EPETIRIMOD

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H15N5
Molecular Weight	241.2917
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)CN1C=NC2=C1C3=NC=CC=C3N=C2N

InChI

InChIKey=UCPMSMNKGXUFCC-UHFFFAOYSA-N

InChI=1S/C13H15N5/c1-8(2)6-18-7-16-11-12(18)10-9(17-13(11)14)4-3-5-15-10/h3-5,7-8H,6H2,1-2H3,(H2,14,17)

HIDE SMILES / InChI

Description
Sources: https://adisinsight.springer.com/drugs/800022290 | https://www.ncbi.nlm.nih.gov/pubmed/20001552

Epetirimod (S-30563 or TAK-851) is an immunostimulant. The compound is structurally related to the marketed topical imidazoquinoline drug, imiquimod, an agonist of Toll-like receptor 7. Epetirimod was under development with Takeda Pharmaceutical as a topical treatment for cervical high-risk HPV infection and cervical dysplasia. Takeda has discontinued epetirimod development as it did not meet the predefined efficacy end points in a US Phase II trial.

Originator

Approval Year

PubMed

Title	Date	PubMed
Discontinued drugs in 2008: anti-infectives.	2010 Jan	20001552

Patents

Name

Type

Language

EPETIRIMOD

Official Name

English

EPETIRIMOD [USAN]

Common Name

English

851A

Code

English

851-A

Code

English

1-(2-Methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine

Systematic Name

English

1H-IMIDAZO(4,5-C)(1,5)NAPHTHYRIDIN-4-AMINE, 1-(2-METHYLPROPYL)-

Systematic Name

English

S-30563

Code

English

epetirimod [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C308