AFTOBETIN

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H32N2O5
Molecular Weight	452.5427
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COCCOCCOCCOC(=O)C(=C\C1=CC=C2C=C(C=CC2=C1)N3CCCCC3)\C#N

InChI

InChIKey=NRZNTGUFHSJBTD-HKOYGPOVSA-N

InChI=1S/C26H32N2O5/c1-30-11-12-31-13-14-32-15-16-33-26(29)24(20-27)18-21-5-6-23-19-25(8-7-22(23)17-21)28-9-3-2-4-10-28/h5-8,17-19H,2-4,9-16H2,1H3/b24-18+

HIDE SMILES / InChI

Description
Sources: http://www.cognoptix.com/news/releases/051115.htm | https://www.alumni.ucsd.edu/s/1170/emag/emag-interior-2-col.aspx?sid=1170&gid=1&pgid=3875 | https://ichgcp.net/clinical-trials-registry/NCT02928211 | https://www.ncbi.nlm.nih.gov/pubmed/30151279

Aftobetin, also known as ANCA11 and NCE-11, is a novel amyloid–binding compound applied topically in the form of an ophthalmic ointment. Aftobetin offers a promising way for a noninvasive eye-scan to diagnose Alzheimer’s disease early.

Originator

Approval Year

PubMed

Title	Date	PubMed
Ocular Manifestations of Alzheimer's and Other Neurodegenerative Diseases: The Prospect of the Eye as a Tool for the Early Diagnosis of Alzheimer's Disease.	2018	30151279

Patents

Sample Use Guides

In Vivo Use Guide

Performance of Part I of the study has been completed (15 subjects received a single administration of Aftobetin HCL followed by Sapphire II measurements) and indicated that 3 administrations of Aftobetin-HCl are necessary. For Part II, a second group of up to 30 subjects (CN =10 and mild AD or MCI =20) will receive three Aftobetin HCL administrations.

Route of Administration: Topical

Name

Type

Language

aftobetin [INN]

Preferred Name

English

AFTOBETIN

Official Name

English

COMPOUND 11

Code

English

AFTOBETIN [USAN]

Common Name

English

ANCA-11

Code

English

ANCA11

Code

English

2-[2-(2-Methoxyethoxy)ethoxy]ethyl (2E)-2-cyano-3-[6-(piperidin-1-yl)naphthalen-2-yl]prop-2-enoate

Systematic Name

English

2-PROPENOIC ACID, 2-CYANO-3-(6-(1-PIPERIDINYL)-2-NAPHTHALENYL)-, 2-(2-(2-METHOXYETHOXY)ETHOXY)ETHYL ESTER, (2E)-

Common Name

English

Aftobetin [WHO-DD]

Common Name

English

Code System Code Type Description

INN

9786