Fumaderm tablets containing ethyl fumarate are given orally. The first 3 weeks, the initial tablet is given using the following schedule: 1 tablet on the first week; 2 tablets on the second week; 3 tablets in the third week. After that, full strength tablets are used: 1 tablet on the fourth week; 2 tablets on the fifth week; 3 tablets on the sixth week; 4 tablets on the 7th week; 5 tablets on the 8th weeks and 6 tablets on the week 9.

Primary human spinal cord astrocytes were treated for 6 hours with 1, 3, or 6 ug/mL ofa mixture of ethyl fumarate salts (Ca2+, Mg2+, Zn2+). The salts induced the expression of TXNRD1, SRXN1, HMOX1, NQO1 and OSGIN1 genes.