PARGYLINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H13N
Molecular Weight	159.2276
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CN(CC#C)CC1=CC=CC=C1

InChI

InChIKey=DPWPWRLQFGFJFI-UHFFFAOYSA-N

InChI=1S/C11H13N/c1-3-9-12(2)10-11-7-5-4-6-8-11/h1,4-8H,9-10H2,2H3

HIDE SMILES / InChI

Description

Pargyline is an irreversible selective monoamine oxidase (MAO)-B inhibitor, which possesses higher selectivity to this isoform in comparison with MAO-A. It was approved under brand name eutonyl for the treatment hypertension, but then this drug was discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Monoamine oxidase B 75	Inhibitor 8,504

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 575	Primary		Approved 8,583	Eutonyl

C_max

Value	Dose	Co-administered	Analyte	Population
75 ng/mL	50 mg single, oral		PARGYLINE plasma	Homo sapiens

AUC

Value	Dose	Co-administered	Analyte	Population
272 ng × h/mL	50 mg single, oral		PARGYLINE plasma	Homo sapiens

T_1/2

Value	Dose	Co-administered	Analyte	Population
5 h	50 mg single, oral		PARGYLINE plasma	Homo sapiens

Overview

CYP3A4	CYP2C9	CYP2D6	hERG

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP2E1 1,060 CYP2B1 14 CYP1A1 132	CYP2B1 12 CYP2E1 729

Drug as perpetrator

Show entries

Target	Modality	Activity
CYP1A1 272	inhibitor 4,027	yes
CYP2B1 41	inhibitor 4,027	yes
CYP2E1 1,146	inhibitor 4,027	yes

Showing 1 to 3 of 3 entries

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Drug as victim

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Target	Modality	Activity	Metabolite	Clinical evidence
CYP2B1 12	substrate 4,014	yes
CYP2E1 729	substrate 4,014	yes

Showing 1 to 2 of 2 entries

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Sourcing

Sourcing

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Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-049611	http://www.3bsc.com/index/pro_info.php?id=87188
AA Blocks	AA0030KE	http://www.aablocks.com/goods/Goods/detail?id=AA0030KE
Aaron Chemicals	AR0031C6	http://www.aaronchem.com/306-07-0
abcr GmbH	AB125516	http://www.abcr.de/shop/en/AB125516
AbMole Bioscience	M5860	http://www.abmole.com/products/pargyline-hcl.html

Showing 1 to 5 of 54 entries

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PubMed

Show entries

Title	Date	PubMed
Selective and nonselective monoamine oxidase inhibitors: behavioral disturbances during their administration to depressed patients.	1982 May	7092487
Pargyline-induced mania in primary affective disorder: case report.	1983 Jan	6822482
The involvement of noradrenaline, 5-hydroxytryptamine and acetylcholine in imipramine-induced seizures in mice.	1993 Oct 15	8224101
The MAO-B inhibitor deprenyl, but not the MAO-A inhibitor clorgyline, potentiates the neurotoxicity of p-chloroamphetamine.	1994 Jul 11	7953696
GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice.	1994 Oct	7875556

Showing 1 to 5 of 6 entries

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Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

In Vitro Use Guide

Unknown

Show entries

Name

Type

Language

PARGYLINE [MI]

Preferred Name

English

PARGYLINE

Official Name

English

BENZENEMETHANAMINE, N-METHYL-N-2-PROPYNYL-

Systematic Name

English

pargyline [INN]

Common Name

English

Pargyline [WHO-DD]

Common Name

English

Showing 1 to 5 of 7 entries

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Classification Tree

Code System

Code

MAO inhibitors and diuretics

WHO-ATC

C02LL01

Agent Affecting Cardiovascular System

NCI_THESAURUS

C270

MAO inhibitors and diuretics

WHO-VATC

QC02LL01

Enzyme Inhibitor

NCI_THESAURUS

C667

MAO inhibitors

WHO-VATC

QC02KC01

Showing 1 to 5 of 6 entries

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Show entries

Code System

Code

Type

Description

DRUG BANK

DB01626

PRIMARY

IUPHAR

7262

PRIMARY

DRUG CENTRAL

2065

PRIMARY

EPA CompTox

DTXSID3023423

PRIMARY

CAS

555-57-7

PRIMARY

Showing 1 to 5 of 17 entries

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ACTIVE MOIETY


					9MV14S8G3E

PARGYLINE

SALT/SOLVATE (PARENT)


					W70V6I2OMY

PARGYLINE HYDROCHLORIDE

SMILES

InChI

Originator

Approval Year

Targets

Conditions

Cmax

AUC

T1/2

Overview

OverviewOther

Drug as perpetrator​

Drug as victim

Sourcing

PubMed

Patents

Sample Use Guides

C_max

T_1/2

Drug as perpetrator