Details
Stereochemistry | ACHIRAL |
Molecular Formula | C33H45N3O8S |
Molecular Weight | 643.791 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCOC1=CC=C2N(C(=O)[C@@]3(CC[C@@H](CC3)OCCN4CCOCC4)C2=C1)S(=O)(=O)C5=C(OC)C=C(C=C5)C(=O)NC(C)(C)C
InChI
InChIKey=QKXJWFOKVQWEDZ-VCCCEUOBSA-N
InChI=1S/C33H45N3O8S/c1-6-43-25-8-9-27-26(22-25)33(13-11-24(12-14-33)44-20-17-35-15-18-42-19-16-35)31(38)36(27)45(39,40)29-10-7-23(21-28(29)41-5)30(37)34-32(2,3)4/h7-10,21-22,24H,6,11-20H2,1-5H3,(H,34,37)/t24-,33+
Sanofi-Synthélabo has developed satavaptan (previously known as SR121463) as a non-peptidic vasopressin V2 receptor antagonist for the potential treatment for cardiovascular indications such as congestive heart failure (CHF) and hypertension. The drug reached phase II for these indications before the studies were discontinued. Satavaptan was also studied for the potential treatment of glaucoma. In addition, this drug was involved in phase III clinical trials in patients with ascites due to cirrhosis of the liver and in in patients with dilutional hyponatremia. However, the further development of the satavaptan was discontinued in 2009.
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Characterization of SR 121463A, a highly potent and selective, orally active vasopressin V2 receptor antagonist. | 1996 Dec 15 |
|
Pharmacological characterization of the human vasopressin receptor subtypes stably expressed in Chinese hamster ovary cells. | 1998 Dec |
|
Identification of residues responsible for the selective binding of peptide antagonists and agonists in the V2 vasopressin receptor. | 1998 Nov 6 |
|
Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist. | 2006 Nov |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT00359437
oral administration once daily
Route of Administration:
Oral
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Code | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C2180
Created by
admin on Fri Dec 15 16:33:00 GMT 2023 , Edited by admin on Fri Dec 15 16:33:00 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
CHEMBL2107777
Created by
admin on Fri Dec 15 16:33:00 GMT 2023 , Edited by admin on Fri Dec 15 16:33:00 GMT 2023
|
PRIMARY | |||
|
AJS8S3P31H
Created by
admin on Fri Dec 15 16:33:00 GMT 2023 , Edited by admin on Fri Dec 15 16:33:00 GMT 2023
|
PRIMARY | |||
|
SUB30895
Created by
admin on Fri Dec 15 16:33:00 GMT 2023 , Edited by admin on Fri Dec 15 16:33:00 GMT 2023
|
PRIMARY | |||
|
100000115614
Created by
admin on Fri Dec 15 16:33:00 GMT 2023 , Edited by admin on Fri Dec 15 16:33:00 GMT 2023
|
PRIMARY | |||
|
SATAVAPTAN
Created by
admin on Fri Dec 15 16:33:00 GMT 2023 , Edited by admin on Fri Dec 15 16:33:00 GMT 2023
|
PRIMARY | |||
|
185913-78-4
Created by
admin on Fri Dec 15 16:33:00 GMT 2023 , Edited by admin on Fri Dec 15 16:33:00 GMT 2023
|
PRIMARY | |||
|
158348
Created by
admin on Fri Dec 15 16:33:00 GMT 2023 , Edited by admin on Fri Dec 15 16:33:00 GMT 2023
|
PRIMARY | |||
|
8591
Created by
admin on Fri Dec 15 16:33:00 GMT 2023 , Edited by admin on Fri Dec 15 16:33:00 GMT 2023
|
PRIMARY | |||
|
DB14923
Created by
admin on Fri Dec 15 16:33:00 GMT 2023 , Edited by admin on Fri Dec 15 16:33:00 GMT 2023
|
PRIMARY | |||
|
DTXSID60870165
Created by
admin on Fri Dec 15 16:33:00 GMT 2023 , Edited by admin on Fri Dec 15 16:33:00 GMT 2023
|
PRIMARY | |||
|
C80380
Created by
admin on Fri Dec 15 16:33:00 GMT 2023 , Edited by admin on Fri Dec 15 16:33:00 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)