ETINTIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H16N6S
Molecular Weight	276.361
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(CSCCNC(NCC#C)=NC#N)N=CN1

InChI

InChIKey=KEDVUOWPLAHMLZ-UHFFFAOYSA-N

InChI=1S/C12H16N6S/c1-3-4-14-12(16-8-13)15-5-6-19-7-11-10(2)17-9-18-11/h1,9H,4-7H2,2H3,(H,17,18)(H2,14,15,16)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2875695 | https://www.ncbi.nlm.nih.gov/pubmed/6129316 | https://www.ncbi.nlm.nih.gov/pubmed/2859600 | https://www.ncbi.nlm.nih.gov/pubmed/6130952 | https://adisinsight.springer.com/drugs/800000609

Etintidine is a potent competitive antagonist of histamine H2-receptors. It has a low level of antiandrogenic activity. Etintidine was being investigated in the treatment of peptic ulcer, however, its development has been discontinued.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H2 receptor 46 Target ID: P25021 Gene ID: 3274.0 Gene Symbol: HRH2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/2875695 \| https://www.ncbi.nlm.nih.gov/pubmed/6129316	Antagonist 2778

PubMed

Title	Date	PubMed
Clinical pharmacology of etintidine in patients with duodenal ulcer.	1982	6130952
A comparison of some of the pharmacological properties of etintidine, a new histamine H2-receptor antagonist, with those of cimetidine, ranitidine and tiotidine.	1983 Jan	6129316
In vitro and in vivo comparisons of antiandrogenic potencies of two histamine H2-receptor antagonists, cimetidine and etintidine--HCl.	1985 Jun	2859600
Pharmacological profile of etintidine, a new histamine H2-receptor antagonist.	1986 May	2875695

Patents

Sample Use Guides

In Vivo Use Guide

100 or 300 mg

Route of Administration: Oral

Name

Type

Language

ETINTIDINE

Official Name

English

GUANIDINE, N''-CYANO-N-(2-(((5-METHYL-1H-IMIDAZOL-4-YL)METHYL)THIO)ETHYL)-N'-2-PROPYNYL-

Systematic Name

English

Etintidine [WHO-DD]

Common Name

English

2-CYANO-1-(2-(((5-METHYLIMIDAZOL-4-YL)METHYL)THIO)ETHYL)-3-(2-PROPYNYL)GUANIDINE

Systematic Name

English

etintidine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29702