Capreomycin is an antibiotic, which is used in combination other antituberculosis drugs fro the treatment of pulmonary infections caused by capreomycin-susceptible strains of M. tuberculosis when the primary agents (isoniazid, rifampin, ethambutol, aminosalicylic acid, and streptomycin) have been ineffective or cannot be used because of toxicity or the presence of resistant tubercle bacilli. Little is known about capreomycin's exact mechanism of action, but it is thought to inhibit protein synthesis by binding to the 70S ribosomal unit. Capreomycin also binds to components in the bacterial cell which result in the production of abnormal proteins.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2363965 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
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| Curative | CAPASTAT SULFATE Approved UseCapastat Sulfate, which is to be used concomitantly with other appropriate antituberculosis agents, is indicated in pulmonary infections caused by capreomycin-susceptible strains of M. tuberculosis when the primary agents (isoniazid, rifampin, ethambutol, aminosalicylic acid, and streptomycin) have been ineffective or cannot be used because of toxicity or the presence of resistant tubercle bacilli. Susceptibility studies should be performed to determine the presence of a capreomycin-susceptible strain of M. tuberculosis. Launch Date1971 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis. | 1998 May |
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| Capreomycin in the treatment of atypical mycobacterial disease in HIV-positive patients. | 2002 Jul |
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| Capreomycin is active against non-replicating M. tuberculosis. | 2005 Apr 1 |
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| Molecular analysis of cross-resistance to capreomycin, kanamycin, amikacin, and viomycin in Mycobacterium tuberculosis. | 2005 Aug |
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| Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs. | 2006 Jul 21 |
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| Capreomycin--a polypeptide antitubercular antibiotic with unusual binding properties toward copper(II). | 2012 Jan |
Sample Use Guides
Intravenously: Capastat Sulfate (Capreomycin for Injection) should be diluted in
100 mL of 0.9% Sodium Chloride Injection and administered over 60 minutes.
Intramuscularly — Reconstituted Capastat Sulfate should be given by deep intramuscular injection into a large muscle mass, since superficial injection may be associated with increased pain and the development of sterile abscesses. For administration of a 1-g dose, the entire contents of the vial should be given. For doses lower than 1 g, the following dilution table may be used.
Route of Administration:
Other
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NCI_THESAURUS |
C2363
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NCI_THESAURUS |
C280
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CHEMBL2221250
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1405-36-3
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C73797
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1091006
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1987
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DBSALT000443
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9H8D3J7V21
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215-776-8
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m3029
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DTXSID30930861
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SUB01029MIG
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755904
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CAPREOMYCIN SULFATE
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PRIMARY | Description: A white or almost white powder. Solubility: Very soluble in water, practically insoluble in ethanol (~750 g/l) TS and in ether. Category: Antituberculosis drug. Storage: Capreomycin sulfate should be kept in a tightly closed container or, if sterile, in a hermetically closed container. Labelling: The label states, where applicable:(1) that the substance is free from bacterial endotoxins,(2) that the substance is sterile. Definition: Capreomycin sulfate is a mixture of the sulfates of antimicrobial polypeptides produced by the growth of Streptomyces capreolus. It contains not less than 70.0% of capreomycin, calculated with reference to the dried substance and taking into account the sum of capreomycin IA, IB, IIA and IIB. The contents of capreomycin IA and IB is not less than 90.0% of the sum of capreomycin IA, IB, IIA and IIB. |
All of the following components must be present:
ACTIVE MOIETY
SUBSTANCE RECORD