Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C26H46O3 |
| Molecular Weight | 406.6416 |
| Optical Activity | ( + ) |
| Defined Stereocenters | 11 / 11 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC[C@@H]1[C@H](O)[C@H]2[C@@H]3CC[C@H]([C@H](C)CCCO)[C@@]3(C)CC[C@@H]2[C@@]4(C)CC[C@@H](O)C[C@@H]14
InChI
InChIKey=DQBAHTQWQZRMFH-CRPAWOMZSA-N
InChI=1S/C26H46O3/c1-5-18-22-15-17(28)10-12-26(22,4)21-11-13-25(3)19(16(2)7-6-14-27)8-9-20(25)23(21)24(18)29/h16-24,27-29H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21+,22+,23+,24+,25-,26-/m1/s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Agonism for the bile acid receptor GPBAR1 reverses liver and vascular damage in a mouse model of steatohepatitis. | 2019-02 |
|
| GPBAR1 Functions as Gatekeeper for Liver NKT Cells and provides Counterregulatory Signals in Mouse Models of Immune-Mediated Hepatitis. | 2019 |
|
| Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice. | 2017-10-20 |
|
| The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis. | 2017-07-15 |
|
| Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1. | 2015 |
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Systematic Name | English |
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AVN65GUL86
Created by
admin on Wed Apr 02 19:16:44 GMT 2025 , Edited by admin on Wed Apr 02 19:16:44 GMT 2025
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101886302
Created by
admin on Wed Apr 02 19:16:44 GMT 2025 , Edited by admin on Wed Apr 02 19:16:44 GMT 2025
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1632118-69-4
Created by
admin on Wed Apr 02 19:16:44 GMT 2025 , Edited by admin on Wed Apr 02 19:16:44 GMT 2025
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PRIMARY |
SUBSTANCE RECORD
