Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C30H48O4 |
| Molecular Weight | 472.6997 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 11 / 11 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@]3(C)[C@]([H])(CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@]5(CC[C@@]34C)C(O)=O)[C@@]1(C)C[C@@H](O)[C@H](O)C2(C)C
InChI
InChIKey=HFGSQOYIOKBQOW-ZSDYHTTISA-N
InChI=1S/C30H48O4/c1-17-10-13-30(25(33)34)15-14-28(6)19(23(30)18(17)2)8-9-22-27(5)16-20(31)24(32)26(3,4)21(27)11-12-29(22,28)7/h8,17-18,20-24,31-32H,9-16H2,1-7H3,(H,33,34)/t17-,18+,20-,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1
DescriptionCurator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/26926180 | https://www.ncbi.nlm.nih.gov/pubmed/24260055 | https://www.ncbi.nlm.nih.gov/pubmed/25978354
Curator's Comment: description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/26926180 | https://www.ncbi.nlm.nih.gov/pubmed/24260055 | https://www.ncbi.nlm.nih.gov/pubmed/25978354
Corosolic acid is a pentacyclic triterpene acid isolated from Lagerstroemia speciosa. It inhibits STAT3 and VEGFR2 signaling and has cytotoxic effect on a number of tumor cell lines. Corosolic acid has demonstrated anti-diabetic effect in vivo, probably due to facilitation of GLUT4 translocation or AMPK activation.
Approval Year
Sample Use Guides
Corosolic acid (0.4, 2, 10 mg/kg) was dissolved in 20 ml of distilled water was administered orally to KK-Ay strain male mice.
Route of Administration:
Oral
In Vitro Use Guide
Curator's Comment: See https://www.ncbi.nlm.nih.gov/pubmed/25978354 for VEGFR2 inhibition and related cytotoxicity experiments.
U373 cells were cultured in a 96-well plate in quadruplicate before treatment. The cells were then cultured in the presence of corosolic acid. For analysis of cytotoxic activity, the amount of lactase dehydrogenase (LDH) released into the culture supernatant was calculated by means of the LDH release assay. Corosolic acid is cytotoxic in concentration range of around 50 uM
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
DSLD |
3391 (Number of products:8)
Created by
admin on Sat Dec 16 08:21:15 GMT 2023 , Edited by admin on Sat Dec 16 08:21:15 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
DTXSID70904142
Created by
admin on Sat Dec 16 08:21:15 GMT 2023 , Edited by admin on Sat Dec 16 08:21:15 GMT 2023
|
PRIMARY | |||
|
Corosolic acid
Created by
admin on Sat Dec 16 08:21:15 GMT 2023 , Edited by admin on Sat Dec 16 08:21:15 GMT 2023
|
PRIMARY | |||
|
4547-24-4
Created by
admin on Sat Dec 16 08:21:15 GMT 2023 , Edited by admin on Sat Dec 16 08:21:15 GMT 2023
|
PRIMARY | |||
|
SUB26449
Created by
admin on Sat Dec 16 08:21:15 GMT 2023 , Edited by admin on Sat Dec 16 08:21:15 GMT 2023
|
PRIMARY | |||
|
1148737
Created by
admin on Sat Dec 16 08:21:15 GMT 2023 , Edited by admin on Sat Dec 16 08:21:15 GMT 2023
|
PRIMARY | |||
|
100000089654
Created by
admin on Sat Dec 16 08:21:15 GMT 2023 , Edited by admin on Sat Dec 16 08:21:15 GMT 2023
|
PRIMARY | |||
|
6918774
Created by
admin on Sat Dec 16 08:21:15 GMT 2023 , Edited by admin on Sat Dec 16 08:21:15 GMT 2023
|
PRIMARY | |||
|
AMX2I57A98
Created by
admin on Sat Dec 16 08:21:15 GMT 2023 , Edited by admin on Sat Dec 16 08:21:15 GMT 2023
|
PRIMARY |
SUBSTANCE RECORD
