Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H20O11 |
| Molecular Weight | 448.3769 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@H]1O[C@@H](OC2=C(OC3=C(C2=O)C(O)=CC(O)=C3)C4=CC=C(O)C=C4)[C@H](O)[C@@H](O)[C@@H]1O
InChI
InChIKey=JPUKWEQWGBDDQB-QSOFNFLRSA-N
InChI=1S/C21H20O11/c22-7-13-15(26)17(28)18(29)21(31-13)32-20-16(27)14-11(25)5-10(24)6-12(14)30-19(20)8-1-3-9(23)4-2-8/h1-6,13,15,17-18,21-26,28-29H,7H2/t13-,15-,17+,18-,21+/m1/s1
Astragalin (kaempferol-3-O-glucoside) is extracted from many traditional herbs and medicinal plants. Astragalin extracted from persimmon and Rosa agrestis leaves has anti-atopic dermatitis and antioxidant activity. Several biological functions of astragalin have been studied, including inhibition of prostaglandin E2 production and angiotensin converting enzyme activity. It has been reported that astragalin has the inhibitory effect on NO and tumor necrosis factor (TNF)-α production in Raw 264.7 cells. Astragalin is a flavonoid with anti-inflammatory activity. It may be a promising cancer therapeutic drug and it has the potential of preventing atherosclerosis formation.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Inhibition of HIV infection by flavanoids. | 1993 Oct |
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| Inhibitory effects of Egyptian folk medicines on human immunodeficiency virus (HIV) reverse transcriptase. | 1995 Apr |
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| The anti-HIV activity and mechanisms of action of pure compounds isolated from Rosa damascena. | 1996 Dec 4 |
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| Evaluation of the antiviral activity of kaempferol and its glycosides against human cytomegalovirus. | 2000 May |
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| Proposed active constituents of Dipladenia martiana. | 2001 Dec |
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| Simultaneous determination of seven compounds in snow lotus herb using high-performance liquid chromatography. | 2003 May-Jun |
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| [HPLC investigation of antioxidant components in Solidago herba]. | 2004 |
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| Depsides from the petals of Papaver rhoeas. | 2004 Apr |
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| Glycosides from Grewia damine and Filicium decipiens. | 2004 Dec |
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| [The preliminary studies on antioxidation of three kinds of flavoniods from Litsea coreana]. | 2004 Feb |
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| [Applications of two-dimensional liquid chromatography coupled to mass spectrometry for the separation and identification of compounds in ginkgo biloba extracts]. | 2005 Jan |
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| [Studies on chemical constituents from flowers of Apocynum venetum]. | 2005 Sep |
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| [Studies on chemical constituents of cytotoxic fraction from leaves of Elaeagnus pungens]. | 2006 Mar |
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| Separation and determination of the effective components in the alabastrum of Edgeworthia chrysantha Lindl. by micellar electrokinetic capillary chromatography. | 2006 Mar 18 |
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| A new amide from Thyrocarpus glochidiatus. | 2006 Oct |
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| Constituents from the leaves of Phellodendron amurense and their antioxidant activity. | 2006 Sep |
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| Hepatoprotective activity of Schouwia thebica webb. | 2006 Sep 1 |
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| [Chemical study on aerial parts of Ligusticum chuanxiong]. | 2007 Jul |
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| [Studies on chemical constituents from leaves of Sapium sebiferum]. | 2007 Jun |
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| Anti-stress constituents of Evolvulus alsinoides: an ayurvedic crude drug. | 2007 May |
|
| The anti-thrombotic active constituents from Centella asiatica. | 2007 May |
|
| Isolation of 5-hydroxypyrrolidin-2-one and other constituents from the young fronds of Pteridium aquilinum. | 2008 Jul |
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| Soil quality effects on Chenopodium album flavonoid content and antioxidant potential. | 2008 Jul 9 |
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| Pharmacological basis for use of Pistacia integerrima leaves in hyperuricemia and gout. | 2008 May 22 |
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| A new fungicidal lactone from Xylocarpus granatum (Meliaceae). | 2009 |
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| [Studies on chemical constituents from leaves of Cassia alata]. | 2009 Apr |
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| Biological activity of a phloroglucinol glucoside derivative from Conyza aegyptiaca. | 2009 Jul-Aug |
|
| [Chemical constituents of Viola tianshanica]. | 2009 Nov |
|
| [Chemical constituents of flowers from Polygonum orientale]. | 2009 Oct |
|
| Cucullamide, a new putrescine bisamide from Amoora cucullata. | 2010 Aug |
|
| [Flavonoids of Lysimachia paridiformis var. stenophylla]. | 2010 Jul |
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| [Chemical constituents of Laggera pterodonta]. | 2010 Mar |
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| [Chemical constituents from Excoecaria acerifclia and their bioactivites]. | 2010 May |
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| Preparative isolation and purification of four flavonoids from the petals of Nelumbo nucifera by high-speed counter-current chromatography. | 2010 May-Jun |
|
| Inhibitory effect of astragalin on expression of lipopolysaccharide-induced inflammatory mediators through NF-κB in macrophages. | 2011 Dec |
Patents
Sample Use Guides
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APM8UQ3Z9O
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5282102
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Astragalin
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DTXSID801017739
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480-10-4
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30200
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SUBSTANCE RECORD
