Details
Stereochemistry | ACHIRAL |
Molecular Formula | C13H16N2O2 |
Molecular Weight | 232.2783 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CCCCCC1=CC=CC2=CN=CN12
InChI
InChIKey=LIFOFTJHFFTNRV-UHFFFAOYSA-N
InChI=1S/C13H16N2O2/c16-13(17)8-3-1-2-5-11-6-4-7-12-9-14-10-15(11)12/h4,6-7,9-10H,1-3,5,8H2,(H,16,17)
Pirmagrel is the selective thromboxane synthetase inhibitor. The compound was well tolerated by all subjects without evidence of any adverse reactions. Serum thromboxane B2 levels (the stable metabolic product of thromboxane A2) were significantly reduced after administration of the compound, with the maximal effect of a 99 per cent reduction occurring at 0.5 and 1 hour after administration. Bleeding times showed a slight increase 2 hours after administration of the compound. Pirmagrel was able to completely prevent the increase in serum thromboxane B2 following allergen challenge in asthmatic patients; while it caused a very small reduction in the early response to allergen, there was no effect on the late response or on airway hyperresponsiveness. Pirmagrel was developed for the treatment of ischemic heart disorders and thrombosis. However, this development was discontinued.
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Long-term renal preservation and prevention of acute tubular necrosis by inhibition of arachidonate metabolism. | 1993 Aug |
|
Suppression of S-antigen-induced experimental autoimmune uveoretinitis in Lewis rats by oral administration with CGS-13080, a thromboxane synthetase inhibitor. | 1993 Nov |
|
Peroxide-cyclooxygenase interactions in postasphyxial changes in retinal and choroidal hemodynamics. | 1995 Jun |
|
Analysis of eicosanoid mediation of the renal functional effects of hyperchloremia. | 1997 Jul |
|
Effects of hypoxia on regulation of prostanoid production in decidual endothelial cells in normal and preeclamptic pregnancy. | 2000 Mar-Apr |
|
Critical role of endothelial nitric oxide synthase and cyclooxygenase in response of rabbit basilar artery to serotonin. | 2002 Sep |
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Code | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
NCI_THESAURUS |
C1327
Created by
admin on Fri Dec 15 15:26:15 GMT 2023 , Edited by admin on Fri Dec 15 15:26:15 GMT 2023
|
||
|
NCI_THESAURUS |
C574
Created by
admin on Fri Dec 15 15:26:15 GMT 2023 , Edited by admin on Fri Dec 15 15:26:15 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
9J5H2VA91V
Created by
admin on Fri Dec 15 15:26:15 GMT 2023 , Edited by admin on Fri Dec 15 15:26:15 GMT 2023
|
PRIMARY | |||
|
SUB09924MIG
Created by
admin on Fri Dec 15 15:26:15 GMT 2023 , Edited by admin on Fri Dec 15 15:26:15 GMT 2023
|
PRIMARY | |||
|
DTXSID80234982
Created by
admin on Fri Dec 15 15:26:15 GMT 2023 , Edited by admin on Fri Dec 15 15:26:15 GMT 2023
|
PRIMARY | |||
|
CHEMBL2104615
Created by
admin on Fri Dec 15 15:26:15 GMT 2023 , Edited by admin on Fri Dec 15 15:26:15 GMT 2023
|
PRIMARY | |||
|
55390
Created by
admin on Fri Dec 15 15:26:15 GMT 2023 , Edited by admin on Fri Dec 15 15:26:15 GMT 2023
|
PRIMARY | |||
|
C96933
Created by
admin on Fri Dec 15 15:26:15 GMT 2023 , Edited by admin on Fri Dec 15 15:26:15 GMT 2023
|
PRIMARY | |||
|
W-46
Created by
admin on Fri Dec 15 15:26:15 GMT 2023 , Edited by admin on Fri Dec 15 15:26:15 GMT 2023
|
PRIMARY | |||
|
85691-74-3
Created by
admin on Fri Dec 15 15:26:15 GMT 2023 , Edited by admin on Fri Dec 15 15:26:15 GMT 2023
|
PRIMARY | |||
|
5691
Created by
admin on Fri Dec 15 15:26:15 GMT 2023 , Edited by admin on Fri Dec 15 15:26:15 GMT 2023
|
PRIMARY | |||
|
100000081673
Created by
admin on Fri Dec 15 15:26:15 GMT 2023 , Edited by admin on Fri Dec 15 15:26:15 GMT 2023
|
PRIMARY |
ACTIVE MOIETY