MEBHYDROLIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H20N2
Molecular Weight	276.3755
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCC2=C(C1)C3=C(C=CC=C3)N2CC4=CC=CC=C4

InChI

InChIKey=FQQIIPAOSKSOJM-UHFFFAOYSA-N

InChI=1S/C19H20N2/c1-20-12-11-19-17(14-20)16-9-5-6-10-18(16)21(19)13-15-7-3-2-4-8-15/h2-10H,11-14H2,1H3

HIDE SMILES / InChI

Description
Sources: http://www.beximcopharma.com/images/stories/product-pdf/bexidal.pdf

Mebhydrolin (INN) or mebhydroline is a histamine H1-receptor antagonist. It is not available in the United States, but it is available in various other countries under the brand names Bexidal and Diazolin. It is used for symptomatic relief of allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Histamine H1 receptor 312 Target ID: CHEMBL231 Sources: http://www.rlsnet.ru/tn_index_id_1396.htm	Antagonist 2737

Conditions

Condition	Modality	Highest Phase	Product
Urticaria 38 Sources: http://www.beximcopharma.com/images/stories/product-pdf/bexidal.pdf	Primary	Approved 8307	Bexidal Approved Use Unknown
Allergic conjunctivitis 97 Sources: http://www.beximcopharma.com/images/stories/product-pdf/bexidal.pdf	Primary	Approved 8307	Bexidal Approved Use Unknown
Dermatitis of nutritional origin 2 Sources: http://www.beximcopharma.com/images/stories/product-pdf/bexidal.pdf	Primary	Approved 8307	Bexidal Approved Use Unknown
Vasomotor rhinitis 21 Sources: http://www.beximcopharma.com/images/stories/product-pdf/bexidal.pdf	Primary	Approved 8307	Bexidal Approved Use Unknown

PubMed

Title	Date	PubMed
Cutaneous reaction to oral antihistamine.	2003 Mar	12653725
[Indole cleavage with mebhydroline by sodium periodate--part 2. Mechanism of the dilactam formation].	2006 May	16724533
Subcorneal pustular dermatosis: 50 years on.	2008 May	18355359

Sample Use Guides

In Vivo Use Guide

Adults and children over 10 years 2-6 tablets daily Children from 5-10 years 2-4 tablets daily Children from 2-5 years 1-3 tablets daily Children up to 2 years 1-2 tablets daily Treatment should be given in several single doses daily.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

MEBHYDROLIN

Official Name

English

MEBHYDROLINE [MI]

Common Name

English

BEXIDAL

Brand Name

English

Mebhydrolin [WHO-DD]

Common Name

English

MEBHYDROLIN [MART.]

Common Name

English

MEBHYDROLINE

Common Name

English

5-BENZYL-1,3,4,5-TETRAHYDRO-2-METHYL-2H-PYRIDO(4,3-B)INDOLE

Systematic Name

English

mebhydrolin [INN]

Common Name

English

NSC-757830

Code

English

Classification Tree Code System Code

WHO-VATC

QR06AX15