Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H11NO6P2 |
| Molecular Weight | 267.1129 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OP(O)(=O)C(CC1=NC=CC=C1)P(O)(O)=O
InChI
InChIKey=NGMZSXZBZNXBGX-UHFFFAOYSA-N
InChI=1S/C7H11NO6P2/c9-15(10,11)7(16(12,13)14)5-6-3-1-2-4-8-6/h1-4,7H,5H2,(H2,9,10,11)(H2,12,13,14)
Piridronic acid is pyridinyl bisphosphonate. It is the bone calcium metabolism regulator. Piridronic acid was used for the treatment of osteoporosis. It is the human farnesyl pyrophosphate synthase inhibitor. When expressed on an actual or anticipated clinical dose basis for osteoporosis piridronic acid may have a greater potential for inducing gastric damage than do pyridinyl bisphosphonates. Piridronic acid induced significantly more antral damage than risedronate and a greater number of lesions compared to pamidronate and risedronate.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Nonclinical model for assessing gastric effects of bisphosphonates. | 1997 Feb |
|
| Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. | 2008 Apr 10 |
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NCI_THESAURUS |
C2136
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NCI_THESAURUS |
C67439
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NCI_THESAURUS |
C443
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75755-07-6
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57637
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SUB09912MIG
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C66420
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DTXSID50226652
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6043
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CHEMBL99369
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ADD4H8T3K9
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100000081667
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
