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Details

Stereochemistry ABSOLUTE
Molecular Formula C33H40N6O7
Molecular Weight 632.7067
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CASOKEFAMIDE

SMILES

C[C@@H](NC(=O)[C@@H](N)CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@H](C)C(=O)N[C@@H](CC3=CC=C(O)C=C3)C(N)=O

InChI

InChIKey=XDRHVZLDLNGKLM-FLVVDCEDSA-N
InChI=1S/C33H40N6O7/c1-19(36-32(45)26(34)16-22-8-12-24(40)13-9-22)31(44)39-28(18-21-6-4-3-5-7-21)33(46)37-20(2)30(43)38-27(29(35)42)17-23-10-14-25(41)15-11-23/h3-15,19-20,26-28,40-41H,16-18,34H2,1-2H3,(H2,35,42)(H,36,45)(H,37,46)(H,38,43)(H,39,44)/t19-,20-,26+,27+,28+/m1/s1

HIDE SMILES / InChI
Casokefamide is a synthetic peptide derived from the beta-casomorphin sequence, designed to increase the resistance to gastric proteases. . Casokefamide binds to both mu and delta-opioid receptors, while beta-casomorphins and its fragments are typical mu-opioid receptor agonists. Furthermore, casokefamide can affect gastric acid and pancreatic exocrine secretions and also gastrointestinal motility.

Approval Year

PubMed

PubMed

TitleDatePubMed
Effects of oral casokefamide on plasma levels, tolerance, and intestinal transit in man.
2000 Mar
Patents

Patents

Sample Use Guides

16.0 mg/day
Route of Administration: Oral
Name Type Language
CASOKEFAMIDE
INN  
INN  
Official Name English
casokefamide [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C67413
Created by admin on Fri Dec 15 16:28:55 GMT 2023 , Edited by admin on Fri Dec 15 16:28:55 GMT 2023
Code System Code Type Description
CAS
98815-38-4
Created by admin on Fri Dec 15 16:28:55 GMT 2023 , Edited by admin on Fri Dec 15 16:28:55 GMT 2023
PRIMARY
PUBCHEM
5464104
Created by admin on Fri Dec 15 16:28:55 GMT 2023 , Edited by admin on Fri Dec 15 16:28:55 GMT 2023
PRIMARY
WIKIPEDIA
Casokefamide
Created by admin on Fri Dec 15 16:28:55 GMT 2023 , Edited by admin on Fri Dec 15 16:28:55 GMT 2023
PRIMARY
NCI_THESAURUS
C77281
Created by admin on Fri Dec 15 16:28:55 GMT 2023 , Edited by admin on Fri Dec 15 16:28:55 GMT 2023
PRIMARY
EPA CompTox
DTXSID30243827
Created by admin on Fri Dec 15 16:28:55 GMT 2023 , Edited by admin on Fri Dec 15 16:28:55 GMT 2023
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ChEMBL
CHEMBL2106384
Created by admin on Fri Dec 15 16:28:55 GMT 2023 , Edited by admin on Fri Dec 15 16:28:55 GMT 2023
PRIMARY
MESH
C047075
Created by admin on Fri Dec 15 16:28:55 GMT 2023 , Edited by admin on Fri Dec 15 16:28:55 GMT 2023
PRIMARY
EVMPD
SUB06157MIG
Created by admin on Fri Dec 15 16:28:55 GMT 2023 , Edited by admin on Fri Dec 15 16:28:55 GMT 2023
PRIMARY
SMS_ID
100000081353
Created by admin on Fri Dec 15 16:28:55 GMT 2023 , Edited by admin on Fri Dec 15 16:28:55 GMT 2023
PRIMARY
INN
6808
Created by admin on Fri Dec 15 16:28:55 GMT 2023 , Edited by admin on Fri Dec 15 16:28:55 GMT 2023
PRIMARY
FDA UNII
B453T1E8MP
Created by admin on Fri Dec 15 16:28:55 GMT 2023 , Edited by admin on Fri Dec 15 16:28:55 GMT 2023
PRIMARY