Details
Stereochemistry | ACHIRAL |
Molecular Formula | Cr2O7 |
Molecular Weight | 215.988 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | -2 |
SHOW SMILES / InChI
SMILES
[O-][Cr](=O)(=O)O[Cr]([O-])(=O)=O
InChI
InChIKey=SOCTUWSJJQCPFX-UHFFFAOYSA-N
InChI=1S/2Cr.7O/q;;;;;;;2*-1
Sodium dichromate is an inorganic compound, containing hexavalent chromium. It is highly corrosive and is a strong oxidizing agent. Sodium dichromate is mainly used to produce other chromium compounds but is also used in drilling muds, in metal treatments, in wood preservatives, in the production of dyes and organic chemicals and as a corrosion inhibitor. Sodium dichromate primarily affects the respiratory system causing ulcerations, shortness of breath, bronchitis, pneumonia, and asthma but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity.
Approval Year
PubMed
Title | Date | PubMed |
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Effects of Cr(VI) on the expression of the oxidative stress genes in human lung cells. | 1998 Aug |
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Inhibition of protein synthesis by chromium(VI) differentially affects expression of urokinase and its receptor in human type II pneumocytes. | 1999 Aug 1 |
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Differential effects of arsenic(III) and chromium(VI) on nuclear transcription factor binding. | 1999 Jul |
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Role of p53 tumor suppressor gene in the toxicity of TCDD, endrin, naphthalene, and chromium (VI) in liver and brain tissues of mice. | 2000 Mar 15 |
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The role of hydroxyl radical as a messenger in Cr(VI)-induced p53 activation. | 2000 Sep |
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LLU-alpha, an endogenous metabolite of gamma-tocopherol, is more effective against metal nephrotoxicity in rats than gamma-tocopherol. | 2001 Jul 6 |
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Induction of apoptosis in the lung but not in the liver of rats receiving intra-tracheal instillations of chromium(VI). | 2002 Apr |
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Down-regulation of the DNA-repair endonuclease 8-oxo-guanine DNA glycosylase 1 (hOGG1) by sodium dichromate in cultured human A549 lung carcinoma cells. | 2002 Jan |
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Selective induction of gene expression in rat lung by hexavalent chromium. | 2002 Oct |
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NTP toxicity studies of sodium dichromate dihydrate (CAS No. 7789-12-0) administered in drinking water to male and female F344/N rats and B6C3F1 mice and male BALB/c and am3-C57BL/6 mice. | 2007 Jan |
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Exposure to nickel, chromium, or cadmium causes distinct changes in the gene expression patterns of a rat liver derived cell line. | 2011 |
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Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90days of exposure to hexavalent chromium in drinking water. | 2012 Feb 15 |
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Comparison of the effects of hexavalent chromium in the alimentary canal of F344 rats and B6C3F1 mice following exposure in drinking water: implications for carcinogenic modes of action. | 2012 Jan |
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Inhibitory effect of SJSZ glycoprotein (38 kDa) on expression of heat shock protein 27 and 70 in chromium (VI)-treated hepatocytes. | 2012 Jan |
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Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelia. | 2012 Jul 15 |
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Whole adult organism transcriptional profiling of acute metal exposures in male zebrafish. | 2014 Mar 10 |
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1313336
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DTXSID5074004
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24503
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33141
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DB14182
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13907-47-6
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ACTIVE MOIETY