:63611	https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:63611
MolPort	MolPort-006-167-494	https://www.molport.com/shop/molecule-link/MolPort-006-167-494
ZINC	ZINC000003826253	http://zinc15.docking.org/substances/ZINC000003826253
eMolecules	6843461	https://www.emolecules.com/cgi-bin/more?vid=6843461

PubMed

Title	Date	PubMed
Moxifloxacin: a review of its clinical potential in the management of community-acquired respiratory tract infections.	2000 Jan	10718103
Intracellular targets of moxifloxacin: a comparison with other fluoroquinolones.	2000 May	10797078
Prediction of quinolone activity against Mycobacterium avium by molecular topology and virtual computational screening.	2000 Oct	10991858
Evidence of different profiles of side effects and drug-drug interactions among the quinolones--the pharmacokinetic standpoint.	2001	11549786
Effect of calcium supplements on the oral bioavailability of moxifloxacin in healthy male volunteers.	2001	11352439
Treatment of Staphylococcus aureus endocarditis using moxifloxacin.	2001 Aug	11554565
Acute community-acquired pneumonia: current diagnosis and treatment.	2001 Jan	11227252
Activity of moxifloxacin by itself and in combination with ethambutol, rifabutin, and azithromycin in vitro and in vivo against Mycobacterium avium.	2001 Jan	11120969
The efficacy and safety of two oral moxifloxacin regimens compared to oral clarithromycin in the treatment of community-acquired pneumonia.	2001 Jul	11453311
A comparison of the bactericidal activity of quinolone antibiotics in a Mycobacterium fortuitum model.	2001 Jun	11393294
Pharmacodynamics of moxifloxacin, levofloxacin and sparfloxacin against Streptococcus pneumoniae.	2001 Jun	11389113
Antimicrobial activity of fluoroquinolone photodegradation products determined by parallel-line bioassay and high performance liquid chromatography.	2001 Mar	11222559
Adverse reactions to fluoroquinolones. an overview on mechanistic aspects.	2001 Mar	11172695
Moxifloxacin: clinical efficacy and safety.	2001 Mar 1	11258173
Clinical perspectives on new antimicrobials: focus on fluoroquinolones.	2001 Mar 15	11249831
Evaluation of the clinical microbiology profile of moxifloxacin.	2001 Mar 15	11249830
Profile of moxifloxacin drug interactions.	2001 Mar 15	11249829
Comparative in vitro activity of moxifloxacin by E-test against Streptococcus pyogenes.	2001 Mar 15	11249826
Penicillin-resistant streptococcus pneumoniae: review of moxifloxacin activity.	2001 Mar 15	11249825
Treatment outcomes in acute exacerbations of chronic bronchitis: comparison of macrolides and moxifloxacin from the patient perspective.	2001 Mar-Apr	11393351
Activity of moxifloxacin and twelve other antimicrobial agents against 216 clinical isolates of Streptococcus pneumoniae.	2001 Mar-Apr	11173809
The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis.	2001 May	11336111
Comparison of antimicrobial in vitro activities against Streptococcus pneumoniae independent of MIC susceptibility breakpoints using MIC frequency distribution curves, scattergrams and linear regression analyses.	2001 Nov	11679549
Pharmacokinetics and pharmacodynamics of fluoroquinolones.	2001 Oct	11642690
In vitro activity of moxifloxacin against common clinical bacterial isolates in Taiwan.	2001 Sep	11605808
The efficacy of moxifloxacin in acute exacerbations of chronic bronchitis: a Spanish physician and patient experience.	2001 Sep	11594251

Patents

Sample Use Guides

In Vivo Use Guide

The dose of AVELOX is 400 mg (orally or as an intravenous infusion) once every 24 hours. The duration of therapy depends on the type of infection (5--21 days).

Route of Administration: Oral

In Vitro Use Guide

Phagocytosed bacteria were divided into four aliquots with different concentrations of the drug (0, 0.1, 1 and 10 MIC). At baseline and after 1, 2 and 4 h incubation, the number of viable bacteria was determined by a subculture technique. Moxifloxacin was active against all tested staphylococci with MICs of 0.063–2 mg/L.

Name

Type

Language

MOXIFLOXACIN HYDROCHLORIDE MONOHYDRATE

Common Name

English

7-((4AS,7AS)-OCTAHYDRO-1H-PYRROLO(3,4-B)PYRIDIN-6-YL)-1-CYCLOPROPYL-6-FLUORO-8-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID HYDRATE HYDROCHLORIDE

Common Name

English

MOXIFLOXACIN HYDROCHLORIDE [IP]

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID1049063