CYCLOBUTYROL SODIUM

Details

Stereochemistry	RACEMIC
Molecular Formula	C10H17O3.Na
Molecular Weight	208.2299
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].CCC(C([O-])=O)C1(O)CCCCC1

InChI

InChIKey=ZIKJCAPMXXTMDD-UHFFFAOYSA-M

InChI=1S/C10H18O3.Na/c1-2-8(9(11)12)10(13)6-4-3-5-7-10;/h8,13H,2-7H2,1H3,(H,11,12);/q;+1/p-1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2574569 | https://www.ncbi.nlm.nih.gov/pubmed/2310370 | https://www.drugfuture.com/chemdata/cyclobutyrol.html

Cyclobutyrol (CB) is a choleretic agent, which also inhibits biliary lipid secretion. Administration of cyclobutyrol reduced biliary concentration and output of cholesterol and phospholipid. This is due to an uncoupling of the secretion of cholesterol and phospholipids from that of bile acids. Biliary outputs of the canalicular membrane enzymes 5'-nucleotidase and alkaline phosphodiesterase I are depressed. The most likely effect of CB is exerted at the level of the canalicular membrane.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
cholesterol efflux 3 Target ID: GO:0033344 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2310370	Inhibitor 8297
phospholipid efflux 3 Target ID: GO:0033700 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2310370	Inhibitor 8297

PubMed

Title	Date	PubMed
Skin sensitizing properties of arylalcanoic acids and their analogues.	1979 Sep	509935

Sample Use Guides

In Vivo Use Guide

Single dose - 0.72 mmol/kg body weight

Route of Administration: Oral

Name

Type

Language

CYCLOBUTYROL SODIUM

Common Name

English

TACHICOL

Brand Name

English

CYCLOBUTYROL SODIUM SALT [MI]

Common Name

English

DIMENE

Brand Name

English

SODIUM .ALPHA.-ETHYL-1-HYDROXYCYCLOHEXANEACETATE

Systematic Name

English

Cyclobutyrol sodium [WHO-DD]

Common Name

English

BILIMIX

Brand Name

English

COLEPAN

Brand Name

English

CYCLOBUTYROL SODIUM [MART.]

Common Name

English

CYCLOBUTYROL SODIUM SALT

Common Name

English

Code System Code Type Description

CAS

1130-23-0