Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H10N2O |
| Molecular Weight | 138.1671 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NNCC1=CC=CC(O)=C1
InChI
InChIKey=OFKWWALNMPEOSZ-UHFFFAOYSA-N
InChI=1S/C7H10N2O/c8-9-5-6-2-1-3-7(10)4-6/h1-4,9-10H,5,8H2
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Locomotor response to L-DOPA in reserpine-treated rats following central inhibition of aromatic L-amino acid decarboxylase: further evidence for non-dopaminergic actions of L-DOPA and its metabolites. | 2010-09 |
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| Direct angiotensin II type 2 receptor stimulation decreases dopamine synthesis in the rat striatum. | 2010-06 |
|
| [Neurochemical study of effects of the new anxiolytic drugs afobazol and ladasten on the synthesis and metabolism of monoamines and their metabolites in the brain structures of Wistar rat on the model of monoamine synthesis blockade induced by aromatic amino acid decarboxylase inhibitor NSD-1015]. | 2010-03 |
|
| A role for serotonin in the antidepressant activity of NG-Nitro-L-arginine, in the rat forced swimming test. | 2010-02 |
|
| Alternative splicing and extensive RNA editing of human TPH2 transcripts. | 2010-01-29 |
|
| Detection of endogenous dopamine changes in Drosophila melanogaster using fast-scan cyclic voltammetry. | 2009-11-15 |
|
| Lack of differential serotonin biosynthesis capacity in genetically selected low and high aggressive mice. | 2009-10-19 |
|
| Chronic citalopram administration causes a sustained suppression of serotonin synthesis in the mouse forebrain. | 2009-08-27 |
|
| Meal ingestion, amino acids and brain neurotransmitters: effects of dietary protein source on serotonin and catecholamine synthesis rates. | 2009-08-04 |
|
| Amphetamine-evoked rotation requires newly synthesized dopamine at 14 days but not 1 day after intranigral 6-OHDA and is consistently dissociated from sensorimotor behavior. | 2009-06-08 |
|
| Acoustic stimulation in vivo and corticotropin-releasing factor in vitro increase tryptophan hydroxylase activity in the rat caudal dorsal raphe nucleus. | 2009-05-08 |
|
| Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons. | 2009-04-30 |
|
| In vivo antagonism of the behavioral responses to L-3-,4-dihydroxyphenylalanine by L-3-,4-dihydroxyphenylalanine cyclohexyl ester in conscious rats. | 2009-03-01 |
|
| Role of aminergic (serotonin and dopamine) systems in the embryogenesis and different embryonic behaviors of the pond snail, Lymnaea stagnalis. | 2009-01 |
|
| Chronic nicotine modifies the effects of morphine on extracellular striatal dopamine and ventral tegmental GABA. | 2008-11 |
|
| Expression of functional dopaminergic phenotype in purified cultured Müller cells from vertebrate retina. | 2008-09 |
|
| Evidence for serotonin synthesis-dependent regulation of in vitro neuronal firing rates in the midbrain raphe complex. | 2008-08-20 |
|
| Effect of the beta3 adrenoceptor agonist CL 316243 on hypothalamic 5-HT synthesis and suppression of REM sleep in the rat. | 2007-08 |
|
| Dopaminergic toxicity of the herbicide atrazine in rat striatal slices. | 2007-03-22 |
|
| L-DOPA inhibits depolarization-induced [3H]GABA release in the dopamine-denervated globus pallidus of the rat: the effect is dopamine independent and mediated by D2-like receptors. | 2006-12 |
|
| Validation studies on the 5-hydroxy-L-[beta-11C]-tryptophan/PET method for probing the decarboxylase step in serotonin synthesis. | 2006-06-15 |
|
| Neuropeptide Y induced attenuation of catecholamine synthesis in the rat mesenteric arterial bed. | 2006-06 |
|
| Mechanisms of black and white stripe pattern formation in the cuticles of insect larvae. | 2006-06 |
|
| L-3,4-dihydroxyphenylalanine-induced c-Fos expression in the CNS under inhibition of central aromatic L-amino acid decarboxylase. | 2006-06 |
|
| Clozapine modulates aromatic L-amino acid decarboxylase activity in mouse striatum. | 2006-05 |
|
| Metabolic transformation plays a primary role in the psychostimulant-like discriminative-stimulus effects of selegiline [(R)-(-)-deprenyl]. | 2006-04 |
|
| Synthesis, thermodynamics stability constant and relaxation properties of neutral Gd(III) complex with derivative from diethylene triamine pentaacetic acid and p-hydroxybenzoyl hydrazine. | 2006-03 |
|
| Effects of a partial D2-like receptor agonist on striatal dopamine autoreceptor functioning in preweanling rats. | 2006-02-16 |
|
| Ethanol desensitizes cannabinoid CB1 receptors modulating monoamine synthesis in the rat brain in vivo. | 2006-01-09 |
|
| L-tyrosine contributes to (+)-3,4-methylenedioxymethamphetamine-induced serotonin depletions. | 2006-01-04 |
|
| Dopaminergic mechanisms involved in prolactin release after mifepristone and naloxone treatment during late pregnancy in the rat. | 2006 |
|
| Possibility of autocrine beta-adrenergic signaling in C2C12 myotubes. | 2005-12 |
|
| Effects of manganese on extracellular levels of dopamine in rat striatum: an analysis in vivo by brain microdialysis. | 2005-09 |
|
| Dehydroepiandrosterone sulfate and allopregnanolone directly stimulate catecholamine production via induction of tyrosine hydroxylase and secretion by affecting actin polymerization. | 2005-08 |
|
| Neuropeptide Y induced modulation of dopamine synthesis in the striatum. | 2005-07-15 |
|
| Permanent deficits in serotonergic functioning of olfactory bulbectomized rats: an in vivo microdialysis study. | 2005-05-01 |
|
| Influence of polychlorinated biphenyls and turning preference on striatal dopamine metabolism. | 2005-02-13 |
|
| Long-term prenatal hypoxia alters maturation of brain catecholaminergic systems and motor behavior in rats. | 2004-11 |
|
| Serotonin reuptake inhibitors do not prevent 5,7-dihydroxytryptamine-induced depletion of serotonin in rat brain. | 2004-05-08 |
|
| Pharmacology of a novel selective 5-hydroxytryptamine1B receptor antagonist, AR-A000002. | 2004-03 |
|
| Serotonergic and dopaminergic influence of the duration of embryogenesis and intracapsular locomotion of Lymnaea stagnalis L. | 2004 |
|
| Serotonergic depression of spinal monosynaptic transmission is mediated by 5-HT1B receptors. | 2003-12-15 |
|
| Effects of acute, repeated and chronic variable stress on in vivo tyrosine hydroxylase activity and on alpha(2)-adrenoceptor sensitivity in the rat brain. | 2003-12 |
|
| Commonly used L-amino acid decarboxylase inhibitors block monoamine oxidase activity in the rat. | 2003-03 |
|
| Evidence for involvement of 5-hydroxytryptamine(1B) autoreceptors in the enhancement of serotonin turnover in the mouse brain following repeated treatment with fluoxetine. | 2002-11-01 |
|
| Chronic hypercortisolemia inhibits dopamine synthesis and turnover in the nucleus accumbens: an in vivo microdialysis study. | 2002-09 |
|
| Failure to detect in vivo inverse agonism of the 5-HT(1B) receptor antagonist SB-224289 in 5-HT-depleted guinea-pigs. | 2002-06 |
|
| Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D(3) receptors. | 2002 |
|
| Promotion of neural cell adhesion by electrochemically generated and functionalized polymer films. | 2001-11-15 |
|
| Stress-induced increase in extracellular dopamine in striatum: role of glutamatergic action via N-methyl-D-aspartate receptors in substantia nigra. | 2001-05-18 |
Patents
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| Code System | Code | Type | Description | ||
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A27K5Q85R2
Created by
admin on Mon Mar 31 21:51:51 GMT 2025 , Edited by admin on Mon Mar 31 21:51:51 GMT 2025
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1663
Created by
admin on Mon Mar 31 21:51:51 GMT 2025 , Edited by admin on Mon Mar 31 21:51:51 GMT 2025
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637-33-2
Created by
admin on Mon Mar 31 21:51:51 GMT 2025 , Edited by admin on Mon Mar 31 21:51:51 GMT 2025
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DTXSID20213099
Created by
admin on Mon Mar 31 21:51:51 GMT 2025 , Edited by admin on Mon Mar 31 21:51:51 GMT 2025
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PRIMARY |
SUBSTANCE RECORD
