Details
Stereochemistry | ACHIRAL |
Molecular Formula | C10H15N3S.2ClH |
Molecular Weight | 282.233 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.NC1=NC2=C(CCN(CC=C)CC2)S1
InChI
InChIKey=DPQAXNSOFFYKDS-UHFFFAOYSA-N
InChI=1S/C10H15N3S.2ClH/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8;;/h2H,1,3-7H2,(H2,11,12);2*1H
DescriptionCurator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/8842679
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/8842679
Talipexole is a D2 receptor agonist which was marketed in June 1996 in Japan for the treatment of Parkinson's disease. Clinical trials with talipexole in patients with Parkinson's disease demonstrated statistically significant improvements from baseline for parkinsonian symptoms including akinesia, rigidity, tremor and gait disturbances.
CNS Activity
Originator
Sources: http://adisinsight.springer.com/drugs/800001261
Curator's Comment: # Boehringer Ingelheim Pharma KG
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL217 Sources: http://www.ncbi.nlm.nih.gov/pubmed/10455328 |
5.8 null [pKi] | ||
Target ID: CHEMBL234 Sources: http://www.ncbi.nlm.nih.gov/pubmed/10455328 |
7.0 null [pKi] | ||
Target ID: CHEMBL1867 Sources: http://www.ncbi.nlm.nih.gov/pubmed/12388666 |
7.43 null [pKi] | ||
Target ID: CHEMBL1942 Sources: http://www.ncbi.nlm.nih.gov/pubmed/12388666 |
7.09 null [pKi] | ||
Target ID: CHEMBL1916 Sources: http://www.ncbi.nlm.nih.gov/pubmed/12388666 |
7.37 null [pKi] | ||
Target ID: CHEMBL219 Sources: http://www.ncbi.nlm.nih.gov/pubmed/12388666 |
6.48 null [pKi] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
|||
Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
Intranasal application of the alpha2-adrenoceptor agonist BHT-920 produces decongestion in the cat. | 2001 Nov-Dec |
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Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. | 2002 Nov |
|
Practice parameters for the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder. | 2004 May 1 |
|
Drug treatment of Parkinson's disease. | 2004 Sep |
|
Pre-junctional alpha2-adrenoceptors modulation of the nitrergic transmission in the pig urinary bladder neck. | 2007 |
|
Effect of bromocriptine on the severity of ovarian hyperstimulation syndrome and outcome in high responders undergoing assisted reproduction. | 2010 May |
|
[Dopaminergic neuroprotection and reconstruction of neural network tiara]. | 2010 Oct |
Patents
Sample Use Guides
Initially 0.2 or 0-4 mg/day, increased by 0.4 mg every week (usual maintenance dosage 1.2 to 3.6 mg/day)
Below 0.8 mg/day, once a day; 0.8 to 1.2 mg/day, twice a day; over 1.2 mg/day, 3 times a day
Route of Administration:
Oral
In Vitro Use Guide
Sources: http://www.ncbi.nlm.nih.gov/pubmed/11301060
Talipexole at low concentration (0.1-1 mM) significantly inhibited the accumulation of cytochrome c in the cytosolic fraction of human neuroblastoma SH-SY5Y cells
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36085-73-1
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104870
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100000090502
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9R6E1D8H1O
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DTXSID20189669
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SUB04670MIG
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m10441
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PRIMARY | Merck Index |
ACTIVE MOIETY
SUBSTANCE RECORD