FURNIDIPINE

Details

Stereochemistry	MIXED
Molecular Formula	C21H24N2O7
Molecular Weight	416.4245
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC(=O)C1=C(C)NC(C)=C(C1C2=C(C=CC=C2)[N+]([O-])=O)C(=O)OCC3CCCO3

InChI

InChIKey=GGVUNNUOJDGCBK-UHFFFAOYSA-N

InChI=1S/C21H24N2O7/c1-12-17(20(24)28-3)19(15-8-4-5-9-16(15)23(26)27)18(13(2)22-12)21(25)30-11-14-7-6-10-29-14/h4-5,8-9,14,19,22H,6-7,10-11H2,1-3H3

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18656554 | https://adisinsight.springer.com/drugs/800002558

Furnidipine, a calcium channel blocker was developed as an antihypertensive agent. It participated in clinical trials for the treatment of patients with heart failure, hypertension, and ischemic heart disorders in Spain and in Switzerland. However, all these studies were discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Cardioprotective effects of an active metabolite of furnidipine in 2 models of isolated heart and on in vivo ischemia–induced and reperfusion-induced arrhythmias in rats.	2011-02	21052014
Differential effects of furnidipine and its active metabolites in rat isolated working heart.	2008-02-18	18656554
Neuronal protective effects of calcium antagonists in cerebral ischemia.	1994	7997069

Name

Type

Language

CRE-319

Preferred Name

English

FURNIDIPINE

Official Name

English

furnidipine [INN]

Common Name

English

(±)-METHYL TETRAHYDROFURFURYL,1,4-DIHYDRO-2,6-DIMETHYL-4-(O-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE

Common Name

English

CRE319

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C333