TRISILOXANE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H24O2Si3
Molecular Weight	236.5315
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C

InChI

InChIKey=CXQXSVUQTKDNFP-UHFFFAOYSA-N

InChI=1S/C8H24O2Si3/c1-11(2,3)9-13(7,8)10-12(4,5)6/h1-8H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9745729
Curator's Comment: Description was created using several sources including: https://www.tga.gov.au/sites/default/files/consult-otc-argom-sunscreens-100505.pdf; http://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=33742; https://www.ncbi.nlm.nih.gov/pubmed/15379874

Drometrizole trisiloxane is a lipophilic benzotriazole derivative marketed as Mexoryl XL by L'Oréal and is used in sunscreens as a (UV) filtering agent that provide a high sun protection factor (SPF) for daily photoprotection of skin against UV damage and delay the signs of aging. Drometrizole trisiloxane is a broad-spectrum UV absorber with two absorption peaks, one at 303 nm (UVB) and one at 344 nm (UVA). Sunscreens with drometrizole trisiloxane are approved within the EU, Australia and other contries but not in the United States.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Sunburn 84 Sources: http://www.pharmacymix.com/product.aspx?ProductID=4593&deptid=723&	Preventing		Approved 8429	Anthelios XL SPF 60 Melt-In Cream Approved Use Protection against UV and UVB rays.

PubMed

Title	Date	PubMed
"Inert" formulation ingredients with activity: toxicity of trisiloxane surfactant solutions to twospotted spider mites (Acari: Tetranychidae).	2000 Apr	10826161
Nanoscale aggregate structures of trisiloxane surfactants at the solid-liquid interface.	2004 Mar 30	15835139
Allergic contact dermatitis to drometrizole trisiloxane in a sunscreen with concomitant sensitivities to other sun screens.	2005 Apr	15859995

Patents

Sample Use Guides

In Vivo Use Guide

Apply Anthelios XL SPF 60 Melt-In Cream containing 3% drometrizole trisiloxane (Mexoryl XL) to the face and body 15 to 30 minutes before sun exposure. Reapply after swimming or excessive perspiration. Contains drometrizole trisiloxane (Mexoryl XL) 3%

Route of Administration: Topical

In Vitro Use Guide

Unknown

Name

Type

Language

TRISILOXANE

Official Name

English

DIMETHYLBIS(TRIMETHYLSILOXY)SILANE

Systematic Name

English

TRISILOXANE [INCI]

Common Name

English

TRISILOXANE, 1,1,1,3,3,5,5,5-OCTAMETHYL-

Systematic Name

English

FRD 20

Brand Name

English

1,1,1,3,3,5,5,5-OCTAMETHYLTRISILOXANE

Systematic Name

English

XIAMETER(R) PMX-200 SILICONE FLUID 1 CST

Brand Name

English

TRISILOXANE, OCTAMETHYL-

Systematic Name

English

KF 96A1

Code

English

PENTAMETHYL(TRIMETHYLSILYLOXY)DISILOXANE

Systematic Name

English

PENTAMETHYL(TRIMETHYLSILOXY)DISILOXANE

Systematic Name

English

DM-FLUID 1.0CS

Brand Name

English

OS 20 (SILOXANE)

Brand Name

English

VOLASIL DM-1

Brand Name

English

OCTAMETHYLTRISILOXANE [MI]

Common Name

English

OCTAMETHYLTRISILOXANE

Systematic Name

English

Code System Code Type Description

FDA UNII

9G1ZW13R0G