AROTINOLOL HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H21N3O2S3.ClH
Molecular Weight	408.002
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC(C)(C)NCC(O)CSC1=NC(=CS1)C2=CC=C(S2)C(N)=O

InChI

InChIKey=XXDAXBZYUXLDRD-UHFFFAOYSA-N

InChI=1S/C15H21N3O2S3.ClH/c1-15(2,3)17-6-9(19)7-21-14-18-10(8-22-14)11-4-5-12(23-11)13(16)20;/h4-5,8-9,17,19H,6-7H2,1-3H3,(H2,16,20);1H

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11675958
Curator's Comment: description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/6200619

Arotinolol (INN, marketed under the tradename Almarl) is a medication in the class of mixed alpha/beta blockers. It is used in the treatment of high blood pressure and essential tremor. The recommended dosage is 10–30 mg per day.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor beta 87 Target ID: CHEMBL2094118 Sources: http://www.ncbi.nlm.nih.gov/pubmed/6200619	Antagonist 2778
Adrenergic receptor alpha 64 Target ID: CHEMBL2095203 Sources: http://www.ncbi.nlm.nih.gov/pubmed/6200619	Antagonist 2778

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 567 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11675958	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Synthesis and beta-adrenergic blocking action of a new thiazolylthiopropanolamine derivative.	1978 Sep	29117
Clinical trial of arotinolol in the treatment of hypertension: dippers vs. non-dippers.	2001 Sep	11675958
Micellar electrokinetic capillary chromatography determination of +S and -R arotinolol in serum using UV detection and solid phase extraction.	2002 Jan	11748803
Relapse of Graves' disease in a patient with pheochromocytoma.	2003 Dec	14709850
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010 Dec	21818443

Patents

Sample Use Guides

In Vivo Use Guide

10-20 mg twice daily for 4 weeks

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

AROTINOLOL HYDROCHLORIDE

Common Name

English

AROTINOLOL HYDROCHLORIDE [MART.]

Common Name

English

Arotinolol hydrochloride [WHO-DD]

Common Name

English

AROTINOLOL HCL

Common Name

English

AROTINOLOL HYDROCHLORIDE [JAN]

Common Name

English

2-THIOPHENECARBOXAMIDE, 5-(2-((3-((1,1-DIMETHYLETHYL)AMINO)-2-HYDROXYPROPYL)THIO)-4-THIAZOLYL)-, MONOHYDROCHLORIDE, (±)-

Common Name

English

(±)-2-(3'-TERT-BUTYLAMINO-2'-HYDROXYPROPYLTHIO)-4-(5'-CARBAMOYL-2'-THIENYL)THIAZOLE HCL

Common Name

English

AROTINOLOL HYDROCHLORIDE [MI]

Common Name

English

Code System Code Type Description

MERCK INDEX

m2052