U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Sb
Molecular Weight 121.76
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ANTIMONY

SMILES

[Sb]

InChI

InChIKey=OUULRIDHGPHMNQ-UHFFFAOYSA-N
InChI=1S/Sb.3H

HIDE SMILES / InChI
Antimony (Sb) is a toxic metalloid that occurs widely at trace concentrations in soil, aquatic systems, and the atmosphere. Antimony is not an abundant element but is found in small quantities in over 100 mineral species. It is most often found as antimony(III) sulfide. Antimony is used in the electronics industry to make some semiconductor devices, such as infrared detectors and diodes. It is alloyed with lead or other metals to improve their hardness and strength. A lead-antimony alloy is used in batteries. Other uses of antimony alloys include type metal (in printing presses), bullets and cable sheathing. Antimony has been in medical use against microbes and parasites as well. Antimony-based drugs have been prescribed against leishmaniasis since the parasitic transmission of the tropical disease was understood in the beginning of the 20th century. As a therapeutic, antimony has been mostly used for the treatment of leishmaniasis and schistosomiasis. The major toxic side-effects of antimonials as a result of therapy are cardiotoxicity (~9% of patients) and pancreatitis, which is seen commonly in HIV and visceral leishmaniasis co-infections.

Approval Year

PubMed

PubMed

TitleDatePubMed
Response to chemotherapy in experimental visceral leishmaniasis: T cell-dependent but interferon-gamma- and interleukin-2-independent.
1991 Mar
[Visceral leishmaniasis and multiple organ failure].
1993 Dec
Granulocyte-macrophage colony-stimulating factor in combination with pentavalent antimony for the treatment of visceral Leishmaniasis.
1994
[Interferon gamma as an immunological strategy for the treatment of human leishmaniasis].
1994
Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells.
1994 Nov 15
Interleukin 6 during active visceral leishmaniasis and after treatment.
1995 Oct
[Clinical and pathogenetic features of exposure of workers to antimonate ore].
1996
Treatment of New World cutaneous and mucosal leishmaniases.
1996 Sep-Oct
Efficacy and Tolerability of Liposomal Amphotericin B (Ambisome) in the Treatment of Visceral Leishmaniasis in Brazil.
1997 Oct
Leishmaniasis of glans penis.
1998 May
Marked elevation of myocardial trace elements in idiopathic dilated cardiomyopathy compared with secondary cardiac dysfunction.
1999 May
Mucosal leishmaniasis: quantitative nasal cytology as a marker of disease activity and indicator of healing.
2000 Jan
Interleukin-12 regulates the response to chemotherapy in experimental visceral Leishmaniasis.
2000 Nov
Leishmaniasis in Sudan. Mucosal leishmaniasis.
2001 Apr
Cutaneous leishmaniasis in an Italian woman: case report.
2001 Jun
Novel bicistronic retroviral vector expressing gamma-glutamylcysteine synthetase and the multidrug resistance protein 1 (MRP1) protects cells from MRP1-effluxed drugs and alkylating agents.
2001 Sep 20
In vitro susceptibility to pentavalent antimony in Leishmania infantum strains is not modified during in vitro or in vivo passages but is modified after host treatment with meglumine antimoniate.
2002 May 2
Functional identification of ion binding sites at the internal end of the pore in Shaker K+ channels.
2003 May 15
Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9.
2004 Sep 24
Leishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug pentostam.
2004 Sep 3
Classification of heavy-metal toxicity by human DNA microarray analysis.
2007 May 15
Characterization and distribution of the selected metals in the scalp hair of cancer patients in comparison with normal donors.
2007 Sep
Cutaneous leishmaniasis with boggy induration and simultaneous mucosal disease.
2009 Jan
A case of visceral leishmaniasis in Oltenia region (Romania).
2010
A case with two unusual findings: cutaneous leishmaniasis presenting as panniculitis and pericarditis after antimony therapy.
2010 Mar
[An adult case of visceral leishmaniasis in a province of Black-Sea region, Turkey].
2010 Oct
Monitoring of intracellular nitric oxide in leishmaniasis: its applicability in patients with visceral leishmaniasis.
2011 Jan
Solubility shift and SUMOylaltion of promyelocytic leukemia (PML) protein in response to arsenic(III) and fate of the SUMOylated PML.
2015 Sep 15
Name Type Language
ANTIMONY
MI   WHO-DD  
Systematic Name English
Antimony [WHO-DD]
Common Name English
STIBIUM METALLICUM [HPUS]
Common Name English
STIBIUM METALLICUM
HPUS  
Common Name English
SB
Code English
ANTIMONY, ELEMENTAL
HSDB  
Common Name English
STIBIUM
Systematic Name English
C.I. 77050
Code English
PREPARED METALLIC ANTIMONY
Common Name English
ANTIMONY ELEMENT
Common Name English
ANTIMONY BLACK
Common Name English
ANTIMONY, ELEMENTAL [HSDB]
Common Name English
ANTIMONY [MI]
Common Name English
METALLIC ANTIMONY
Common Name English
Classification Tree Code System Code
DSLD 3349 (Number of products:23)
Created by admin on Fri Dec 15 17:17:42 GMT 2023 , Edited by admin on Fri Dec 15 17:17:42 GMT 2023
CFR 21 CFR 862.3110
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NCI_THESAURUS C1940
Created by admin on Fri Dec 15 17:17:42 GMT 2023 , Edited by admin on Fri Dec 15 17:17:42 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID5023879
Created by admin on Fri Dec 15 17:17:42 GMT 2023 , Edited by admin on Fri Dec 15 17:17:42 GMT 2023
PRIMARY
CHEBI
30304
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PRIMARY
CHEBI
30513
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PRIMARY
MERCK INDEX
m1953
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PRIMARY Merck Index
DRUG BANK
DB13110
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PRIMARY
MESH
D000965
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PRIMARY
RXCUI
1311407
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PRIMARY RxNorm
PUBCHEM
5354495
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PRIMARY
HSDB
508
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PRIMARY
SMS_ID
100000077405
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PRIMARY
DAILYMED
9IT35J3UV3
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PRIMARY
FDA UNII
9IT35J3UV3
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PRIMARY
NCI_THESAURUS
C95187
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PRIMARY
ECHA (EC/EINECS)
231-146-5
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PRIMARY
EVMPD
SUB12914MIG
Created by admin on Fri Dec 15 17:17:42 GMT 2023 , Edited by admin on Fri Dec 15 17:17:42 GMT 2023
PRIMARY
CAS
7440-36-0
Created by admin on Fri Dec 15 17:17:42 GMT 2023 , Edited by admin on Fri Dec 15 17:17:42 GMT 2023
PRIMARY