DICHLORISONE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H26Cl2O4
Molecular Weight	413.335
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DICHLORISONE

Structure Search

SMILES

[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](Cl)[C@@]3(Cl)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

InChIKey=CZJXBZPJABCCRQ-BULBTXNYSA-N

InChI=1S/C21H26Cl2O4/c1-18-7-5-13(25)9-12(18)3-4-15-14-6-8-20(27,17(26)11-24)19(14,2)10-16(22)21(15,18)23/h5,7,9,14-16,24,27H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.drugs.com/international/dichlorisone.html | https://www.ncbi.nlm.nih.gov/pubmed/13742295

DICHLORISONE is a synthetic corticosteroid used topically for its glucocorticoid activity in the treatment of various skin disorders.

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Glucocorticoid receptor 172 Target ID: CHEMBL2034 Sources: https://www.genome.jp/dbget-bin/www_bget?dr:D07814\|https://patents.google.com/patent/WO1996035426A1	Agonist 2678

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Skin Disease 1 Sources: https://www.drugs.com/international/dichlorisone.html https://www.ncbi.nlm.nih.gov/pubmed/13742295

PubMed

PubMed

Title	Date	PubMed
Dichlorisone: a "topical" steroid.	1960 Oct	13742295

Name

Type

Language

DICHLORISONE

Official Name

English

9.ALPHA.,11.BETA.-DICHLORO-17.ALPHA.,21-DIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE

Systematic Name

English

DICHLORISONE [MI]

Common Name

English

dichlorisone [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521

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Code System Code Type Description

PUBCHEM

20054892

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ChEMBL

CHEMBL1385514

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MERCK INDEX

m4327

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Merck Index

EPA CompTox

DTXSID10220353

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FDA UNII

AMW2MRV3OT

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CAS

7008-26-6

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NCI_THESAURUS

C77002

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INN

938

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ECHA (EC/EINECS)

230-283-8

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DRUG CENTRAL

3139

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WIKIPEDIA

Dichlorisone

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EVMPD

SUB07083MIG

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SMS_ID

100000082912

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ACTIVE MOIETY


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