Details
Stereochemistry | ACHIRAL |
Molecular Formula | C22H25NO4.H3O4P |
Molecular Weight | 465.4334 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OP(O)(O)=O.CCOC1=CC=C(CC2=C3C=C(OC)C(OC)=CC3=CC(C)=N2)C=C1OC
InChI
InChIKey=YZKZXTBSUSEYQZ-UHFFFAOYSA-N
InChI=1S/C22H25NO4.H3O4P/c1-6-27-19-8-7-15(11-20(19)24-3)10-18-17-13-22(26-5)21(25-4)12-16(17)9-14(2)23-18;1-5(2,3)4/h7-9,11-13H,6,10H2,1-5H3;(H3,1,2,3,4)
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/14824008Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/14936209 | https://www.ncbi.nlm.nih.gov/pubmed/13240796 | https://www.ncbi.nlm.nih.gov/pubmed/13092557
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14824008
Curator's Comment: description was created based on several sources, including:
https://www.ncbi.nlm.nih.gov/pubmed/14936209 | https://www.ncbi.nlm.nih.gov/pubmed/13240796 | https://www.ncbi.nlm.nih.gov/pubmed/13092557
Dimoxyline is the synthetic analogue of papaverine, Acute toxicity studies show it to be less toxic than papaverine. No analgesic action and no tolerance development in experimental animals by repeated administration. But Dimoxyline does not appear to be as potent as papaverine in comparable dosage. Dimoxyline is indicated for the treatment of patients with angina pectoris. Also, significant amount of benefit was claimed in patients with acute or chronic phlebitis, arterial thrombosis or embolism, Raynaud’s phenomena and early thromboangiitis obliterans or arteriosclerosis obliterans. Detected adverse events are: nausea or abdominal cramps.
Originator
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14824008
Curator's Comment: # Eli Lilly
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Effects of dioxyline phosphate and enteric-coated khellin on coronary artery insufficiency. | 1951 Jul |
|
Studies on the use of dioxyline phosphate in the treatment of angina pectoris. | 1952 Jul |
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Anginal relief with paveril phosphate. | 1952 May |
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Papaverine analogs. 8. Comparative actions of papaverine, ethaverine and dioxyline on the cardiovascular system. | 1960 Jul 1 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14936209
200 mg four times daily
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14824008
When the phosphate of the Dimoxyline was added to the Tyrode’s solution in which a strip of rabbit small intestine was suspended, a concentration of 1 :100,000 and 1200,000 caused a slight reduction in tone and a depression in the number of contractions per unit of time.
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NCI_THESAURUS |
C29707
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m147
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21877
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9M18MC2SIE
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CHEMBL2108950
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5667-46-9
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100000087515
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DTXSID40205234
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SUB01757MIG
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C77073
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227-126-0
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ACTIVE MOIETY
SUBSTANCE RECORD