U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula Mg.3O.Si
Molecular Weight 100.3887
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MAGNESIUM SILICATE

SMILES

[O--].[O--].[O--].[Mg++].[Si+4]

InChI

InChIKey=ZADYMNAVLSWLEQ-UHFFFAOYSA-N
InChI=1S/Mg.3O.Si/q+2;3*-2;+4

HIDE SMILES / InChI
Talcum powder is made from talc, a mineral made up mainly of the elements magnesium, silicon, and oxygen. As a powder, it absorbs moisture well and helps cut down on friction, making it useful for keeping skin dry and helping to prevent rashes. It is widely used in cosmetic products such as baby powder and adult body and facial powders, as well as in a number of other consumer products. The therapeutic action of talc instilled into the pleural cavity is believed to result from induction of an inflammatory reaction. This reaction promotes adherence of the visceral and parietal pleura, obliterating the pleural space and preventing reaccumulation of pleural fluid. Sterile Talc Powder, administered intrapleurally via chest tube, is indicated as a sclerosing agent to decrease the recurrence of malignant pleural effusions in symptomatic patients. The most often reported adverse experiences to intrapleurally-administered talc were fever and pain.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Preventing
SCLEROSOL

Approved Use

Sclerosol® Intrapleural Aerosol, administered by aerosol during thoracoscopy or open thoracotomy, is indicated to prevent recurrence of malignant pleural effusions in symptomatic patients.

Launch Date

1997

Sample Use Guides

The recommended dose is 5 g, suspended in 50 ml to 100 ml 0.9% Sodium Chloride Injection, USP
Route of Administration: Intrapleural
Name Type Language
MAGNESIUM SILICATE
FCC   HSDB   II   INCI   MART.   WHO-DD  
INCI  
Official Name English
E-553(I)
Code English
MAGNESIUM HYDROSILICATE
Common Name English
SILICIC ACID, MAGNESIUM SALT
Common Name English
MAGNESIUM SILICATE, SYNTHETIC
Common Name English
MAGNESIUM SILICATE [HSDB]
Common Name English
MAGNESIUM SILICATE [FCC]
Common Name English
MAGNESIUM SILICATE [II]
Common Name English
MAGNESIUM SILICATE (TALC)
Common Name English
MAGNESIUM SILICATE [MART.]
Common Name English
Magnesium silicate [WHO-DD]
Common Name English
INS-553(I)
Code English
MAGNESIUM SILICATE [INCI]
Common Name English
INS NO.553(I)
Code English
Classification Tree Code System Code
EPA PESTICIDE CODE 72601
Created by admin on Fri Dec 15 16:56:42 GMT 2023 , Edited by admin on Fri Dec 15 16:56:42 GMT 2023
WHO-VATC QA02AA05
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JECFA EVALUATION INS-553(I)
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CFR 21 CFR 582.2437
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DSLD 2292 (Number of products:3)
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WHO-ATC A02AA05
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CFR 21 CFR 176.170
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CFR 21 CFR 178.3297
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CODEX ALIMENTARIUS (GSFA) INS-553(I)
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Code System Code Type Description
DRUG BANK
DB13249
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PRIMARY
DRUG CENTRAL
4513
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PRIMARY
FDA UNII
9B9691B2N9
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PRIMARY
DAILYMED
9B9691B2N9
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PRIMARY
PUBCHEM
72941442
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PRIMARY
CAS
1343-88-0
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PRIMARY
ChEMBL
CHEMBL2109133
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PRIMARY
RXCUI
1310566
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PRIMARY RxNorm
HSDB
5823
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PRIMARY
ECHA (EC/EINECS)
215-681-1
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PRIMARY
EVMPD
SUB14446MIG
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PRIMARY
SMS_ID
100000076810
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PRIMARY