Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff[2] and eczema. Climbazole is an antimycotic agent with a high in vitro and in vivo efficacy against P. ovale. After a 1-week washout and a 4-week treatment the clinical evaluation showed a successful reduction of dandruff under the climbazole 0.65% shampoo, skin redness and itching in 80% of the volunteers and a mild improvement in 20% of the volunteers. The cosmetic acceptability was very good by the majority. It is concluded that the formulation tested is effective in the treatment of moderate to severe dandruff. It is most commonly found as an active ingredient in OTC anti-dandruff and anti-fungal products, including shampoos, lotions and conditioners. May cause localized irritation of the skin with symptoms including redness, rashes and itching