U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C24H27N3O4
Molecular Weight 421.4889
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of FENPYROXIMATE

SMILES

CN1N=C(C)C(\C=N\OCC2=CC=C(C=C2)C(=O)OC(C)(C)C)=C1OC3=CC=CC=C3

InChI

InChIKey=YYJNOYZRYGDPNH-MFKUBSTISA-N
InChI=1S/C24H27N3O4/c1-17-21(22(27(5)26-17)30-20-9-7-6-8-10-20)15-25-29-16-18-11-13-19(14-12-18)23(28)31-24(2,3)4/h6-15H,16H2,1-5H3/b25-15+

HIDE SMILES / InChI
FENPYROXIMATE is a pyrazole acaricide widely used in the prevention of acarids (mites) in fruit plant gardens. It is a potent inhibitor of the mitochondrial proton-translocating NADH-quinone oxidoreductase (complex I).

Approval Year

PubMed

PubMed

TitleDatePubMed
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
2005 Dec 30
Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress.
2008 May 7
Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.
2010 Mar 15
Activity profiles of 309 ToxCastâ„¢ chemicals evaluated across 292 biochemical targets.
2011 Mar 28
Environmental impact on vascular development predicted by high-throughput screening.
2011 Nov
Fenpyroximate binds to the interface between PSST and 49 kDa subunits in mitochondrial NADH-ubiquinone oxidoreductase.
2012 Mar 6
Population-level effects of abamectin, azadirachtin and fenpyroximate on the predatory mite Neoseiulus baraki.
2016 Oct
Acute neurotoxicity following Fenpyroximate poisoning.
2018 Dec 31
123I-FP-CIT SPECT and MRI Findings in a Patient With Parkinsonism After Fenpyroximate Intoxication.
2018 Jun
Patents
Name Type Language
FENPYROXIMATE
ISO   MI  
Common Name English
NNI-850
Code English
HOE-555-02A
Code English
TERT-BUTYL (E)-.ALPHA.-(1,3-DIMETHYL-5-PHENOXYPYRAZOL-4-YLMETHYLENEAMINOOXY)-P-TOLUATE
Common Name English
4-((((E)-((1,3-DIMETHYL-5-PHENOXY-1H-PYRAZOL-4-YL)METHYLENE)AMINO)OXY)METHYL)BENZOIC ACID 1,1-DIMETHYLETHYL ESTER
Systematic Name English
FENPYROXIMATE [ISO]
Common Name English
SEQUEL
Brand Name English
FENPYROXIMATE [MI]
Common Name English
FUJIMITE
Brand Name English
FENPYROXIMATE (Z,E)
Common Name English
FENPRYROXIMATE
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 129131
Created by admin on Fri Dec 15 18:11:39 GMT 2023 , Edited by admin on Fri Dec 15 18:11:39 GMT 2023
Code System Code Type Description
CAS
134098-61-6
Created by admin on Fri Dec 15 18:11:39 GMT 2023 , Edited by admin on Fri Dec 15 18:11:39 GMT 2023
PRIMARY
PUBCHEM
9576412
Created by admin on Fri Dec 15 18:11:39 GMT 2023 , Edited by admin on Fri Dec 15 18:11:39 GMT 2023
PRIMARY
FDA UNII
9W557V4RYA
Created by admin on Fri Dec 15 18:11:39 GMT 2023 , Edited by admin on Fri Dec 15 18:11:39 GMT 2023
PRIMARY
HSDB
7943
Created by admin on Fri Dec 15 18:11:39 GMT 2023 , Edited by admin on Fri Dec 15 18:11:39 GMT 2023
PRIMARY
MESH
C415144
Created by admin on Fri Dec 15 18:11:39 GMT 2023 , Edited by admin on Fri Dec 15 18:11:39 GMT 2023
PRIMARY
CHEBI
5011
Created by admin on Fri Dec 15 18:11:39 GMT 2023 , Edited by admin on Fri Dec 15 18:11:39 GMT 2023
PRIMARY
CAS
111812-58-9
Created by admin on Fri Dec 15 18:11:39 GMT 2023 , Edited by admin on Fri Dec 15 18:11:39 GMT 2023
NON-SPECIFIC STEREOCHEMISTRY
ALANWOOD
fenpyroximate
Created by admin on Fri Dec 15 18:11:39 GMT 2023 , Edited by admin on Fri Dec 15 18:11:39 GMT 2023
PRIMARY
MERCK INDEX
m5294
Created by admin on Fri Dec 15 18:11:39 GMT 2023 , Edited by admin on Fri Dec 15 18:11:39 GMT 2023
PRIMARY Merck Index