SECRETIN HUMAN

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021256s013lbl.pdf | https://www.ncbi.nlm.nih.gov/pubmed/21542831

Human secretin is a gastrointestinal peptide hormone that regulates secretions in the stomach, pancreas, and liver. Synthetic human secretin displays equivalent biological activity and properties as naturally occurring secretin. Acetate salt of synthetic secretin was marketed under the name ChiRhoStim. ChiRhoStim is indicated for the stimulation of pancreatic secretions, including bicarbonate, to aid in the diagnosis of pancreatic exocrine dysfunction, for the gastrin secretion to aid in the diagnosis of gastrinoma. ChiRhoStim is also used for the pancreatic secretions to facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic, retrograde cholangiopancreatography (ERCP). When secretin binds to secretin receptors on pancreatic duct cells it opens cystic fibrosis transmembrane conductance regulator (CFTR) channels, leading to secretion of bicarbonate-rich-pancreatic fluid.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Secretin receptor 3 Target ID: P47872 Gene ID: 6344.0 Gene Symbol: SCTR Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/21542831	Binding Agent 1064

Conditions

Condition	Modality	Targets	Highest Phase	Product
exocrine pancreas dysfunction 4 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021256s013lbl.pdf	Diagnostic		Approved 8429	ChiRhoStim Approved Use ChiRhoStim® is a secretin class hormone indicated for stimulation of pancreatic secretions, including bicarbonate, to aid in the diagnosis of exocrine pancreas dysfunction; gastrin secretion to aid in the diagnosis of gastrinoma; pancreatic secretions to facilitate the identification of the ampulla of Vater and the accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP). Launch Date 2004

PubMed

Title	Date	PubMed
Secretin receptors in normal and diseased human pancreas: marked reduction of receptor binding in ductal neoplasia.	2005 Oct	16192632
Ligand binding and activation of the secretin receptor, a prototypic family B G protein-coupled receptor.	2012 May	21542831

Sample Use Guides

In Vivo Use Guide

Stimulation of pancreatic secretions, including bicarbonate, to aid in the diagnosis of exocrine pancreas dysfunction: 0.2 mcg/kg by intravenous injection over 1 minute Stimulation of gastrin secretion to aid in diagnosis of gastrinoma:0.4 mcg/kg by intravenous injection over 1 minute Stimulation of pancreatic secretions to facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography ERCP): 0.2 mcg/kg by intravenous injection over 1 minute

Route of Administration: Intravenous

Name

Type

Language

SECRETIN HUMAN

Official Name

English

SECRETIN SYNTHETIC HUMAN [ORANGE BOOK]

Common Name

English

SECRETIN (HUMAN)

Common Name

English

SECRETIN (PORCINE), 15-L-GLUTAMIC ACID-16-GLYCINE

Common Name

English

SYNTHETIC HUMAN SECRETIN

Common Name

English

secretin human [INN]

Common Name

English

HUMAN SECRETIN

Common Name

English

SECRETIN (SWINE), 15-L-GLUTAMIC ACID-16-GLYCINE-

Common Name

English

SECRETIN SYNTHETIC HUMAN

Common Name

English

HIS-SER-ASP-GLY-THR-PHE-THR-SER-GLU-LEU-SER-ARG-LEU-ARG-GLU-GLY-ALA-ARG-LEU-GLN-ARG-LEU-LEU-GLN-GLY-LEU-VAL-NH2

Common Name

English

L-HISTIDYL- L-SERYL-L-ASPARTYL-GLYCYL-L-THREONYL-L-PHENYLALANYL-L-THREONYL-L-SERYL- L-GLUTAMYL-L-LEUCYL-L-SERYL-L-ARGINYL-L-LEUCYL-L-ARGINYL-L-GLUTAMYL-GLYCYL-L-ALANYL-L-ARGINYL-L-LEUCYL-L-GLUTAMINYL-L-ARGINYL-L-LEUCYL-L-LEUCYL-L-GLUTAMINYL-GLYCYL-L-LEUC

Common Name

English

HUMAN SECRETIN [MI]

Common Name

English

SECRETIN (PIG), 15-L-GLUTAMIC ACID-16-GLYCINE-

Systematic Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

219906