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Details

Stereochemistry ACHIRAL
Molecular Formula 2C2H4NO2.Mn
Molecular Weight 203.0554
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MANGANESE GLYCINATE

SMILES

[Mn++].NCC([O-])=O.NCC([O-])=O

InChI

InChIKey=JNMKPXXKHWQWFB-UHFFFAOYSA-L
InChI=1S/2C2H5NO2.Mn/c2*3-1-2(4)5;/h2*1,3H2,(H,4,5);/q;;+2/p-2

HIDE SMILES / InChI
MANGANESE GLYCINATE is composed of trace mineral manganese and an amino acid, glycine. It is easily absorbable. It helps the body in a variety of ways including formation of clotting factors, connective tissue sex hormones and bones. It helps in the absorption of calcium and metabolism of carbohydrate as well as fat. It plays an important role for normal nerve and brain function. Moreover, it is a component of the enzyme, superoxide dismutase which helps fighting free radicals. Decreased manganese level can cause infertility, seizures, weakness and bone malformation. Manganese Glycinate (Mn(glycinate)2) has application as a contrast enhancement agent for magnetic resonance imaging in the heart. Toxicity, which is primarily due to the action of manganese as a calcium channel blocker with effects on muscle electrophysiology and contractility, has limited the use of manganese salts as paramagnetic contrast agents. Mn(glycinate)2 exerts its negative inotropic effect, at least partially, by interfering with the function of the L-type Ca channels at high concentrations.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Unknown

Approved Use

Unknown
Primary
Chelated Manganese Tablets

Approved Use

SUGGESTED USE: As a dietary supplement
PubMed

PubMed

TitleDatePubMed
Effect of manganese (II) bis(glycinate)dichloride on Ca2+ channel function in cultured chick atrial cells.
1991
Patents

Sample Use Guides

As a dietary supplement for adults, take one tablet (8 mg Manganese as manganese glycinate amino acid chelate) daily, preferably with a meal or as directed by a healthcare practitioner.
Route of Administration: Oral
In Vitro Use Guide
Manganese Glycinate (Mn(glycinate)2) decreased amplitude of contraction in chick atrial cells from embryos 14 days in ovo with complete inhibition of beating at 1 mM and half-maximal effect at 0.1 mM. Under control conditions, Bay K 8644, a Ca channel activator increased amplitude of contraction by 86% with a half maximal effect at 3.2 x 10(-7) M. In the presence of 0.025 mM Mn(glycinate)2, a concentration which had no effect on the amplitude of contraction, the maximum response to Bay K 8644 was decreased to 31%. Mn(glycinate)2 had no effect on the EC50 for the response to Bay K 8644, 1.7 +/- 0.1 x 10(-9) M (S.E.M., n = 4) in control cells compared to 2.2 +/- 0.4 x 10(-9) M (S.E.M., n = 4) in cells incubated with Mn(glycinate)2.
Name Type Language
MANGANESE GLYCINATE
WHO-DD  
Systematic Name English
NSC-81420
Code English
MANGANESE GLYCINATE [INCI]
Common Name English
Manganese glycinate [WHO-DD]
Common Name English
BIS(GLYCINATO)MANGANESE
Common Name English
MANGANESE CHELAZOME
Common Name English
Code System Code Type Description
PUBCHEM
151440
Created by admin on Sat Dec 16 08:31:36 GMT 2023 , Edited by admin on Sat Dec 16 08:31:36 GMT 2023
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EPA CompTox
DTXSID30329019
Created by admin on Sat Dec 16 08:31:36 GMT 2023 , Edited by admin on Sat Dec 16 08:31:36 GMT 2023
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FDA UNII
B49L2D4K1D
Created by admin on Sat Dec 16 08:31:36 GMT 2023 , Edited by admin on Sat Dec 16 08:31:36 GMT 2023
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CAS
14281-77-7
Created by admin on Sat Dec 16 08:31:36 GMT 2023 , Edited by admin on Sat Dec 16 08:31:36 GMT 2023
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SMS_ID
300000026975
Created by admin on Sat Dec 16 08:31:36 GMT 2023 , Edited by admin on Sat Dec 16 08:31:36 GMT 2023
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NSC
81420
Created by admin on Sat Dec 16 08:31:36 GMT 2023 , Edited by admin on Sat Dec 16 08:31:36 GMT 2023
PRIMARY