GUANOXAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C10H13N3O2
Molecular Weight	207.2291
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of GUANOXAN

Structure Search

SMILES

NC(=N)NCC1COC2=C(O1)C=CC=C2

InChI

InChIKey=HIUVKVDQFXDZHU-UHFFFAOYSA-N

InChI=1S/C10H13N3O2/c11-10(12)13-5-7-6-14-8-3-1-2-4-9(8)15-7/h1-4,7H,5-6H2,(H4,11,12,13)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14147778 | https://www.ncbi.nlm.nih.gov/pubmed/8095548 | https://www.ncbi.nlm.nih.gov/pubmed/14301998

Guanoxan is 2-guanidinomethylbenzo-1,4-dioxan. It acts as a blocker of alpha-2 adrenoceptors. The clinical use of this drug has been in the treatment of hypertension. Both systolic and diastolic pressures are lowered in the lying and standing positions.

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed
Dihydroergotamine: an effective treatment for postural hypotension due to antihypertensive drugs (ganglion-blocking agents excepted).	1976	135643

Sample Use Guides

In Vivo Use Guide

The drug may be given orally initially at a dose of 20 mg. daily and doubled every fourth day until an effect is obtained. Where more rapid effect is desired, a loading dose of 40 mg. may be used.

Route of Administration: Oral

Name

Type

Language

GUANOXAN

Official Name

English

Guanoxan [WHO-DD]

Common Name

English

GUANOXAN [MI]

Common Name

English

guanoxan [INN]

Common Name

English

GUANIDINE, (2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLMETHYL)-

Systematic Name

English

Classification Tree Code System Code

WHO-ATC

C02CC03

Created by admin on Fri Dec 15 17:29:42 GMT 2023 , Edited by admin on Fri Dec 15 17:29:42 GMT 2023

WHO-VATC

QC02CC03

Created by admin on Fri Dec 15 17:29:42 GMT 2023 , Edited by admin on Fri Dec 15 17:29:42 GMT 2023

Code System Code Type Description

DRUG CENTRAL

1346

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PRIMARY

ChEMBL

CHEMBL76725

Created by admin on Fri Dec 15 17:29:42 GMT 2023 , Edited by admin on Fri Dec 15 17:29:42 GMT 2023

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MESH

C073344

Created by admin on Fri Dec 15 17:29:42 GMT 2023 , Edited by admin on Fri Dec 15 17:29:42 GMT 2023

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INN

1826

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CAS

2165-19-7

Created by admin on Fri Dec 15 17:29:42 GMT 2023 , Edited by admin on Fri Dec 15 17:29:42 GMT 2023

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EVMPD

SUB07989MIG

Created by admin on Fri Dec 15 17:29:42 GMT 2023 , Edited by admin on Fri Dec 15 17:29:42 GMT 2023

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WIKIPEDIA

GUANOXAN

Created by admin on Fri Dec 15 17:29:42 GMT 2023 , Edited by admin on Fri Dec 15 17:29:42 GMT 2023

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PUBCHEM

16564

Created by admin on Fri Dec 15 17:29:42 GMT 2023 , Edited by admin on Fri Dec 15 17:29:42 GMT 2023

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MERCK INDEX

m5873

Created by admin on Fri Dec 15 17:29:42 GMT 2023 , Edited by admin on Fri Dec 15 17:29:42 GMT 2023

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Merck Index

SMS_ID

100000084476

Created by admin on Fri Dec 15 17:29:42 GMT 2023 , Edited by admin on Fri Dec 15 17:29:42 GMT 2023

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EPA CompTox

DTXSID3046166

Created by admin on Fri Dec 15 17:29:42 GMT 2023 , Edited by admin on Fri Dec 15 17:29:42 GMT 2023

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NCI_THESAURUS

C174589

Created by admin on Fri Dec 15 17:29:42 GMT 2023 , Edited by admin on Fri Dec 15 17:29:42 GMT 2023

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DRUG BANK

DB13211

Created by admin on Fri Dec 15 17:29:42 GMT 2023 , Edited by admin on Fri Dec 15 17:29:42 GMT 2023

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FDA UNII

9V0MRL0R5Y

Created by admin on Fri Dec 15 17:29:42 GMT 2023 , Edited by admin on Fri Dec 15 17:29:42 GMT 2023

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ACTIVE MOIETY


					9V0MRL0R5Y

GUANOXAN

SALT/SOLVATE (PARENT)


					N6IT80R85G

GUANOXAN SULFATE