Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C30H48O4 |
| Molecular Weight | 472.6997 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 11 / 11 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)C[C@@H](O)[C@H](O)C2(C)C
InChI
InChIKey=HFGSQOYIOKBQOW-ZSDYHTTISA-N
InChI=1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
DescriptionCurator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/26926180 | https://www.ncbi.nlm.nih.gov/pubmed/24260055 | https://www.ncbi.nlm.nih.gov/pubmed/25978354
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/26926180 | https://www.ncbi.nlm.nih.gov/pubmed/24260055 | https://www.ncbi.nlm.nih.gov/pubmed/25978354
Corosolic acid is a pentacyclic triterpene acid isolated from Lagerstroemia speciosa. It inhibits STAT3 and VEGFR2 signaling and has cytotoxic effect on a number of tumor cell lines. Corosolic acid has demonstrated anti-diabetic effect in vivo, probably due to facilitation of GLUT4 translocation or AMPK activation.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Ursolic acid and its natural derivative corosolic acid suppress the proliferation of APC-mutated colon cancer cells through promotion of β-catenin degradation. | 2014 May |
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| Blockade of store-operated calcium entry alleviates ethanol-induced hepatotoxicity via inhibiting apoptosis. | 2015 Aug 15 |
Patents
Sample Use Guides
Corosolic acid (0.4, 2, 10 mg/kg) was dissolved in 20 ml of distilled water was administered orally to KK-Ay strain male mice.
Route of Administration:
Oral
In Vitro Use Guide
Curator's Comment: See https://www.ncbi.nlm.nih.gov/pubmed/25978354 for VEGFR2 inhibition and related cytotoxicity experiments.
U373 cells were cultured in a 96-well plate in quadruplicate before treatment. The cells were then cultured in the presence of corosolic acid. For analysis of cytotoxic activity, the amount of lactase dehydrogenase (LDH) released into the culture supernatant was calculated by means of the LDH release assay. Corosolic acid is cytotoxic in concentration range of around 50 uM
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DSLD |
3391 (Number of products:8)
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DTXSID70904142
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Corosolic acid
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4547-24-4
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SUB26449
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1148737
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100000089654
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6918774
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AMX2I57A98
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SUBSTANCE RECORD
