ENVIRADENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H21N3O2S
Molecular Weight	355.454
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C\C=C(/C1=CC=CC=C1)C2=CC3=C(C=C2)N=C(N)N3S(=O)(=O)C(C)C

InChI

InChIKey=BFPYUXIFGJJYHU-AYSLTRBKSA-N

InChI=1S/C19H21N3O2S/c1-4-16(14-8-6-5-7-9-14)15-10-11-17-18(12-15)22(19(20)21-17)25(23,24)13(2)3/h4-13H,1-3H3,(H2,20,21)/b16-4+

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8540755 | https://adisinsight.springer.com/drugs/800006810

Enviradene (LY 127123) is a benzimidazole antiviral compound. It inhibited picornavirus replication and infection in vitro.

Originator

Approval Year

PubMed

Title	Date	PubMed
Inhibition of the enteroviruses that cause acute hemorrhagic conjunctivitis (AHC) by benzimidazoles; enviroxime (LY 122772) and enviradone (LY 127123).	1995-08	8540755
Liquid chromatographic analysis of enviradene, a new antiviral agent, in plasma and its application in bioavailability studies in the dog.	1985-08	4032268
Prevention of death in mice infected with coxsackievirus A16 using guanidine HCl mixed with substituted benzimidazoles.	1982-12	6299189

Sample Use Guides

In Vitro Use Guide

The 50% CPE inhibitory dose (ID50) for enviroxime and enviradene (LY 127123) against 11 EV70 and 15 CA24v isolates ranged from 0.01 to 0.3 microgram and 0.01-0.65 microgram/ml, respectively.

Name

Type

Language

LY-127123

Preferred Name

English

ENVIRADENE

Official Name

English

(E)-1-((1-METHYLETHYL)SULFONYL)-6-(1-PHENYL-1-PROPENYL)-1H-BENZIMIDAZOL-2-AMINE

Systematic Name

English

ENVIRADENE [USAN]

Common Name

English

1H-BENZIMIDAZOL-2-AMINE, 1-((1-METHYLETHYL)SULFONYL)-6-(1-PHENYL-1-PROPENYL)-, (E)-

Common Name

English

LY127123

Code

English

enviradene [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C281