Details
Stereochemistry | ACHIRAL |
Molecular Formula | C21H25N5O2.CH4O3S |
Molecular Weight | 475.561 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CS(O)(=O)=O.CCNC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(OC)=C4
InChI
InChIKey=HKPKBPALSLUFFM-UHFFFAOYSA-N
InChI=1S/C21H25N5O2.CH4O3S/c1-3-22-18-5-4-8-23-20(18)25-9-11-26(12-10-25)21(27)19-14-15-13-16(28-2)6-7-17(15)24-19;1-5(2,3)4/h4-8,13-14,22,24H,3,9-12H2,1-2H3;1H3,(H,2,3,4)
Atevirdine (U-87201E) is a nonnucleoside inhibitor of HIV-1 reverse transcriptase, that has been studied for the treatment of HIV infection. Atevirdine mesylate is the first-generation member of the bisheteroarylpiperazine class of nonnucleoside inhibitors, which inhibits reverse transcriptase noncompetitively by binding near the catalytic site. The safety, tolerability, and antiviral activity of atevirdine were studied in phase I/II clinical trial. Rash was the most common adverse event, with a grade 3 or 4 rash. No significant change from baseline in HIV-1 plasma RNA mean copy number was detected.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL247 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7681060 |
PubMed
Title | Date | PubMed |
---|---|---|
Selective non-nucleoside HIV-1 reverse transcriptase inhibitors. New 2,3-dihydrothiazolo[2,3-a]isoindol-5(9bH)-ones and related compounds with anti-HIV-1 activity. | 1993 Aug 20 |
|
Synthesis and evaluation of 2-pyridinone derivatives as specific HIV-1 reverse transcriptase inhibitors. 3. Pyridyl and phenyl analogs of 3-aminopyridin-2(1H)-one. | 1993 Jan 22 |
|
Anti-human immunodeficiency virus type 1 activities of novel non-nucleoside reverse transcriptase inhibitors. | 1994 Feb |
|
In-vitro selection of HIV-1 variants resistant to non-nucleoside reverse transcriptase inhibitors in monocyte-derived macrophages. | 1997 Dec |
Patents
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C97453
Created by
admin on Fri Dec 15 16:37:09 GMT 2023 , Edited by admin on Fri Dec 15 16:37:09 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
DBSALT002166
Created by
admin on Fri Dec 15 16:37:09 GMT 2023 , Edited by admin on Fri Dec 15 16:37:09 GMT 2023
|
PRIMARY | |||
|
m573
Created by
admin on Fri Dec 15 16:37:09 GMT 2023 , Edited by admin on Fri Dec 15 16:37:09 GMT 2023
|
PRIMARY | Merck Index | ||
|
A948D8673W
Created by
admin on Fri Dec 15 16:37:09 GMT 2023 , Edited by admin on Fri Dec 15 16:37:09 GMT 2023
|
PRIMARY | |||
|
CHEMBL280527
Created by
admin on Fri Dec 15 16:37:09 GMT 2023 , Edited by admin on Fri Dec 15 16:37:09 GMT 2023
|
PRIMARY | |||
|
EE-42
Created by
admin on Fri Dec 15 16:37:09 GMT 2023 , Edited by admin on Fri Dec 15 16:37:09 GMT 2023
|
PRIMARY | |||
|
DTXSID30930144
Created by
admin on Fri Dec 15 16:37:09 GMT 2023 , Edited by admin on Fri Dec 15 16:37:09 GMT 2023
|
PRIMARY | |||
|
60847
Created by
admin on Fri Dec 15 16:37:09 GMT 2023 , Edited by admin on Fri Dec 15 16:37:09 GMT 2023
|
PRIMARY | |||
|
C73148
Created by
admin on Fri Dec 15 16:37:09 GMT 2023 , Edited by admin on Fri Dec 15 16:37:09 GMT 2023
|
PRIMARY | |||
|
138540-32-6
Created by
admin on Fri Dec 15 16:37:09 GMT 2023 , Edited by admin on Fri Dec 15 16:37:09 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
SUBSTANCE RECORD