AROTINOLOL HYDROCHLORIDE

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H21N3O2S3.ClH
Molecular Weight	408.002
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

Cl.CC(C)(C)NCC(O)CSC1=NC(=CS1)C2=CC=C(S2)C(N)=O

InChI

InChIKey=XXDAXBZYUXLDRD-UHFFFAOYSA-N

InChI=1S/C15H21N3O2S3.ClH/c1-15(2,3)17-6-9(19)7-21-14-18-10(8-22-14)11-4-5-12(23-11)13(16)20;/h4-5,8-9,17,19H,6-7H2,1-3H3,(H2,16,20);1H

HIDE SMILES / InChI

Description

Arotinolol (INN, marketed under the tradename Almarl) is a medication in the class of mixed alpha/beta blockers. It is used in the treatment of high blood pressure and essential tremor. The recommended dosage is 10–30 mg per day.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Adrenergic receptor beta 89	Antagonist 2,849
Adrenergic receptor alpha 65	Antagonist 2,849

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hypertension 575	Primary		Preclinical	Unknown

PubMed

Show entries

Title	Date	PubMed
Synthesis and beta-adrenergic blocking action of a new thiazolylthiopropanolamine derivative.	1978 Sep	29117
Enantioselective determination of arotinolol in human plasma by HPLC using teicoplanin chiral stationary phase.	2003 Oct	14598329
Effects of a pure alpha/beta-adrenergic receptor blocker on monocrotaline-induced pulmonary arterial hypertension with right ventricular hypertrophy in rats.	2009 Dec	19822980
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010 Dec	21818443

Showing 1 to 4 of 4 entries

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Patents

Sample Use Guides

In Vivo Use Guide

10-20 mg twice daily for 4 weeks

Route of Administration: Oral

In Vitro Use Guide

Unknown

Show entries

Name

Type

Language

(±)-2-(3'-TERT-BUTYLAMINO-2'-HYDROXYPROPYLTHIO)-4-(5'-CARBAMOYL-2'-THIENYL)THIAZOLE HCL

Preferred Name

English

AROTINOLOL HYDROCHLORIDE

Common Name

English

AROTINOLOL HYDROCHLORIDE [MART.]

Common Name

English

Arotinolol hydrochloride [WHO-DD]

Common Name

English

AROTINOLOL HCL

Common Name

English

Showing 1 to 5 of 8 entries

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Show entries

Code System

Code

Type

Description

MERCK INDEX

m2052

PRIMARY

Merck Index

PUBCHEM

155032

PRIMARY

EPA CompTox

DTXSID1046849

PRIMARY

MESH

C024523

PRIMARY

SMS_ID

100000085340

PRIMARY

Showing 1 to 5 of 9 entries

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ACTIVE MOIETY


					394E3P3B99

AROTINOLOL

SUBSTANCE RECORD


					9DOI1HT306

AROTINOLOL HYDROCHLORIDE