ACID GREEN 50

Details

Stereochemistry	ACHIRAL
Molecular Formula	C27H25N2O7S2.Na
Molecular Weight	576.616
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].CN(C)C1=CC=C(C=C1)C(=C2C=CC(C=C2)=[N+](C)C)C3=C4C=CC(=CC4=CC(=C3O)S([O-])(=O)=O)S([O-])(=O)=O

InChI

InChIKey=WDPIZEKLJKBSOZ-UHFFFAOYSA-M

InChI=1S/C27H26N2O7S2.Na/c1-28(2)20-9-5-17(6-10-20)25(18-7-11-21(12-8-18)29(3)4)26-23-14-13-22(37(31,32)33)15-19(23)16-24(27(26)30)38(34,35)36;/h5-16H,1-4H3,(H2,31,32,33,34,35,36);/q;+1/p-1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21836630 | https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=16a8622b-b349-4b10-b45a-f1f1551b2b06

Acid green 50 (Lissamine Green B) is a synthetically produced organic acid dye with two aminophenyl groups. Acid green 50 is extensively used as a food dye and has a medical application as a staining agent. Due to its low toxicity and ability to stain dead and damaged cells the dye (in form of lissamine green strips) was approved as a tool for diagnosis of eye diseases associated with the damage of ocular surface epithelial cells.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dead or degenerated cells 2 Target ID: Dead or degenerated cells Sources: https://www.ncbi.nlm.nih.gov/pubmed/7510270	Interacts 323

Conditions

Condition	Modality	Targets	Highest Phase	Product
Eye diseases 26 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=16a8622b-b349-4b10-b45a-f1f1551b2b06	Diagnostic		Approved 8583	LISSAMINE GREEN Approved Use For use as a diagnostic agent when superficial corneal or conjunctival tissue change is suspected.

PubMed

Title	Date	PubMed
Long-term outcome after topical ciclosporin in severe dry eye disease with a 10-year follow-up.	2016-11	26823393
Symptoms of Dry Eye Disease and Personality Traits.	2016	27861642
Optimizing evaluation of Lissamine Green parameters for ocular surface staining.	2011-11	21836630
Micro-determination of inulin concentration in a solution containing lissamine green.	1970-09	5312657
Lissamine green--a supravital stain for determination of corneal endothelial viability.	1967-10	4168462
Factors affecting the uptake of lissamine green by serum proteins.	1960-03	13803681

Patents

Sample Use Guides

In Vivo Use Guide

For best viewing and patient comfort, acid green 50 (Lissamine Green) impregnated tip should be moistened with one or two drops of sterile irrigating or saline solution before application. Apply moistened tip to conjunctiva or fornix as required. It is recommended that the patient blink several times after application.

Route of Administration: Other

In Vitro Use Guide

Human corneal epithelial (HCE) cells were exposed to 1, 0.5, or 0.1% of acid green 50 (lissamine green) and the cells viability was studied. No observable staining of healthy HCE cells was noted with acid green 50.

Name

Type

Language

CI 44090

Preferred Name

English

ACID GREEN 50

Official Name

English

GREEN S (E 142)

Common Name

English

METHANAMINIUM, N-(4-((4-(DIMETHYLAMINO)PHENYL)(2-HYDROXY-3,6-DISULFO-1-NAPHTHALENYL)METHYLENE)-2,5-CYCLOHEXADIEN-1-YLIDENE)-N-METHYL-, INNER SALT, SODIUM SALT (1:1)

Common Name

English

GREEN S

Common Name

English

C.I. ACID GREEN 50

Common Name

English

FOOD GREEN S

Common Name

English

NSC-11237

Code

English

LISSAMINE GREEN BN

Common Name

English

GREEN S [MI]

Common Name

English

ACID GREEN BS

Common Name

English

ACID GREEN RS

Common Name

English

C.I. 44090

Common Name

English

NSC-71959

Code

English

Code System Code Type Description

DAILYMED

9B7E8Y9D0X