Details
Stereochemistry | RACEMIC |
Molecular Formula | C20H23N3O4 |
Molecular Weight | 369.4143 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(CNCCNC(=O)CC1=CC=C(O)C=C1)COC2=C(C=CC=C2)C#N
InChI
InChIKey=YARKMNAWFIMDKV-UHFFFAOYSA-N
InChI=1S/C20H23N3O4/c21-12-16-3-1-2-4-19(16)27-14-18(25)13-22-9-10-23-20(26)11-15-5-7-17(24)8-6-15/h1-8,18,22,24-25H,9-11,13-14H2,(H,23,26)
Epanolol has been shown in animal models to be a selective beta-adrenoceptor partial agonist with agonist activity about 20 to 25% of that of the full agonist isoprenaline. Epanolol is a once-daily agent for the treatment of angina pectoris. The pharmacodynamic consequences in man of the degree of agonist activity possessed by the beta 1-selective partial agonist epanolol include little reductions at rest in heart rate, blood pressure, various measures of cardiac haemodynamic parameters, peripheral blood flow and renal function. On exercise there is attenuation of the heart rate and systolic blood pressure responses, with less perceived exertion than with atenolol. The lack of significant accumulation of epanolol indicates that no alteration of dose is necessary when using epanolol in elderly patients with normal renal and hepatic function.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2575977
Single daily dose - 200 mg
Route of Administration:
Oral
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29576
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WHO-ATC |
C07AB10
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WHO-VATC |
QC07AB10
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C72616
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EPANOLOL
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W-141
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SUB06558MIG
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5654
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72014
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4467
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9KGC55KP6A
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DB13757
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m162
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DTXSID90868959
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100000080243
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CHEMBL87697
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86880-51-5
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ACTIVE MOIETY