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Details

Stereochemistry RACEMIC
Molecular Formula C12H17NO3.ClH
Molecular Weight 259.729
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NORBUDRINE HYDROCHLORIDE

SMILES

Cl.OC(CNC1CCC1)C2=CC=C(O)C(O)=C2

InChI

InChIKey=RNPLBRHKMNOUMV-UHFFFAOYSA-N
InChI=1S/C12H17NO3.ClH/c14-10-5-4-8(6-11(10)15)12(16)7-13-9-2-1-3-9;/h4-6,9,12-16H,1-3,7H2;1H

HIDE SMILES / InChI
Norbudrine (KWD2109) is a sympathomimetic drug. It is an active bronchospasmolytic agent. KWD2109 shows an in vitro bronchospasmolytic acitivity which is about 14 times better than that of KWD2025. In the in vivo tests or guinea pig bronchospasmolytic activity KWD2109 has an effect which is about 3 times that of KWD2025 after intraperitoneal and oral administration

Approval Year

Sample Use Guides

The compound Norbudrine (KWD2109) and KWD2025 have been compared in preventing bronchospasm induced by histamine aerosol in guinea pigs. The drug was injected intraperitoneally 15 minutes or administered orally 30 minutes before histamine treatment. To study the duration of the effect, 2 mg/kg was administered orally to intact guinea pigs at different time intervals before the histamine treatment.
Route of Administration: Other
Name Type Language
NORBUDRINE HYDROCHLORIDE
Common Name English
BENZYL ALCOHOL, .ALPHA.-((CYCLOBUTYLAMINO)METHYL)-3,4-DIHYDROXY-, HYDROCHLORIDE
Systematic Name English
RD 9338
Code English
RD-9338
Code English
1,2-BENZENEDIOL, 4-(2-(CYCLOBUTYLAMINO)-1-HYDROXYETHYL)-, HYDROCHLORIDE (1:1)
Systematic Name English
KWD 2109
Code English
KWD-2109
Code English
Classification Tree Code System Code
NCI_THESAURUS C48149
Created by admin on Fri Dec 15 18:02:25 GMT 2023 , Edited by admin on Fri Dec 15 18:02:25 GMT 2023
Code System Code Type Description
PUBCHEM
71586965
Created by admin on Fri Dec 15 18:02:25 GMT 2023 , Edited by admin on Fri Dec 15 18:02:25 GMT 2023
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NCI_THESAURUS
C99671
Created by admin on Fri Dec 15 18:02:25 GMT 2023 , Edited by admin on Fri Dec 15 18:02:25 GMT 2023
PRIMARY
FDA UNII
AML6U3OT9A
Created by admin on Fri Dec 15 18:02:25 GMT 2023 , Edited by admin on Fri Dec 15 18:02:25 GMT 2023
PRIMARY
CAS
13329-35-6
Created by admin on Fri Dec 15 18:02:25 GMT 2023 , Edited by admin on Fri Dec 15 18:02:25 GMT 2023
PRIMARY